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Application of single-molecule methods to assay genome-wide mRNA and protein levels in single bacteria provides a systems-level view of their relationship.
A Human Proteome Project has been proposed. To ensure that such a project will have a transformative impact on biology, its scope should be determined by wide and open discussion.
Mass spectrometry has evolved and matured to a level where it is able to assess the complexity of the human proteome. We discuss some of the expected challenges ahead and promising strategies for success.
Analysis of RNA sequencing data points to fewer intergenic transcripts than assumed. Isolating them via chromatin association may enrich for functional noncoding transcripts.
To site-specifically label proteins in living cells, researchers mutate an enzyme to recognize a small fluorophore and catalyze its attachment to a small peptide tag.