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BMPs: Actions in flesh and bone

Although originally isolated from bone, BMPs control the growth, development and repair of a wide range of different tissues.

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References

  1. Nusslein-Vollhard, C. & Wieschaus, E. Mutations affecting segment number and polarity in Drosophila. Nature 287, 795–801 (1980).

    Article  Google Scholar 

  2. Urist, M.R. Bone: Formation by autoinduction. Science. 150, 893–899 (1965).

    Article  CAS  Google Scholar 

  3. Reddi, A.H. & Huggins, C.B. Biochemical sequences in the transformation of normal fibroblasts in adolescent rat. Proc. Nat. Acad. Sci. USA. 69, 1601–1605 (1972).

    Article  CAS  Google Scholar 

  4. Reddi, A.H. Cell biology and biochemistry of endo-chondral bone development. Coll. Rel. Res. 1, 209–226 (1981).

    Article  CAS  Google Scholar 

  5. Reddi, A.H. Bone: Proteins: an unconventional approach to isolation of first mammalian morphogens. Cytokine Growth Factor Review. 8, 11–20 (1997).

    Article  CAS  Google Scholar 

  6. Dudley, A.T., Lyons, K.M. & Robertson, E.J. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Cenes and Development. 9, 2795–2807 (1995).

    CAS  Google Scholar 

  7. Luo, G. et al. BMP-7 is an inducer of nephrogenesis and is also required for eye development and skeletal patterning. Genes & Development. 9, 2808–2820 (1995).

    Article  CAS  Google Scholar 

  8. Paralkar, V.M., Weeks, B.S., Yu, Y.M., Kleinman, H.K. & Reddi, A.H. Recombinant human bone morphogenetic protein 2B (BMP-4) stimulator of PCI 2 Cell Differentiation: Potentiation and binding to type IV collagen. J. Cell Biol. 119, 1721–1728 (1992).

    Article  CAS  Google Scholar 

  9. Savage, C., Das, P., Finelli, A.L. & Padget, R. Caenorhabditis elegans genes Sma-2, Smo-3, and Sma-4 define a conserved family of transforming growth factor-(pathway components. Proc. Nat. Acad. Sd. USA 93, 790–794 (1996).

    Article  CAS  Google Scholar 

  10. Wrana, J. & Pawson, T. Mad about SMADs. Nature 388, 28–29 (1997)

    Article  CAS  Google Scholar 

  11. Nakao, A. et al. TGF-(receptor-mediated signaling through Smad 2, Smad 3, and Smad-4. Embo J. (in press)

  12. Hayashi, H. et al. The mad-related protein Smad-7 associates with the TGF-(receptor and functions as an antagonist of TCF-(signaling). Cell. 89, 1165–1173 (1997).

    Article  CAS  Google Scholar 

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Reddi, A. BMPs: Actions in flesh and bone. Nat Med 3, 837–839 (1997). https://doi.org/10.1038/nm0897-837

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