Glial cells influence brain function and disease progression. This study identifies signals that elicit hemorrhage-specific glia plasticity, including proliferation and the acquisition of neural stem cell properties. It thereby sets a foundation for aligning glia reactivity with disease progression and for attempting to use this endogenous stem cell pool for brain repair.
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References
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This is a summary of: Sirko, S. et al. Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain. Nat. Med. https://doi.org/10.1038/10.1038/s41591-023-02644-6 (2023).
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Injury-specific signals elicit plasticity in glial cells from patients with brain injury. Nat Med 29, 3018–3019 (2023). https://doi.org/10.1038/s41591-023-02647-3
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DOI: https://doi.org/10.1038/s41591-023-02647-3
