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This Perspective discusses the use of CRISPR–Cas9-mediated gene conversion systems in laboratory and wild rodents. Although technical hurdles must be overcome before wild-release strategies are feasible, modest improvements could increase the efficiency and reduce the cost of mouse genetics in the laboratory.
This Perspective from the Harvard Chan Microbiome in Public Health Center describes a generalizable and scalable approach to stool and oral microbiome and metadata collection in the Micro-N (Microbiome Among Nurses) study, to show how to carry out prospective studies of the microbiome.