News & Views

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  • New research can help policymakers make evidence-based decisions about the risks and benefits of in-person schooling; strategic use of the available data will be key to getting this right.

    • Elizabeth A. Stuart
    • David W. Dowdy
    News & Views
  • New studies highlight the immunological benefits of COVID-19 vaccine boosters, but questions remain over how to best make use of a limited global supply.

    • Jennifer A. Juno
    • Adam K. Wheatley
    News & Views
  • A phase 3 study with dalpiciclib reinforces the efficacy of CDK4/6 inhibitors in select patients with metastatic breast cancer; with several such inhibitors available, more evidence is needed to help guide treatment decisions.

    • Jose Manuel Perez-Garcia
    • Javier Cortes
    • Antonio Llombart-Cussac
    News & Views
  • New strategies based on nucleic acid technologies are being exploited to treat chronic hepatitis B—a pilot clinical study of antisense oligonucleotide treatment shows the potential promise of this approach.

    • T. Jake Liang
    News & Views
  • A phase 1 trial shows the feasibility of a novel approach combining a powered hip exoskeleton with a passive leg prosthesis to improve the energy efficiency of walking.

    • Varun Nalam
    • He (Helen) Huang
    News & Views
  • Machine learning applied to electronic medical records can be used to create personalized lab-test reference ranges and to quantify disease risk, which will pave the way for precision medicine in clinical care.

    • Alice Tang
    • Tomiko Oskotsky
    • Marina Sirota
    News & Views
  • Cytokine blockade can improve the survival rate of patients with COVID-19 who are at risk of respiratory failure, but timing and patient selection are key.

    • Randy Q. Cron
    • Roberto Caricchio
    • W. Winn Chatham
    News & Views
  • The first preliminary evidence that in vivo gene editing in a clinical setting is feasible with no early signs of severe adverse events comes from an ongoing clinical trial to treat transthyretin amyloidosis, a fatal monogenetic disease.

    • Hildegard Büning
    • Axel Schambach
    News & Views
  • A new trial suggests that pirfenidone, an approved treatment for idiopathic pulmonary fibrosis, may also reduce myocardial fibrosis in patients with heart failure who have a preserved left ventricular ejection fraction.

    • John G. F. Cleland
    • Pierpaolo Pellicori
    • Arantxa González
    News & Views
  • Heterologous dosing with the adenovirus-based ChAdOx1 (AstraZeneca) vaccine followed by an mRNA vaccine induced stronger immune responses than did the homologous ChAdOx1 vaccine series, according to recent immunogenicity studies.

    • Meagan E. Deming
    • Kirsten E. Lyke
    News & Views
  • A new study unpacks the complexities of COVID-19 vaccine hesitancy and acceptance across low-, middle- and high-income countries.

    • Shingai Machingaidze
    • Charles Shey Wiysonge
    News & Views
  • A yeast strain engineered to regulate levels of pathogenic metabolites in the gut provides protection against colitis in mouse models.

    • Mark Mimee
    • Cathryn R. Nagler
    News & Views