Volume 13 Issue 1, January 2018

Volume 13 Issue 1

How to resist silver

The resistance of bacteria against antibiotics represents one of the biggest issues of the 21st century. Nanotechnologies applying silver nanoparticles are considered an emerging tool in antimicrobial therapies as their action has not yet been associated with any resistance. A. Panáček, L. Kvítek, R. Zbořil and co-workers have now discovered that gram-negative bacteria repeatedly exposed to silver nanoparticles can develop resistance to their antibiotic activity. The cover is an artist’s rendition of the resistance mechanism based on the production of flagellin — an adhesive protein of bacterial flagellum, which causes nanoparticles’ aggregation and thereby eliminates their antibacterial effect. Importantly, the resistance evolves without any genetic changes and can be overcome by the addition of pomegranate rind extract inhibiting the flagellin production in bacteria.

See Panáček et al.

Image: Martin Pykal, Aleš Panáček, Libor Kvítek, and Radek Zbořil, Palacky Universitý Olomouc, Czech Republic. Cover Design: Alex Wing

Editorial

  • Editorial |

    We introduce an advisory panel to develop content on the relationship between technology and society.

  • Editorial |

    Scalability and cost efficiency should intensify research efforts in DNA nanotechnology.

Thesis

  • Thesis |

    Chris Toumey revisits the 2003 exchange of opinions between Eric Drexler and Richard Smalley, which was one of the most colourful disagreements in the history of nanotechnology.

    • Chris Toumey

Research Highlights

News & Views

  • News & Views |

    The microstate of geometrically frustrated two-dimensional arrays of strongly interacting nanomagnets is controlled by means of topological defect-driven magnetic writing, to the extent that elusive configurations such as the ground state and negative-temperature states are realized.

    • Cristiano Nisoli
  • News & Views |

    Nanoparticles loaded with paclitaxel and nintedanib induce synthetic lethality in endometrial cancer cells.

    • Christian Rolfo
    •  & Elisa Giovannetti
  • News & Views |

    Negative capacitance effect in a ferroelectric-based gate stack provides an effective solution for hysteresis-free steep-slope  operation in a MoS2 field-effect transistor.

    • Adrian M. Ionescu
  • News & Views |

    A terbium-based molecular magnet, containing four nuclear quantum states, or a qudit, experimentally validates the Grover algorithm for database searches.

    • Andrea Morello

Perspectives

  • Perspective |

    This Perspective describes the fundamental principles of nano-opto-electo-mechanical systems and their applications in communication, sensing and signal transduction.

    • Leonardo Midolo
    • , Albert Schliesser
    •  & Andrea Fiore

Letters

  • Letter |

    Electric polarization is induced in the binary rock salt layer of an ultrathin insulating heterostructure on a metal electrode, and its hysteretic reversal is demonstrated using a combination of atomically resolved scanning probe microscopies.

    • Jose Martinez-Castro
    • , Marten Piantek
    • , Sonja Schubert
    • , Mats Persson
    • , David Serrate
    •  & Cyrus F. Hirjibehedin
  • Letter |

    A field-effect MoS<Subscript>2</Subscript> transistor with a negative capacitor in its gate shows stable, hysteresis-free performance characterized by a sub-thermionic sub-threshold slope.

    • Mengwei Si
    • , Chun-Jung Su
    • , Chunsheng Jiang
    • , Nathan J. Conrad
    • , Hong Zhou
    • , Kerry D. Maize
    • , Gang Qiu
    • , Chien-Ting Wu
    • , Ali Shakouri
    • , Muhammad A. Alam
    •  & Peide D. Ye
  • Letter |

    A hybrid molecular motor made of an engineered protein and an RNA lever arm shows bidirectional transport controlled by oligonucleotide signals.

    • Tosan Omabegho
    • , Pinar S. Gurel
    • , Clarence Y. Cheng
    • , Laura Y. Kim
    • , Paul V. Ruijgrok
    • , Rhiju Das
    • , Gregory M. Alushin
    •  & Zev Bryant
  • Letter |

    Observation of an efficient out-of-plane energy transfer channel in van der Waals heterostructures, where charge carriers in graphene couple to hyperbolic phonon&#x02013;polaritons on a picosecond timescale.

    • Klaas-Jan Tielrooij
    • , Niels C. H. Hesp
    • , Alessandro Principi
    • , Mark B. Lundeberg
    • , Eva A. A. Pogna
    • , Luca Banszerus
    • , Zoltán Mics
    • , Mathieu Massicotte
    • , Peter Schmidt
    • , Diana Davydovskaya
    • , David G. Purdie
    • , Ilya Goykhman
    • , Giancarlo Soavi
    • , Antonio Lombardo
    • , Kenji Watanabe
    • , Takashi Taniguchi
    • , Mischa Bonn
    • , Dmitry Turchinovich
    • , Christoph Stampfer
    • , Andrea C. Ferrari
    • , Giulio Cerullo
    • , Marco Polini
    •  & Frank H. L. Koppens

Articles

  • Article |

    Boron-nitride-supported graphene transistors show prominent current and noise temperature saturation due to hyperbolic phonon emission by non-equilibrium electron–hole pairs.

    • Wei Yang
    • , Simon Berthou
    • , Xiaobo Lu
    • , Quentin Wilmart
    • , Anne Denis
    • , Michael Rosticher
    • , Takashi Taniguchi
    • , Kenji Watanabe
    • , Gwendal Fève
    • , Jean-Marc Berroir
    • , Guangyu Zhang
    • , Christophe Voisin
    • , Emmanuel Baudin
    •  & Bernard Plaçais
  • Article |

    Gram-negative bacteria exposed to subinhibitory concentrations of silver nanoparticles can develop resistance to their antibiotic activity due to the production of flagellin, an adhesive protein of the bacterial flagellum, which causes the aggregation of silver nanoparticles.

    • Aleš Panáček
    • , Libor Kvítek
    • , Monika Smékalová
    • , Renata Večeřová
    • , Milan Kolář
    • , Magdalena Röderová
    • , Filip Dyčka
    • , Marek Šebela
    • , Robert Prucek
    • , Ondřej Tomanec
    •  & Radek Zbořil
  • Article |

    The combination of paclitaxel and the antiangiogenic agent BIBF 1120, loaded into nanoparticles, induces synthetic lethality in endometrial cancers with specific mutations in the tumour suppressor p53, providing the first step towards personalized medicine for endometrial cancer.

    • Kareem Ebeid
    • , Xiangbing Meng
    • , Kristina W. Thiel
    • , Anh-Vu Do
    • , Sean M. Geary
    • , Angie S. Morris
    • , Erica L. Pham
    • , Amaraporn Wongrakpanich
    • , Yashpal S. Chhonker
    • , Daryl J. Murry
    • , Kimberly K. Leslie
    •  & Aliasger K. Salem
  • Article |

    RNA nanotechnology is utilized for directional control by altering the orientation of arrow-shaped RNAs for either ligand-display on extracellular vesicle or to regulate intracellular trafficking of siRNA or miRNA in cancer treatment.

    • Fengmei Pi
    • , Daniel W. Binzel
    • , Tae Jin Lee
    • , Zhefeng Li
    • , Meiyan Sun
    • , Piotr Rychahou
    • , Hui Li
    • , Farzin Haque
    • , Shaoying Wang
    • , Carlo M. Croce
    • , Bin Guo
    • , B. Mark Evers
    •  & Peixuan Guo

In the Classroom

  • In the Classroom |

    Failure is an unavoidable element of the process that leads to discovery and it should be embraced even in early education, says Deji Akinwande.

    • Deji Akinwande