Reviews & Analysis

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  • We developed and validated a deep learning system (termed DeepDR Plus) in a diverse, multiethnic, multi-country dataset to predict personalized risk and time to progression of diabetic retinopathy. We show that DeepDR Plus can be integrated into the clinical workflow to promote individualized intervention strategies for the management of diabetic retinopathy.

    Research Briefing
  • New data show that electronic clinical decision support systems integrated with point-of-care tests can lead to meaningful reductions in antibiotic use in children in low- and middle-income countries, without compromising health outcomes — but investment in human resources is crucial to their success.

    • Sena Sayood
    • Julia Bielicki
    • Sumanth Gandra
    News & Views
  • This year brought wins for artificial intelligence, genomics and gene editing, and breakthroughs in understanding diseases whose underpinnings have long eluded scientists. Here is our selection of critical developments that moved medicine forward in 2023.

    • Karen O’Leary
    Year in Review
  • This year brought wins for artificial intelligence, genomics and gene editing, and breakthroughs in understanding diseases whose underpinnings have long eluded scientists. Here is our selection of critical developments that moved medicine forward in 2023.

    • Karen O’Leary
    Year in Review
  • This year brought wins for artificial intelligence, genomics and gene editing, and breakthroughs in understanding diseases whose underpinnings have long eluded scientists. Here is our selection of critical developments that moved medicine forward in 2023.

    • Karen O’Leary
    Year in Review
  • This year brought wins for artificial intelligence, genomics and gene editing, and breakthroughs in understanding diseases whose underpinnings have long eluded scientists. Here is our selection of critical developments that moved medicine forward in 2023.

    • Karen O’Leary
    Year in Review
  • This year brought wins for artificial intelligence, genomics and gene editing, and breakthroughs in understanding diseases whose underpinnings have long eluded scientists. Here is our selection of critical developments that moved medicine forward in 2023.

    • Karen O’Leary
    Year in Review
  • This year brought wins for artificial intelligence, genomics and gene editing, and breakthroughs in understanding diseases whose underpinnings have long eluded scientists. Here is our selection of critical developments that moved medicine forward in 2023.

    • Karen O’Leary
    Year in Review
  • This year brought wins for artificial intelligence, genomics and gene editing, and breakthroughs in understanding diseases whose underpinnings have long eluded scientists. Here is our selection of critical developments that moved medicine forward in 2023.

    • Karen O’Leary
    Year in Review
  • This year brought wins for artificial intelligence, genomics and gene editing, and breakthroughs in understanding diseases whose underpinnings have long eluded scientists. Here is our selection of critical developments that moved medicine forward in 2023.

    • Karen O’Leary
    Year in Review
  • This year brought wins for artificial intelligence, genomics and gene editing, and breakthroughs in understanding diseases whose underpinnings have long eluded scientists. Here is our selection of critical developments that moved medicine forward in 2023.

    • Karen O’Leary
    Year in Review
  • This year brought wins for artificial intelligence, genomics and gene editing, and breakthroughs in understanding diseases whose underpinnings have long eluded scientists. Here is our selection of critical developments that moved medicine forward in 2023.

    • Karen O’Leary
    Year in Review
  • Evidence supports the use of primary HPV testing to accelerate the global elimination of cervical cancer, but such recommendations must be viewed in the context of the fragile healthcare systems and complex implementation challenges in low-income and lower-middle income countries.

    • Diama Bhadra Vale
    • Julio Cesar Teixeira
    News & Views
  • The authors discuss how screening strategies, treatment approaches and precision oncology are evolving in China and outline trends and priorities in the drug development and regulatory landscape.

    • Zhihao Lu
    • Yang Chen
    • Lin Shen
    Review Article
  • Glial cells influence brain function and disease progression. This study identifies signals that elicit hemorrhage-specific glia plasticity, including proliferation and the acquisition of neural stem cell properties. It thereby sets a foundation for aligning glia reactivity with disease progression and for attempting to use this endogenous stem cell pool for brain repair.

    Research Briefing
  • Research participants often do not represent the target population for treatment. Systematic exclusion of particular groups limits the generalizability of research and perpetuates health inequalities. The REP-EQUITY toolkit guides representative and equitable inclusion in research. Its use may promote trust between communities and research institutions and improve the applicability of research findings.

    Research Briefing
  • Nature Medicine asks leading researchers to name their top clinical trial for 2024, from base editing and a vaccine against HIV to artificial intelligence tools for lung cancer and patient triage.

    • Carrie Arnold
    • Paul Webster
    Year in Review
  • A prognostic model for invasive breast cancer that is based on interpretable measurements of epithelial, stromal, and immune components outperforms histologic grading by expert pathologists. This model could improve clinical management of patients diagnosed with invasive breast cancer and address the concerns of pathologists about artificial intelligence (AI) trustworthiness by providing transparent and explainable predictions.

    Research Briefing