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Despite exciting progress in the biology underlying a variety of proposed molecular medicines, an unmet challenge Remains—delivery. This problem, how to better target the new generation of therapeutics, cuts across all diseases. The solution offers unprecedented opportunities for multidisciplinary teams of bioengineers to work with biological and medical scientists to realize the fruits of our nation's investment in molecular and cellular medicine.
Transgenic mice that overexpress calcineurin develop cardiac hypertrophy, which can be prevented by treatment with immunosuppressive drugs that inhibit calcineurin.
Mathematical models that predict epidemiological outcomes in the treatment of viral infections enable prospective evaluation of complex public health decisions (pages 673–678).
Deamidation of wheat gliadin by tissue transglutaminase promotes its binding to HLA-DQ2 and its recognition by gut T cells, suggesting a novel mechanism in celiac disease (pages 713–717).
Embryonic striatal neurons transplanted into marmoset brains become integrated into host tissue and induce functional recovery in a primate model of Huntington's disease (pages 727–729).
