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Patricia L. M. Dahia gives an overview of insights learned from the study of pheochromocytomas and paragangliomas, which carry the highest degree of heritability of all human tumours.
The cadherin superfamily includes many proteins other than E-cadherin. These cadherins are very diverse in both structure and function, and their mutual interactions seem to influence cancer development and progression in complex and versatile ways.
Inhibitor of DNA binding (ID) proteins are transcriptional regulators that control the timing of cell fate determination and differentiation in stem and progenitor cells. The ability of ID proteins to function as central 'hubs' for the coordination of multiple cancer hallmarks is establishing them as therapeutic targets and biomarkers in specific types of human tumours.
Stage MS neuroblastoma is unique in that it regresses without treatment. Could a better understanding of the biology of these tumours inform how high-risk neuroblastoma and other paediatric malignancies are treated?