News & Comment

Produce prescriptions improved fruit and vegetable intake, reduced food insecurity and improved biomarkers of cardiometabolic health, according to a large, retrospective, US-based study.

A monumental challenge to scientists due to its repetitive sequences, the human Y chromosome has now been fully sequenced — revealing new structures in regions critical for fertility.

A trial comparing long-term versus short-term antidepressant maintenance therapy fails to show a significant benefit of continued treatment.

Addition of the COX inhibitor piroxicam to levonorgestrel, a standard emergency contraceptive, increased its efficacy without increasing adverse events.

VX-548 selectively inhibits peripheral sodium channels to reduce acute pain, with potentially fewer safety concerns than for existing, nonselective blockers.

A first-in-human investigation of recombinant human antibody to ATTR shows its promise for the treatment of a rare cardiomyopathy.

Researchers have identified a naturally occurring, non–genetically modified symbiotic bacterium that inhabits the gut of mosquitoes and prevents Plasmodium transmission.

In a prospective study, artificial intelligence–assisted mammography screening had accuracy comparable to that of standard double reading — and substantially reduced radiologists’ workloads.

The addition of opioids to guideline-directed care showed no benefit over placebo in a randomized, controlled trial.

A systematic review uncovers almost no risk for sexual transmission of HIV at low levels of viral load.

A new framework systematically identifies patients with ataxia telangiectasia who are amenable to splice-switching ASO therapy — and could be applied to other rare diseases.

The monoclonal antibody donanemab, which clears amyloid plaques in the brain, slowed clinical progression of early symptomatic Alzheimer’s disease.

A large language model designed to give high-quality answers to medical questions outperforms previous iterations — but remains inferior to clinicians.

Early detection and a bundled treatment that combines recommended intervention strategies substantially reduces the risk of severe postpartum hemorrhage.

Ketamine was found to be noninferior to ECT in the treatment of nonpsychotic treatment-resistant major depression.

An RNA-based CAR T cell therapy demonstrated a reassuring safety profile and promising clinical activity in an early-phase trial.

A smartphone-based intervention package for community health workers led to an improvement in the treatment of common childhood illnesses when delivered at scale in Mozambique.

A study finds evidence of substantial international transmission of hepatitis C virus among men who have sex with men, particularly in Europe.

Endometriosis has long been understudied; now, research suggests that Fusobacterium infection may cause the condition — and that antibiotics could be used to treat it.

Researchers used base editing — a type of CRISPR technology — to create a cell-therapy product with potent activity in children with relapsed T-ALL.