The Greek god Hermes

The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment

Margarita Bartish, Madelyn J. Abraham, Christophe Goncalves, Ola Larsson, Charlotte Rolny & Sonia V. del Rincon  


  • birthday balloons that look like cancer cells making the number 20

    October 2021 marked the 20th anniversary of Nature Reviews Cancer. This Collection includes cutting-edge articles, including our anniversary issue contents, and thought-provoking commentaries and viewpoints. We also delve into our archives as a reminder of where the journal started and all that has been achieved in cancer research since the journal’s launch.

  • two people representing an early-career researcher and their mentor

    Nature Reviews Cancer is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is recognised. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process.

  • "crab" symbol formed from individual cancer cells

    These Milestones celebrate two decades of breakthroughs in basic, translational and clinical research which have revolutionized our understanding and management of cancer.

  • Trees made out of cells

    THE TUMOUR LANDSCAPE: TRANSLATING MECHANISM TO THERAPY. Join Nature Reviews Cancer, alongside Nature and Nature Cancer in New York for our 3rd Nature Conference with MSKCC. This meeting will focus on how to translate recent technological, biological, translational and clinical advances of the tumour ecosystem to the clinic. October 29th, 2023 – November 1st, 2023. Register now!


    • In this Perspective article, Mel Greaves and co-workers outline emerging evidence that suggests that children with newly diagnosed acute lymphoblastic leukaemia may have a delayed maturation of the gut microbiome compared with healthy children, a deficit that might be associated with early-life epidemiological factors and could contribute to the risk of transformation of preleukaemic clones in response to common infectious triggers.

      • Ioannis Peppas
      • Anthony M. Ford
      • Mel F. Greaves
    • In this Perspective, the authors suggest that different tumour microenvironments have ‘archetypal’ qualities across all cancers — characteristic and repeating collections of cells and gene-expression profiles at the level of the bulk tumour. They propose the existence of 12 dominant immune archetypes.

      • Alexis J. Combes
      • Bushra Samad
      • Matthew F. Krummel
    • In this Review, Schwenck et al. discuss how PET imaging of cancer has advanced through its combination with CT and MRI and the development of an array of imaging probes, and how these innovations now need to be fully integrated into the clinic to improve cancer diagnostics and guide therapy.

      • Johannes Schwenck
      • Dominik Sonanini
      • Bernd J. Pichler
      Review Article
    • In this Review, Banushi et al. discuss how endocytotic pathways impact many cancer processes including nutrient scavenging, metastasis and therapeutic drug delivery, and how knowledge of these pathways can be used to improve cancer therapy in the clinic.

      • Blerida Banushi
      • Shannon R. Joseph
      • Fiona Simpson
      Review Article
    • Eukaryotic initiation factor 4F (eIF4F) controls the translation of a subset of transcripts that include those encoding oncogenic proteins. In this Perspective article, Bartish et al. discuss the implications of targeting eIF4F on immune and stromal cells in the tumour microenvironment. In addition to discussing data from cancer models, the authors incorporate extensive data from non-cancer contexts to identify potential desirable or unwanted effects of eIF4F inhibition in these cells.

      • Margarita Bartish
      • Madelyn J. Abraham
      • Sonia V. del Rincón
  • In this Tool of the Trade article, Eva Freckmann describes the development of Traject3d, a workflow that enables the detection of heterogeneous phenotypes in 3D culture by analysing label-free multi-day time-lapse imaging.

    • Eva C. Freckmann
    Tools of the Trade
  • In this study, Insco et al. find patient-specific CDK13 mutations to impede RNA surveillance, leading to the accumulation and translation of prematurely terminated RNAs that drive malignancy in melanoma models.

    • Gabrielle Brewer
    Research Highlight
  • Sloan and colleagues demonstrate that anthracycline chemotherapy drives metastatic progression by stimulating a cancer cell-mediated increase in nerve fibre activity in the tumour microenvironment, which can be reversed by the use of β-blockers.

    • Daniela Senft
    Research Highlight
  • In a recent study on castration-resistant prostate cancer, Cui et al. uncover a role for cancer-associated fibroblasts (CAFs) in inducing androgen synthesis in prostate cancer cells.

    • Gabrielle Brewer
    Research Highlight
A triangle showing a human body in one corner, foods in one corner and cancer cells in the third corner, all connected by arrows as a cycle

Diet and systemic metabolism

This series of articles explores how changes in diet and systemic metabolism can influence tumour development and progression, how this is affected by the presence of metabolic disease and how we can use this knowledge to improve anticancer therapy.


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