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It is increasingly apparent that a wide range of proteins present as functional condensates in living cells can undergo a liquid-to-solid transition to form pathological solid protein aggregates associated with disease. Yet, whether such condensates can undergo a liquid-to-solid transition in vitro driven by physical factors remains unexplored. Y. Shen, T. Knowles and co-workers report a general shear response of peptides and proteins that can form solid fibres from liquid–liquid phase separated condensates. During this process, shear forces favour molecular alignment, promote inter-molecular interactions and trigger a liquid-to-solid transition driven by hydrogen bonding. The cover image shows an artistic impression of fibre formation from a condensate.
After fourteen years of writing for Nature Nanotechnology, Chris Toumey reflects on the role of experts in Science and Technology Studies in his last contribution to the journal.
Co-drawing of metallic glass with polymers of similar viscosity–temperature behaviour enables highly uniform nanoscale cross-sectional features of various shapes in functional fibres without length limit.
In situ NMR and magnetic resonance imaging unravel new chemistries for the formation and growth of metal microstructures, with consequences on the solid–electrolyte interphase stability.
This Review proposes a framework for designing delivery systems to target diseased tissues based on the biology of the target, the journey and computational algorithms.
The quantum anomalous Hall state is characterized by a dissipationless chiral edge current. When slightly carrier-doped, Cr-doped (Bi,Sb)2Te3, a magnetic topological insulator, shows current-direction-dependent resistance with a directional difference up to 26%, which probably originates from scattering between the chiral edge state and the Dirac surface state.
Measurements of electrical conductance in double-stranded DNA suggest that the backbones mediate the long-distance conduction in dsDNA, contrary to the common wisdom in DNA electronics.
Spillover hydrogenation is facet specific and occurs on atomically dispersed Pd catalyst on Cu(100). Knowing this, cost-effective catalysts with extremely low Pd loading are fabricated that successfully catalyse the semi-hydrogenation of a broad range of alkynes with high activity and selectivity.
A combination of room-temperature nano-optical imaging and spectroscopy and atomistic theory reveals highly localized exciton states in nanobubbles of localized strain in monolayer WSe2.
Well-controlled multilayer graphene up to four layers thick with a defined stacking sequence is synthesized via SiC alloy formation on a Cu(111) substrate.
Metallic glasses possess intriguing functional properties, but controlled fabrication with nanoscale feature sizes remains challenging. Thermal co-drawing within a viscosity-matched polymer matrix enables the fabrication of uniform metallic glass fibres with feature sizes down to a few tens of nanometres, arbitrary transverse geometries and aspect ratios greater than 1010.