Abstract
Multicellular organisms must evolve mechanisms to suppress cancer formation prior to reproduction, and we propose that the organizational structure of normal epithelium is one such strategy. Understanding evolved host cancer suppression mechanisms is essential to defining the first steps of carcinogenesis and developing rational cancer prevention strategies.
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Acknowledgements
This work was funded by the Moffitt Cancer Center Physical Sciences-Oncology Center NIH/NCI 1U54CA143970-01.
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Gatenby, R., Gillies, R. & Brown, J. The evolutionary dynamics of cancer prevention. Nat Rev Cancer 10, 526–527 (2010). https://doi.org/10.1038/nrc2892
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DOI: https://doi.org/10.1038/nrc2892
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