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A combination of clinical and molecular analyses supports an association between disorders of immune complement or coagulation with poor outcome in patients with SARS-CoV-2 infection.
An antisense oligonucleotide induces exon skipping in cell lines derived from patients with CLN3 Batten disease, and reduces lysosomal impairment and ameliorates neurological phenotypes in a mouse model of the disease.
Screening for a set of autosomal-dominant genetic conditions in a large, unselected cohort of individuals uncovers carriers who were missed by routine medical care, demonstrating the utility of broad genetic screening.
The combination of near to real-time whole-genome sequence analysis and epidemiology resulted in reliable assessments of the extent of SARS-CoV-2 transmission in the community, facilitating early decision-making to control local transmission of SARS-CoV-2 in the Netherlands.
A new study that models the COVID-19 epidemic in France suggests that although a second peak is likely unavoidable, maintaining social distancing and wearing masks when lockdown restrictions are lifted, as well as continuing to shelter vulnerable individuals, will reduce mortality and avoid overwhelming ICU facilities.
Pharmacological inhibition of GFRAL–RET signaling in preclinical tumor models supports the therapeutic potential for reversing GDF15-dependent cachexia in people with cancer.
In a cohort of recovered patients with COVID-19, virus spike-specific antibodies were consistently elicited, but neutralizing activity was highly variable and inversely correlated with the proportion of CCR6+CXCR3− spike-specific circulating follicular helper T cells.
By reprogramming innate immune cells to an immunosuppressive phenotype, myocardial infarction accelerates breast cancer progression in mice, and the clinical relevance of these findings was demonstrated in individuals with early-stage breast cancer who experienced cardiovascular events after cancer diagnosis.
A platform for rapid antibody discovery enabled the isolation of hundreds of human monoclonal antibodies against SARS-CoV-2 and the prioritization of potent antibody candidates for clinical trials in patients with COVID-19.
The combination of nearly real-time genome sequencing of SARS-CoV-2 in infected patients during the first 10 weeks of COVID-19 containment in Australia and epidemiological modeling is helping in understanding the dynamics of the COVID-19 pandemic and potentially guiding public health decisions.
Three separate rounds of serological surveys in the state of Rio Grande do Sul in Brazil from mid-April to mid-May 2020 show an increase in antibodies specific for SARS-CoV-2 over time.
The gut microbiomes of Irish Travellers, an ethnically distinct subpopulation of Ireland, have similarity to the microbiomes of non-industrialized populations, but externally imposed lifestyle changes may alter their microbiota, with potential health sequelae.
A machine-learning algorithm using electronic medical records and self-reported measures of stress at admission to the emergency department due to trauma can predict the risk and long-term trajectories of post-traumatic stress disorder in two independent cohorts.
Culturable Mycobacterium tuberculosis can be detected in cough aerosol from a high proportion of individuals infected with drug-resistant M. tuberculosis and correlate with a strong cough and low symptom score, indicating the need to focus on targeted interventions.
A phase 1 dose-escalating trial evaluating CD70 inhibition in combination with hypomethylating therapy results in the elimination of leukemia stem cells and achieves clinical activity in untreated patients with acute myeloid leukemia.
High levels of antibodies specific for the stalk region of influenza hemagglutinin protein are associated with expansion of mutant viruses in human volunteers, suggesting potential challenges for influenza vaccine efforts targeting the HA stalk.
Analysis of a large, single-center cohort of patients with cancer who were infected with COVID-19 uncovers factors associated with disease severity and interactions with anti-cancer therapies
A molecular analysis of tau from patients with sporadic Alzheimer’s disease reveals striking diversity in biochemical properties between patients, which influences seeding activity and correlates with the aggressiveness of the disease.
Single-cell transcriptomics analysis of malignant ascites samples from patients with high-grade serous ovarian cancer reveals inter- and intra-patient heterogeneity in malignant cells, cancer-associated fibroblasts and macrophages.
A systematic evaluation of the value of AI-based decision support in skin tumor diagnosis demonstrates the superiority of human–computer collaboration over each individual approach and supports the potential of automated approaches in diagnostic medicine.