Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Recently discovered type III-E CRISPR–Cas systems use the single Cas7-11 effector to cleave foreign RNA. Here the authors use cryo-electron microscopy and biochemical approaches to reveal the mechanisms underlying crRNA maturation, target RNA recognition and cleavage, and communication with the protease Csx29 by Cas7-11.
Combining simultaneous host and pathogen metagenomic profiles in a cohort of hospitalized and critically ill patients allows for more accurate diagnosis of sepsis.
Pandemic viruses cause major global disease burden and economic disruption. We investigated pandemic HIV-1(M) to understand its unique characteristics by comparing it with HIV strains that did not achieve pandemic human-to-human spread. We observed structural adaptations in the HIV-1(M) capsid that reduce detection by innate immune sensors.
Production of the enterotoxin tilimycin by gut-resident Klebsiella species can alter gut microbiota composition, induce mutational evolution and drive the emergence of antibiotic resistance in mice.
In this Perspective, the authors discuss the importance and current challenges of using genomic data to predict the emergence of infectious disease outbreaks, and propose the next steps to integrate genomics and modelling for infectious diseases forecasting.
Combined host transcriptional profiling and metagenomic pathogen detection of whole blood and plasma samples from critically ill patients enables the generation of classifiers for reliable prediction of sepsis.
Characterization of bacterial auxin degradation loci and their regulators reveals two distinct types across plant microbiome species, where only one, exemplified in Variovorax species, can interfere with root growth inhibition in a complex synthetic microbial community.
A CRISPR-based oligo recombineering (CORe) approach functionally prioritizes electrophile-sensitive cysteines in Toxoplasma gondii and promotes anti-parasitic drug discovery.
Detection of monkeypox viruses (MPXV) in archival testes samples from acute and convalescent MPXV-infected macaques provides evidence supporting the potential for sexual transmision of MPXV.
The authors review archaeal morphology, surface features, internal organization and cell division, discussing the state of the art and future research directions.
Longitudinal population deep sequencing of Streptococcus pneumoniae sampled from infants and their mothers improves our understanding of the dynamics of colonization, transmission, inter-strain competition and the impact of antibiotic treatment.
Comprenhensive analysis of human antibody responses to SARS-CoV-2 variants and animal sarbecoviruses finds that Omicron escapes neutralization more readily than distantly related animal sarbecoviruses.
The SIR2-domain-containing protein DSR2 from Bacillussubtilis protects against SPR phage infection via NAD+ depletion. Some phages express anti-DSR2 proteins, blocking bacterial immunity.