Image: Shira Friedman. Cover design: Erin Dewalt.

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Latest Research

  • Article |

    It remains impossible using conventional Hi-C to differentiate interactions between and along sister chromatids. SisterC relies on selective destruction of nascent DNA and in combination with Hi-C offers a means to study intra- and inter-sister interactions independently.

    • Marlies E. Oomen
    • , Adam K. Hedger
    • , Jonathan K. Watts
    •  & Job Dekker
  • Article |

    Plasmonic scattering microscopy (PSM) enables the imaging of single proteins on SPR instruments. The method enables measurement of protein size and binding kinetics and is fully compatible with simultaneous traditional SPR measurements.

    • Pengfei Zhang
    • , Guangzhong Ma
    • , Wei Dong
    • , Zijian Wan
    • , Shaopeng Wang
    •  & Nongjian Tao
  • Article |

    Antigen-specific CD8+ T cells can be imaged by immunoPET with the help of synTacs, MHC-based tools that bind to relevant T-cell receptors.

    • Andrew W. Woodham
    • , Stad H. Zeigler
    • , Ella L. Zeyang
    • , Stephen C. Kolifrath
    • , Ross W. Cheloha
    • , Mohammad Rashidian
    • , Rodolfo J. Chaparro
    • , Ronald D. Seidel
    • , Scott J. Garforth
    • , Jason L. Dearling
    • , Maia Mesyngier
    • , Phaneendra K. Duddempudi
    • , Alan B. Packard
    • , Steven C. Almo
    •  & Hidde L. Ploegh
  • Article |

    Tension-PAINT integrates molecular tension probes with DNA-PAINT to enable ~25-nm-resolution mapping of piconewton mechanical events. Tension-PAINT can be used to study dynamic forces, and an irreversible variant integrates force history over time.

    • Joshua M. Brockman
    • , Hanquan Su
    • , Aaron T. Blanchard
    • , Yuxin Duan
    • , Travis Meyer
    • , M. Edward Quach
    • , Roxanne Glazier
    • , Alisina Bazrafshan
    • , Rachel L. Bender
    • , Anna V. Kellner
    • , Hiroaki Ogasawara
    • , Rong Ma
    • , Florian Schueder
    • , Brian G. Petrich
    • , Ralf Jungmann
    • , Renhao Li
    • , Alexa L. Mattheyses
    • , Yonggang Ke
    •  & Khalid Salaita
  • Brief Communication |

    MassIVE.quant is a data repository and data resource for reproducible quantitative mass spectrometry–based proteomics.

    • Meena Choi
    • , Jeremy Carver
    • , Cristina Chiva
    • , Manuel Tzouros
    • , Ting Huang
    • , Tsung-Heng Tsai
    • , Benjamin Pullman
    • , Oliver M. Bernhardt
    • , Ruth Hüttenhain
    • , Guo Ci Teo
    • , Yasset Perez-Riverol
    • , Jan Muntel
    • , Maik Müller
    • , Sandra Goetze
    • , Maria Pavlou
    • , Erik Verschueren
    • , Bernd Wollscheid
    • , Alexey I. Nesvizhskii
    • , Lukas Reiter
    • , Tom Dunkley
    • , Eduard Sabidó
    • , Nuno Bandeira
    •  & Olga Vitek

News & Comment

  • This Month |

    Frugally built technology to study the ocean’s microbes, and engineering for societal good.

    • Vivien Marx
  • Research Highlight |

    Addition of a second constriction to CsgG-family nanopores improves the accuracy of homopolymer sequencing.

    • Arunima Singh
  • Editorial |

    We distributed an informal questionnaire to learn from scientists about their professional use of WeChat. We share some of their answers and discuss the multipurpose platform offered by WeChat.

Collection

Expanding the CRISPR Toolbox

The CRISPR-Cas9 system is best known for its ability to knock out or replace specific genes, via targeted cleavage of the genome. But scientists are developing many more applications, typically by using an inactive Cas9 to target other enzymes to specific genomic sites. From transcriptional regulation to base editing, these developments are extending the range of biological questions that can be probed with CRISPR/Cas9.

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