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Volume 19 Issue 5, May 2020

Nanoparticle entry into tumours

The dominant mechanism of nanoparticle entry into solid tumours has now been shown to be an active trans-endothelial pathway rather than the currently established passive transport via inter-endothelial gaps.

See Chan, Mooney and Nie

Image: Benjamin Kingston and Shrey Sindhwani, University of Toronto. Cover Design: Alex Wing

Volume 19 Issue 5

Editorial

  • A collective effort from materials scientists, life scientists and clinicians is required to systematically address fundamental questions in the mechanisms of nanoparticle delivery in order to overcome the hurdles in translating nanomedicines for tumour therapy.

    Editorial

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Comment

  • New evidence suggests that the mechanism of nanoparticle entry into solid tumours may be driven by an active process. This insight paves the way for approaches to enhance the efficiency of nanomedicine delivery by harnessing active transport mechanisms, and encourage researchers to rethink how tumours are treated.

    • Subehndu Pandit
    • Debapriya Dutta
    • Shuming Nie
    Comment
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News & Views

  • Two distinct topological states that are closely tied to the spin configurations of a layered compound, here MnBi2Te4, have been demonstrated. Such control of the topological state should enable new opportunities to realize quantum and spintronic devices.

    • Peng Wei
    • Jagadeesh S. Moodera
    News & Views
  • Finding a competitor for diamond as a good heat conductor remains challenging. Measurements on crystals of cubic boron nitride demonstrate a thermal conductivity of 1,600 W m−1 K−1 at room temperature, rivalling diamond.

    • Ashutosh Giri
    • Patrick E. Hopkins
    News & Views
  • A monolayer topological insulator is magnetized by proximity to a layered antiferromagnetic insulator.

    • Cui-Zu Chang
    News & Views
  • New evidence now suggests that the dominant mechanism of extravasation of nanoparticles into solid tumours may be through an active process of endothelial transcytosis.

    • Irene de Lázaro
    • David J. Mooney
    News & Views
  • Two studies shed light on quantum defects in two-dimensional hexagonal boron nitride, identifying an optically addressable spin centre at room temperature and offering microscopic insights into different classes of single-photon emitters.

    • M. E. Turiansky
    • A. Alkauskas
    • C. G. Van de Walle
    News & Views
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Letters

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Amendments & Corrections

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