Volume 21
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No. 4 April 2024
Advanced nanopore-based peptide sequencingPeptide sequencing by nanopore: a crow drops grapes into a pitcher with a narrow neck, representing the cleavage of a peptide into amino acids and their subsequent detection by a modified nanopore.
See Zhang et al.
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No. 3 March 2024
Brighter autonomous bioluminescenceAutonomously glowing Arabidopsis thaliana plants express an improved version of the fungal bioluminescence pathway.
See Shakhova et al.
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No. 2 February 2024
Smart lattice light-sheet microscopySmart lattice light-sheet microscopy captures rare cellular events. The image shows immune synapses formed between cytotoxic T lymphocytes (cyan) and tumor cells (magenta) within a population of cultured cells. Cytotoxic granules are shown in yellow.
See Shi et al.
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No. 1 January 2024
Integrated protein structure modeling for cryo-EMDeepMainmast builds structures of protein complexes from cryo-electron microscopy maps. It uses deep learning to identify key atom positions in the density, which are then connected to build fragment structures. Fragments are combined into a full structure, which is refined to atomic detail.
See Terashi et al.