Method of the Year 2020: spatially resolved transcriptomics

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  • Method to Watch |

    Glycoproteomics is coming of age, thanks to advances in instrumentation, experimental methodologies and computational search algorithms.

    • Arunima Singh
  • Method to Watch |

    Organoids generated by spatially organizing multiple cell types, called assembloids, will enable deeper insights into tissue function.

    • Nina Vogt
  • Method to Watch |

    Computational approaches help us explore complexities of the T cell receptor repertoire.

    • Madhura Mukhopadhyay
  • Method to Watch |

    Method development pushes the limit of completeness of genome sequences.

    • Lin Tang

Collection

Expanding the CRISPR Toolbox

The CRISPR-Cas9 system is best known for its ability to knock out or replace specific genes, via targeted cleavage of the genome. But scientists are developing many more applications, typically by using an inactive Cas9 to target other enzymes to specific genomic sites. From transcriptional regulation to base editing, these developments are extending the range of biological questions that can be probed with CRISPR/Cas9.

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