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BACTERIAL PATHOGENESIS

A common approach to toxin specificity

Nature Microbiology volume 3, pages 644–645 (2018)Cite this article

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Genetic integration of a humanized chemotaxis receptor unexpectedly reveals that a widely expressed immune protein is targeted by Staphylococcus aureus Panton–Valentine leukocidin in a novel way, changing our fundamental understanding of toxin–receptor biology and host–pathogen interaction.

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Fig. 1: Model of bi-component pore formation using species-specific receptors.

References

  1. David, M. Z. & Daum, R. S. Curr. Top. Microbiol. Immunol. 409, 325–383 (2017).

    PubMed  Google Scholar 

  2. Spaan, A. N., van Strijp, J. A. G. & Torres, V. J. Nat. Rev. Microbiol. 15, 435–447 (2017).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  3. Shallcross, L. J., Fragaszy, E., Johnson, A. M. & Hayward, A. C. Lancet Infect. Dis. 13, 43–54 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Saeed, K. et al. Int. J. Antimicrob. Agents 51, 16–25 (2018).

    Article  PubMed  CAS  Google Scholar 

  5. Otto, M. Annu. Rev. Microbiol. 64, 143–162 (2010).

    Article  PubMed  CAS  Google Scholar 

  6. Spaan, A. N. et al. Cell Host Microbe 13, 584–594 (2013).

    Article  PubMed  CAS  Google Scholar 

  7. Tromp, A. T. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0159-x (2018).

  8. Rheinlander, A., Schraven, B. & Bommhardt, U. Immunol. Lett. 196, 22–32 (2018).

    Article  PubMed  CAS  Google Scholar 

  9. Song, L. et al. Science 274, 1859–1866 (1996).

    Article  PubMed  CAS  Google Scholar 

  10. Supersac, G., Prevost, G. & Piemont, Y. Infect. Immun. 61, 580–587 (1993).

    PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Growth, Development, and Disabilities Training Program, The University of Chicago, Chicago, IL, USA

    Brandon Lee

  2. The Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA

    Juliane Bubeck Wardenburg

Authors
  1. Brandon Lee
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  2. Juliane Bubeck Wardenburg
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Correspondence to Juliane Bubeck Wardenburg.

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The authors declare no competing interests.

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Lee, B., Bubeck Wardenburg, J. A common approach to toxin specificity. Nat Microbiol 3, 644–645 (2018). https://doi.org/10.1038/s41564-018-0173-z

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