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Volume 15 Issue 10, October 2020

Fibres formed from bimolecular condensates

It is increasingly apparent that a wide range of proteins present as functional condensates in living cells can undergo a liquid-to-solid transition to form pathological solid protein aggregates associated with disease. Yet, whether such condensates can undergo a liquid-to-solid transition in vitro driven by physical factors remains unexplored. Y. Shen, T. Knowles and co-workers report a general shear response of peptides and proteins that can form solid fibres from liquid–liquid phase separated condensates. During this process, shear forces favour molecular alignment, promote inter-molecular interactions and trigger a liquid-to-solid transition driven by hydrogen bonding. The cover image shows an artistic impression of fibre formation from a condensate.

See Shen et al.

Image: Ella Maru Studio. Cover Design: Bethany Vukomanovic.

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