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Identification of divisome proteins related to human gephyrin and its membrane receptor in non-model Gram positive Corynebacteriales could provide new antibiotic targets for important pathogens including M. tuberculosis and C. diptheriae.
M3-seq uses combinatorial indexing alongside post hoc rRNA depletion in a single-cell RNA sequencing approach that reveals bacterial heterogeneity and rare populations during antibiotic stress and phage infection, as well as bet-hedging responses during growth.
Carbon catabolism of heterotrophic bacteria can be described using a simple general principle, which is their preference for either glycolytic (sugars) or gluconeogenic (amino and organic acids) carbon sources. This is reflected in their genomes via pathway abundances and GC content.
Investment in a new tuberculosis vaccine is a landmark step forward, but continued efforts to advance treatments, diagnostics and biosocial issues are needed to meet targets to end the epidemic by 2035.
The global outbreak of H5N1 highly pathogenic avian influenza virus and its high toll on animal populations raise concerns about spillover into humans, but human host barriers need to be considered when estimating transmission potential.
The Parkinson’s disease-associated leucine-rich repeat kinase 2 acts as a protein scaffold promoting mitochondria–Salmonella-containing vacuole tether formation and itaconate delivery to provide cell-intrinsic defence in Salmonella-infected macrophages.
Trehalose polyphleates are surface-exposed glycolipids that are required for successful infection by phages BPs and Muddy when infecting Mycobacterium abscessus and M. smegmatis.
Multi-cohort meta-analysis provides a framework for studies that aim to define causal relationships between the microbiome and autism spectrum disorder.
Prospective validation in the Democratic Republic of the Congo shows that implementation of nested polymerase chain reaction and nanopore sequencing is feasible in a national poliovirus laboratory
Filopodia-like extensions connect chikungunya virus-infected and non-infected cells and promote efficient viral transmission by shielding from neutralizing antibodies.
Carl Nathan describes how learning from Mycobacterium tuberculosis, which causes tuberculosis, teaches us about the intricacies of bacteria–immune system interplay and its repercussions for non-infectious diseases, including cancer.
Armillaria species, fungal pathogens prevalent in temperate forests, have acquired hundreds of genes from Ascomycota fungi through horizontal gene transfer. These genes have influenced Armillaria spp. pathogenicity and plant biomass degradation abilities and contribute to uncovering key insights into the evolutionary history and ecological effects of these fungi.
CRISPR systems canonically confer microorganisms with protection against invading viral DNA, plasmids and mobile genetic elements, however a multi-omics investigation of deep subsurface archaeal communities suggests that archaeal CRISPR systems might target other archaeal parasites or force a transition from parasitism to mutualism.
Chitin-degrading bacteria split into on- and away-from-particles subpopulations. Only on-particle cells grow and most disperse after replication, leaving chitinases behind. High dispersal is sustained by remaining cells thriving on leftover chitinases.