Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Ablation of cancer stem cells in established glioblastomas in mice by knockout of the nuclear receptor tailless (Tlx) has therapeutic benefit, and TLX may have a similar role in human glioblastoma stem cells.
Two papers inCancer Cellreport the surprising findings that some components of the pancreatic cancer microenvironment suppress, rather than promote, tumour progression.
The poly(ADP-ribose) polymerase (PARP) family comprises 17 enzymes, which generate poly(ADP-ribose) and/or mono(ADP-ribose) (MAR) that can modify target protein function and can function as a signalling scaffold. These modifications may have various roles in cancer and, as discussed in this Opinion article, inhibitors of MARylation in particular may warrant investigation as anticancer drugs.
Adleret al. identify PRPF6as an important driver of colon cancer cell growth and suggest it promotes proliferation by preferential splicing of growth-promoting genes.
Cell competition occurs in the thymus to promote natural turnover of older progenitor cells, and mice lacking such competition develop T cell acute lymphoblastic leukaemia (T-ALL).
The cohesin complex is involved in sister chromatid cohesion, as well as other processes, such as transcriptional regulation. Mutations in genes encoding cohesin subunits and cohesin regulators have recently been identified in several tumour types. This Progress article discusses the roles of the cohesin complex and how its mutation might contribute to cancer progression.
There is a clinical need for biomarkers to identify women with progressive cervical intraepithelial neoplasia (CIN) lesions to tailor clinical management and prevent overtreatment. This Review discusses the advances in understanding genetic and epigenetic alterations that underlie cervical cancer development, which offer opportunities for the molecular distinction of cervical cancer precursor lesions.
This Review highlights how intravital microscopy techniques have been used in living animals (predominantly mice) to unravel fundamental and dynamic aspects of several processes that are crucial for the initiation and progression of tumours, and it discusses future perspectives for these techniques.
This paper indicates that a global loss of microRNAs reduces the growth of non-small-cell lung cancer cellsin vivoowing to the suppression of tumour angiogenesis.
