Volume 14 Issue 12, December 2019

The regulatory approval of Onpattro, a lipid nanoparticle-based short interfering RNA drug for the treatment of polyneuropathies induced by hereditary transthyretin amyloidosis, paves the way for clinical development of many nucleic acid-based therapies enabled by nanoparticle delivery.

The magnetic phase diagram of thin-layered antiferromagnets is revealed experimentally by investigating the tunnelling conductance as a function of magnetic field. A rich magnetic behaviour in CrCl₃ is uncovered, from which relevant magnetic information is extracted that is not easily available with other approaches.

Composite electrodes made of nanowires and bovine serum albumin enable electrochemical protein biosensors that can be used in whole blood for a month or more.

The self-propulsion direction of enzyme-loaded liposomes is controlled by the activity of the ions in solution.

This review highlights key opportunistic areas for applying nanotechnologies towards the manipulation of the microbiome for the treatment of cancer, gives an overview of seminal work and discusses future challenges and our perspective on this emerging area.

Engineering the interlayer coupling in a van der Waals heterostructure enables electrical control over the transport and density of valley-polarized interlayer excitons.

Coupling the emission of upconversion nanoparticles to gap plasmon modes enables a direct observation of upconversion superburst with directional, fast and ultrabright luminescence.

A comprehensive understanding of the magnetic phase diagram of atomically thin layered antiferromagnets is obtained by combining systematic tunnelling magnetoconductance measurements with theoretical modelling.

Transition metal dichalcogenide monolayers can host Ising-type superconductivity and if two such layers are coupled, exotic superconducting phases may emerge. Here, the authors induce a coupled superconducting state with tuneable Ising protection by means of symmetric, double-side ionic liquid gating.

Enzyme-coated liposomal motors show either positive or negative chemotaxis depending on the interplay between enzyme catalysis and solute–phospholipid interactions.

Site-selective chemistry is performed on a polymer confined and extended in a nanotube by controlling the spatial alignment of the reactive groups.

An antifouling coating for electrodes that consists of a three-dimensional porous matrix of cross-linked bovine serum albumin supported by a network of conductive nanomaterials enables robust affinity-based electrochemical biosensing in complex biological fluids.

A pH-responsive, soft polymeric nanoparticle targets the neurokinin 1 receptor in acidified endosomes to inhibit signalling events leading to chronic pain.

Nitric oxide delivered and released by a nanoscale carrier improves the therapeutic effectiveness of chemotherapeutics and immunotherapy by normalizing tumour vasculature.