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An improved analysis approach for single-wavelength anomalous diffraction (SAD)-based macromolecular X-ray structure determination expands the applicability of this phasing method for macromolecules with weak anomalous signals.
A native-SAD (single-wavelength anomalous diffraction) data collection strategy enables phasing using anomalous signal from a single native crystal, facilitating straightforward macromolecular X-ray structure determination.
Snap-tag reporter mice allow flexible yet efficient targeting of chemical indicators to genetically labeled cells in vivo. With this strategy, cells can either be labeled fluorescently or ablated using the same reporter.
A DNA nanoswitch platform enables inexpensive kinetic and thermodynamic analysis of a range of biomolecular interactions using a simple gel electrophoresis readout.
The Archaea metalloproteinase LysargiNase increases proteome coverage, identifies more C-terminal peptides from proteins and improves methylated peptide identification.
A genetically encoded peroxidase with improved sensitivity, APEX2, is reported for electron microscopy and proximity labeling at low expression levels.
Acoustic force spectroscopy applies acoustic forces across a large dynamic range for highly multiplexed single-molecule measurements in a simple, compact setup.
The open-source DIAMOND software provides protein alignment that is 20,000 times faster on short reads than BLASTX at similar sensitivity, for rapid analysis of large metagenomics data sets on a desktop computer.
Serial femtosecond crystallography experiments with diverse protein microcrystal suspensions are facilitated using a grease matrix as a carrier medium for sample injection.
Results show the minimum sequencing depth required for the discovery of differentially methylated regions at desired sensitivity and specificity and the trade-off between adding more replicates versus increasing sequencing depth.
This paper investigates the stress levels and behavior of wild animals when approached by remote-operated vehicles versus humans for data collection in field research
Quantum dot–coated pipettes facilitate targeted electrophysiological recordings in deep brain tissue because they are readily visible owing to the strong two-photon fluorescence of the quantum dots.
Avoiding nonspecific binding is essential for performing fluorescence microscopy–based analyses of single molecules tethered to surfaces. A dichlorodimethylsilane–Tween-20–passivated surface provides a useful alternative to the standard poly(ethylene glycol) surface for single-molecule studies.
A method based on the Hadamard transform is shown to enable time-resolved X-ray crystallography measurements of protein dynamics at standard synchrotron sources.
Communications between animals such as zebra finches can be discriminated with back-attached acceleration recorders. In contrast to microphones, these devices record the carrier's signals only, allowing a more precise analysis of individual vocalizations during social interactions.
The CONCOCT software performs unsupervised binning of metagenomic contigs across multiple samples to allow better genome reconstruction from microbial communities.