Volume 11 Issue 12, 1 December 2005


Brief Communication


Technical Report




Book Review

News & Views

  • News & Views |

    Maintenance of the retinal vasculature protects against proliferative retinopathy and blindness. Lipids and free radicals together modulate vascular stability through regulation of antiangiogenic proteins ( pages 1339–1345 ).

    • Lois E H Smith
    •  & Kip M Connor
  • News & Views |

    Treatment with a neuronal growth factor stimulates weight loss—and spurs the development of new neurons that help maintain reduced weight.

    • Randy J Seeley
  • News & Views |

    Low levels of DNA damage caused by oxidative stress can be repaired, whereas extensive damage usually results in cell death. p53 contributes to both outcomes by stimulating expression of either pro- or antioxidant genes ( pages 1306–1313 ).

    • Karim Bensaad
    •  & Karen H Vousden
  • News & Views |

    Abdominal aortic aneurysms arise from chronic, irreversible destruction of connective tissue. A promising pharmacologic approach not only suppresses development of aneurysms, but also induces regression ( pages 1330–1338 ).

    • Robert W Thompson
  • News & Views |

    Emotional stress may increase anxiety, but in mice, a different kind of stress—oxidative stress—may also contribute to anxious behavior.

    • Jay A Gingrich
  • News & Views |

    A rare memory stem cell has been discovered that sustains graft-versus-host disease in animal models ( pages 1299–1305 )

    • Xue-Zhong Yu
    •  & Claudio Anasetti
  • News & Views |

    Local levels of cAMP regulate the precise opening of the ryanodine receptor complex—which releases calcium at the start of a heartbeat. Loss or inhibition of phosphodiesterase 4D enzymatic activity leads to calcium leak, heart failure and arrhythmia.

    • Jeffery D Molkentin