Volume 19 Issue 5, May 2020

Volume 19 Issue 5

Nanoparticle entry into tumours

The dominant mechanism of nanoparticle entry into solid tumours has now been shown to be an active trans-endothelial pathway rather than the currently established passive transport via inter-endothelial gaps.

See Chan, Mooney and Nie

Image: Benjamin Kingston and Shrey Sindhwani, University of Toronto. Cover Design: Alex Wing

Editorial

  • Editorial |

    A collective effort from materials scientists, life scientists and clinicians is required to systematically address fundamental questions in the mechanisms of nanoparticle delivery in order to overcome the hurdles in translating nanomedicines for tumour therapy.

Comment

  • Comment |

    New evidence suggests that the mechanism of nanoparticle entry into solid tumours may be driven by an active process. This insight paves the way for approaches to enhance the efficiency of nanomedicine delivery by harnessing active transport mechanisms, and encourage researchers to rethink how tumours are treated.

    • Subehndu Pandit
    • , Debapriya Dutta
    •  & Shuming Nie

News & Views

  • News & Views |

    Two distinct topological states that are closely tied to the spin configurations of a layered compound, here MnBi2Te4, have been demonstrated. Such control of the topological state should enable new opportunities to realize quantum and spintronic devices.

    • Peng Wei
    •  & Jagadeesh S. Moodera
  • News & Views |

    Finding a competitor for diamond as a good heat conductor remains challenging. Measurements on crystals of cubic boron nitride demonstrate a thermal conductivity of 1,600 W m−1 K−1 at room temperature, rivalling diamond.

    • Ashutosh Giri
    •  & Patrick E. Hopkins
  • News & Views |

    A monolayer topological insulator is magnetized by proximity to a layered antiferromagnetic insulator.

    • Cui-Zu Chang
  • News & Views |

    New evidence now suggests that the dominant mechanism of extravasation of nanoparticles into solid tumours may be through an active process of endothelial transcytosis.

    • Irene de Lázaro
    •  & David J. Mooney
  • News & Views |

    Two studies shed light on quantum defects in two-dimensional hexagonal boron nitride, identifying an optically addressable spin centre at room temperature and offering microscopic insights into different classes of single-photon emitters.

    • M. E. Turiansky
    • , A. Alkauskas
    •  & C. G. Van de Walle

Review Articles

  • Review Article |

    Organic semiconductors are making their way into applications ranging from display technology to flexible electronics and biomedical applications. This Review discusses current understanding of charge carrier transport in these materials and strategies to improve their performance.

    • Simone Fratini
    • , Mark Nikolka
    • , Alberto Salleo
    • , Guillaume Schweicher
    •  & Henning Sirringhaus

Letters

  • Letter |

    Quantum-assisted de-trapping in tungsten leads to diffusion rates orders of magnitude higher than naive classical estimates suggest. This phenomenon may be generic to any crystalline material.

    • Kazuto Arakawa
    • , Mihai-Cosmin Marinica
    • , Steven Fitzgerald
    • , Laurent Proville
    • , Duc Nguyen-Manh
    • , Sergei L. Dudarev
    • , Pui-Wai Ma
    • , Thomas D. Swinburne
    • , Alexandra M. Goryaeva
    • , Tetsuya Yamada
    • , Takafumi Amino
    • , Shigeo Arai
    • , Yuta Yamamoto
    • , Kimitaka Higuchi
    • , Nobuo Tanaka
    • , Hidehiro Yasuda
    • , Tetsuya Yasuda
    •  & Hirotaro Mori
  • Letter |

    The contribution of non-ideal mixing for the crystallization of supercooled mixtures of argon and krypton is reported, showing that this process is well described by classical crystal growth theories when such thermodynamics is considered.

    • Alexander Schottelius
    • , Francesco Mambretti
    • , Anton Kalinin
    • , Björn Beyersdorff
    • , Andre Rothkirch
    • , Claudia Goy
    • , Jan Müller
    • , Nikolaos Petridis
    • , Maurizio Ritzer
    • , Florian Trinter
    • , José M. Fernández
    • , Tiberio A. Ezquerra
    • , Davide E. Galli
    •  & Robert E. Grisenti
  • Letter |

    Nitrogenases use transition metals to selectively capture weak π acids such as N2 by employing backbonding interactions. Here, a metal–organic framework with exposed vanadium sites is presented that uses this approach for selective capture of N2 from CH4, with impressive selectivity and capacity.

    • David E. Jaramillo
    • , Douglas A. Reed
    • , Henry Z. H. Jiang
    • , Julia Oktawiec
    • , Michael W. Mara
    • , Alexander C. Forse
    • , Daniel J. Lussier
    • , Ryan A. Murphy
    • , Marc Cunningham
    • , Valentina Colombo
    • , David K. Shuh
    • , Jeffrey A. Reimer
    •  & Jeffrey R. Long
  • Letter |

    A large longitudinal resistance and zero Hall plateau—hallmarks of an axion insulator—are found in MnBi2Te4. Moreover, a moderate magnetic field drives a quantum phase transition to a Chern insulator phase with zero longitudinal resistance and quantized Hall resistance h/e2.

    • Chang Liu
    • , Yongchao Wang
    • , Hao Li
    • , Yang Wu
    • , Yaoxin Li
    • , Jiaheng Li
    • , Ke He
    • , Yong Xu
    • , Jinsong Zhang
    •  & Yayu Wang

Articles

  • Article |

    The bandgap of 2D molybdenum disulfide can be tuned uniformly, reproducibly and precisely over a large range by using a glass sphere support and changing the diameter of the spheres.

    • Mengqi Zeng
    • , Jinxin Liu
    • , Lu Zhou
    • , Rafael G. Mendes
    • , Yongqi Dong
    • , Min-Ye Zhang
    • , Zhi-Hao Cui
    • , Zhonghou Cai
    • , Zhan Zhang
    • , Daming Zhu
    • , Tieying Yang
    • , Xiaolong Li
    • , Jianqiang Wang
    • , Liang Zhao
    • , Guoxian Chen
    • , Hong Jiang
    • , Mark H. Rümmeli
    • , Hua Zhou
    •  & Lei Fu
  • Article |

    Defects in hexagonal boron nitride exhibit room-temperature quantum emission, but their unknown structural origin challenges their technological utility. A combination of optical and electron microscopy helps to distinguish at least four classes of defects and correlate them with local strain.

    • Fariah Hayee
    • , Leo Yu
    • , Jingyuan Linda Zhang
    • , Christopher J. Ciccarino
    • , Minh Nguyen
    • , Ann F. Marshall
    • , Igor Aharonovich
    • , Jelena Vučković
    • , Prineha Narang
    • , Tony F. Heinz
    •  & Jennifer A. Dionne
  • Article |

    An ensemble of spins associated with an intrinsic defect of two-dimensional hexagonal boron nitride is shown to be optically addressable, allowing spin polarization of its triplet ground state and providing evidence of spin coherence.

    • Andreas Gottscholl
    • , Mehran Kianinia
    • , Victor Soltamov
    • , Sergei Orlinskii
    • , Georgy Mamin
    • , Carlo Bradac
    • , Christian Kasper
    • , Klaus Krambrock
    • , Andreas Sperlich
    • , Milos Toth
    • , Igor Aharonovich
    •  & Vladimir Dyakonov
  • Article |

    A superconducting transition is used to switch a single molecule magnet from a blocked magnetization state to a resonant quantum tunnelling regime

    • Giulia Serrano
    • , Lorenzo Poggini
    • , Matteo Briganti
    • , Andrea Luigi Sorrentino
    • , Giuseppe Cucinotta
    • , Luigi Malavolti
    • , Brunetto Cortigiani
    • , Edwige Otero
    • , Philippe Sainctavit
    • , Sebastian Loth
    • , Francesca Parenti
    • , Anne-Laure Barra
    • , Alessandro Vindigni
    • , Andrea Cornia
    • , Federico Totti
    • , Matteo Mannini
    •  & Roberta Sessoli
  • Article |

    The electrochemical performance of supercapacitors can be enhanced with porous electrodes. Molecular dynamics simulations can now help to clarify the double-layer structure and capacitive performance of supercapacitors composed of MOF electrodes and ionic liquid electrolytes.

    • Sheng Bi
    • , Harish Banda
    • , Ming Chen
    • , Liang Niu
    • , Mingyu Chen
    • , Taizheng Wu
    • , Jiasheng Wang
    • , Runxi Wang
    • , Jiamao Feng
    • , Tianyang Chen
    • , Mircea Dincă
    • , Alexei A. Kornyshev
    •  & Guang Feng
  • Article |

    Photocatalysts formed from a single organic semiconductor can suffer from inefficient charge generation leading to low photocatalytic activities. Incorporating a heterojunction between a donor polymer and non-fullerene acceptor in organic nanoparticles leads to enhanced photocatalytic hydrogen evolution.

    • Jan Kosco
    • , Matthew Bidwell
    • , Hyojung Cha
    • , Tyler Martin
    • , Calvyn T. Howells
    • , Michael Sachs
    • , Dalaver H. Anjum
    • , Sandra Gonzalez Lopez
    • , Lingyu Zou
    • , Andrew Wadsworth
    • , Weimin Zhang
    • , Lisheng Zhang
    • , James Tellam
    • , Rachid Sougrat
    • , Frédéric Laquai
    • , Dean M. DeLongchamp
    • , James R. Durrant
    •  & Iain McCulloch
  • Article |

    The dominant mechanism of nanoparticle entry into solid tumours has now been shown to be an active trans-endothelial pathway rather than the currently established passive transport via inter-endothelial gaps.

    • Shrey Sindhwani
    • , Abdullah Muhammad Syed
    • , Jessica Ngai
    • , Benjamin R. Kingston
    • , Laura Maiorino
    • , Jeremy Rothschild
    • , Presley MacMillan
    • , Yuwei Zhang
    • , Netra Unni Rajesh
    • , Tran Hoang
    • , Jamie L. Y. Wu
    • , Stefan Wilhelm
    • , Anton Zilman
    • , Suresh Gadde
    • , Andrew Sulaiman
    • , Ben Ouyang
    • , Zachary Lin
    • , Lisheng Wang
    • , Mikala Egeblad
    •  & Warren C. W. Chan

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