Reviews & Analysis

A method for preventing lens epithelial cell growth following cataract surgery suggests a novel way to deliver drugs to the eye (pages 1026–1028).

T lymphocytes produce opioid immunopeptides that control pain at sites of inflammation

Suicidal donor T lymphocytes halt GvHD thereby favoring the graft-versus-tumor effect in allogeneic BMT patients.

The large T antigen of SV40 virus may promote the development of mesotheliomas by interacting with and inactivating tumor suppressor proteins (pages 908–916).

The finding that dengue viruses use heparan sulfate to enter cells may alter our understanding of their pathogenesis and aid in vaccine development (pages 866–871).

Antisense approaches and decoy strategies are at the heart of new pre-clinical studies (pages 894–903).

Biochemical and molecular analyses of the Interaction of AZT monophosphate with thymldylate klnase provide novel Insights Into the limited clinical efficacy of AZT (pages 922–924).

Two recent studies demonstrate how sequence motifs in bacterial DNA can activate the immune system, causing both beneficial as well as deleterious consequences (pages 849–854).

Although originally isolated from bone, BMPs control the growth, development and repair of a wide range of different tissues.

p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair.

Transplants of fibroblasts secreting high levels of β-glucuronidase decrease lesions in the brains of mice with Sly syndrome, a lysososmal storage disease (771–774).

Tansglutaminase is identified as the autoantigen or celiac disease (pages 797–801).

Transplanted grafts of pancreatic islet cells engineered to express Fas ligand are destroyed not protected by the immune system (pages 738–743).

The first gene involved in mammalian circadian timekeeping has been identified.

Neuropeptide Y may act as an endogenous anticonvulsant through Y5 receptors suggesting a new target for antiepileptic drugs (pages 761–764).

Accumulating evidence from several studies points to the normal function of presenilin 1 and suggests how the mutant protein contributes to deposition of amyloid plaques in Alzheimer's disease (pages 756–760).

Altered expression of adhesion molecules on fetal cytotrophoblasts is essential for development of a normal placenta and fails in pre-eclampsia.

Retinoic acid reverses elastase-induced emphysema in rats by stimulating an increase in the number of lung alveoli (675–677).

Replication of HIV-1 is halted in human CD4⁴ T cells engineered to express interleukin 16, suggesting a novel gene therapy approach to combat HIV infection (659–664).