Somatic mutations in mediator complex subunit 12 (MED12) occur in approximately 70% of uterine leiomyomas. Turunen, Spaeth et al. showed that the MED12 mutations disrupted the binding of MED12 with cyclin C, which is required for the stimulation of cyclin C–cyclin-dependent kinase 8 (CDK8) activity. This resulted in a loss of CDK activity that is associated with the mediator complex.
References
Turunen, M. et al. Uterine leiomyoma-linkedMED12 mutations disrupt mediator-associated CDK activity. Cell Rep. 7, 654–660 (2014)
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Alderton, G. Mediating tumorigenesis. Nat Rev Cancer 14, 382 (2014). https://doi.org/10.1038/nrc3757
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DOI: https://doi.org/10.1038/nrc3757
