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    These Milestones celebrate two decades of breakthroughs in basic, translational and clinical research which have revolutionized our understanding and management of cancer.

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    Nature Reviews Cancer is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is recognised. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process.

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    The Nature Reviews journals present this regularly updated Collection on women's health, with articles featuring in-depth content on the biology & health conditions that affect people with female-specific organs and hormonal cycles.

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  • In this Journal Club, Hassan Brim and Hassan Ashktorab discuss a publication that reported the involvement of the microbiome in colorectal cancer metastasis.

    • Hassan Brim
    • Hassan Ashktorab
    Journal Club
  • Two studies published in Nature Cancer and Nature Communications describe the discovery of first-in-class, potent and specific inhibitors of Polϴ to target homologous recombination-deficient cancers.

    • Anna Dart
    Research Highlight
  • Casanova-Acebes et al. show that tissue-resident macrophages provide a unique niche for tumour cells in the lung to promote invasiveness and regulatory T cell-mediated immune suppression.

    • Ulrike Harjes
    Research Highlight
  • Martirosian et al. show that a metabolic mechanism used by neurons and astrocytes during periods of nutrient deprivation and stress may have a role in leptomeningeal dissemination of medulloblastoma.

    • Sarah Seton-Rogers
    In Brief
  • Andrews et al. provide evidence that immune-related adverse events following cancer immunotherapy may be linked to the patient’s gut microbiota.

    • Sarah Seton-Rogers
    In Brief
  • Torrino et al. report that extracellular matrix stiffening stabilizes microtubules by glutaminolysis-dependent microtubule glutamylation, thereby promoting breast cancer progression.

    • Ulrike Harjes
    Research Highlight
Diet and systemic metabolism

Diet and systemic metabolism

This series of articles explores how changes in diet and systemic metabolism can influence tumour development and progression, how this is affected by the presence of metabolic disease and how we can use this knowledge to improve anticancer therapy.
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