Glial and myeloid heterogeneity in the brain tumour microenvironment

Brian M. Andersen, Camilo Faust Akl, Michael A. Wheeler, E. Antonio Chiocca, David A. Reardon & Francisco J. Quintana

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  • Kaushik Tiwari et al. have developed a strategy to directly target amplified genes in cancer using triplex-forming oligonucleotides, which selectively induce DNA damage and apoptosis in cancer cells with copy number gains.

    • Anna Dart
    In Brief
  • Guo et al. have developed a novel strategy, which involves coating tumour cells with silica, to enable personalized cancer vaccines to overcome the immunosuppressive effects of the tumour microenvironment.

    • Anna Dart
    In Brief
  • Klemm et al. examined the role of tumour-associated macrophages (TAMs) at different stages of brain metastasis in mouse models and found that targeting TAMs by inhibiting both CSF1R and STAT5 might have long-lasting efficacy and prevent resistance.

    • Sarah Seton-Rogers
    Research Highlight
  • Pernigoni et al. present a unique mode of non-genetic resistance accounting for castration-resistant prostate cancer that is mediated by androgen-synthesizing gut microbiota.

    • Anna Dart
    Research Highlight
  • Neuhöfer et al. have identified a rare subpopulation of pancreatic acinar cells in the exocrine compartment that renews the pancreas by fuelling clonal expansion. When harbouring Kras mutations, these acinar cells accelerated clone formation and might represent an early cancer precursor lesion.

    • Linda Gummlich
    Research Highlight
Diet and systemic metabolism

Diet and systemic metabolism

This series of articles explores how changes in diet and systemic metabolism can influence tumour development and progression, how this is affected by the presence of metabolic disease and how we can use this knowledge to improve anticancer therapy.
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