Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer nanomedicine

A nanoparticle’s pathway into tumours

New evidence now suggests that the dominant mechanism of extravasation of nanoparticles into solid tumours may be through an active process of endothelial transcytosis.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Mechanisms of nanoparticle tumour extravasation.

References

  1. Gerlowski, L. E. & Jain, R. K. Microvasc. Res. 31, 288–305 (1986).

    Article  CAS  Google Scholar 

  2. Matsumura, Y. & Maeda, H. Cancer Res. 46, 6387–6392 (1986).

    CAS  Google Scholar 

  3. Hobbs, S. K. et al. Proc. Natl Acad. Sci. USA 95, 4607–4612 (1998).

    Article  CAS  Google Scholar 

  4. Wilhelm, S. et al. Nat. Rev. Mater. 1, 16014 (2016).

    Article  CAS  Google Scholar 

  5. Anselmo, A. C. & Mitragotri, S. Bioeng. Transl. Med. 4, e10143 (2019).

    Google Scholar 

  6. Shi, J., Kantoff, P. W., Wooster, R. & Farokhzad, O. C. Nat. Rev. Cancer 17, 20–37 (2017).

    Article  CAS  Google Scholar 

  7. Petersen, G. H., Alzghari, S. K., Chee, W., Sankari, S. S. & La-Beck, N. M. J. Control Release. 232, 255–264 (2016).

    Article  CAS  Google Scholar 

  8. Nel, A., Ruoslahti, E. & Meng, H. ACS Nano. 11, 9567–9569 (2017).

    Article  CAS  Google Scholar 

  9. Sindhwani, S. et al. Nat. Mater. https://doi.org/10.1038/s41563-019-0566-2 (2019).

    Article  Google Scholar 

  10. McNeil, S. E. Nat. Rev. Mater. 1, 16073 (2016).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David J. Mooney.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

de Lázaro, I., Mooney, D.J. A nanoparticle’s pathway into tumours. Nat. Mater. 19, 486–487 (2020). https://doi.org/10.1038/s41563-020-0669-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41563-020-0669-9

This article is cited by

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research