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Volume 3 Issue 6, June 2018

Volume 3 Issue 6

Plasmodium of the apes

Sequencing of gorilla- and chimpanzee-infecting Plasmodium species elucidates the evolutionary history of the Laverania subgenus and highlights features of the human-infecting Plasmodium falciparum species that enable parasite transmission in humans.

See Otto et al.

Image: USO / iStock / Getty Images Plus / Getty. Cover Design: Samantha Whitham.

Editorial

  • Editorial |

    Although the spotlight on CRISPR–Cas systems has shone on their immense potential as genome-editing tools, the field’s origins are rooted in the microbiology of phage–bacterium interactions. Furthering our understanding of these processes can uncover more systems and generate new reagents with revolutionary properties.

News & Views

  • News & Views |

    Comparative genomics of all known Laverania species that infect African great apes reveals interspecies gene transfer and convergent evolution, and identifies features of Plasmodium falciparum, the only human-infective species within this subgenus, that may have led to its speciation and spread globally.

    • Jane M. Carlton
  • News & Views |

    Genetic integration of a humanized chemotaxis receptor unexpectedly reveals that a widely expressed immune protein is targeted by Staphylococcus aureus Panton–Valentine leukocidin in a novel way, changing our fundamental understanding of toxin–receptor biology and host–pathogen interaction.

    • Brandon Lee
    • Juliane Bubeck Wardenburg
  • News & Views |

    The discovery and characterization of a phylum-level archaeal lineage in iron-rich hot springs—the Marsarchaeota—expands the phylogenetic depth and physiological diversity of aerobic archaea.

    • Andreas Teske
  • News & Views |

    Antibodies that potently neutralize highly diverse HIV-1 variants offer great potential for therapy and prevention. Passive administration of HIV-specific neutralizing antibodies genetically modified to have a long serum half-life has now been shown to confer long-lasting protection from infection in the rhesus macaque model.

    • Michelle Zanoni
    • David Palesch
    • Guido Silvestri
  • News & Views |

    The small intestine microbiome has been revealed to play a critical role in nutritional signal transduction that enables the host to adapt its fat digestion and absorption capacities, suggesting that this microbial community may serve as a target to improve conditions of over- and undernutrition.

    • Michiel Kleerebezem

Reviews

  • Review Article |

    This Review Article details various methods that can be used for phylogeny-aware analyses of microbiome datasets, together with online tutorials, including the considerations and challenges of each method depending on the research question.

    • Alex D. Washburne
    • James T. Morton
    • Rob Knight

Research

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