Letters

  • Letter |

    Neoadjuvant combination of immune checkpoint therapy in patients with cisplatin-ineligible bladder cancer achieves clinical efficacy and uncovers immune features as potential predictive biomarkers of treatment response.

    • Jianjun Gao
    • , Neema Navai
    • , Omar Alhalabi
    • , Arlene Siefker-Radtke
    • , Matthew T. Campbell
    • , Rebecca Slack Tidwell
    • , Charles C. Guo
    • , Ashish M. Kamat
    • , Surena F. Matin
    • , John C. Araujo
    • , Amishi Y. Shah
    • , Pavlos Msaouel
    • , Paul Corn
    • , Jianbo Wang
    • , John N. Papadopoulos
    • , Shalini S. Yadav
    • , Jorge M. Blando
    • , Fei Duan
    • , Sreyashi Basu
    • , Wenbin Liu
    • , Yu Shen
    • , Yuwei Zhang
    • , Marc Daniel Macaluso
    • , Ying Wang
    • , Jianfeng Chen
    • , Jianhua Zhang
    • , Andrew Futreal
    • , Colin Dinney
    • , James P. Allison
    • , Sangeeta Goswami
    •  & Padmanee Sharma
  • Letter |

    Neoadjuvant immunotherapy combination in the NABUCCO trial elicits high pathological complete response rates in patients with locoregionally advanced (stage III) urothelial cancer and provides molecular biomarkers of treatment efficacy.

    • Nick van Dijk
    • , Alberto Gil-Jimenez
    • , Karina Silina
    • , Kees Hendricksen
    • , Laura A. Smit
    • , Jeantine M. de Feijter
    • , Maurits L. van Montfoort
    • , Charlotte van Rooijen
    • , Dennis Peters
    • , Annegien Broeks
    • , Henk G. van der Poel
    • , Annemarie Bruining
    • , Yoni Lubeck
    • , Karolina Sikorska
    • , Thierry N. Boellaard
    • , Pia Kvistborg
    • , Daniel J. Vis
    • , Erik Hooijberg
    • , Ton N. Schumacher
    • , Maries van den Broek
    • , Lodewyk F. A. Wessels
    • , Christian U. Blank
    • , Bas W. van Rhijn
    •  & Michiel S. van der Heijden
  • Letter |

    A new bispecific CAR T cell product targeting the CD20 and CD19 antigens demonstrates an excellent safety profile and high clinical efficacy in patients with B cell non-Hodgkin lymphoma and chronic lymphocytic leukemia.

    • Nirav N. Shah
    • , Bryon D. Johnson
    • , Dina Schneider
    • , Fenlu Zhu
    • , Aniko Szabo
    • , Carolyn A. Keever-Taylor
    • , Winfried Krueger
    • , Andrew A. Worden
    • , Michael J. Kadan
    • , Sharon Yim
    • , Ashley Cunningham
    • , Mehdi Hamadani
    • , Timothy S. Fenske
    • , Boro Dropulić
    • , Rimas Orentas
    •  & Parameswaran Hari
  • Letter |

    Analysis of spatial heterogeneity of crowding in China and Italy, together with COVID-19 case data, show that cities with higher crowding have longer epidemics and higher attack rates after the first epidemic wave.

    • Benjamin Rader
    • , Samuel V. Scarpino
    • , Anjalika Nande
    • , Alison L. Hill
    • , Ben Adlam
    • , Robert C. Reiner
    • , David M. Pigott
    • , Bernardo Gutierrez
    • , Alexander E. Zarebski
    • , Munik Shrestha
    • , John S. Brownstein
    • , Marcia C. Castro
    • , Christopher Dye
    • , Huaiyu Tian
    • , Oliver G. Pybus
    •  & Moritz U. G. Kraemer
  • Letter |

    The randomized phase 2 trial S1320 comparing different dosing schedules of BRAF/MEK inhibitor combination in BRAF-mutated advanced melanoma shows intermittent therapy does not result in superior progression-free survival in patients.

    • Alain P. Algazi
    • , Megan Othus
    • , Adil I. Daud
    • , Roger S. Lo
    • , Janice M. Mehnert
    • , Thach-Giao Truong
    • , Robert Conry
    • , Kari Kendra
    • , Gary C. Doolittle
    • , Joseph I. Clark
    • , Michael J. Messino
    • , Dennis F. Moore Jr
    • , Christopher Lao
    • , Bryan A. Faller
    • , Rangaswamy Govindarajan
    • , Amy Harker-Murray
    • , Luke Dreisbach
    • , James Moon
    • , Kenneth F. Grossmann
    •  & Antoni Ribas
  • Letter |

    An observational study on a large cohort of patients with gastrointestinal cancer demonstrates the utility of ctDNA analysis for accelerating the enrollment of patients in clinical trials with no accompanying deterioration in treatment efficacy.

    • Yoshiaki Nakamura
    • , Hiroya Taniguchi
    • , Masafumi Ikeda
    • , Hideaki Bando
    • , Ken Kato
    • , Chigusa Morizane
    • , Taito Esaki
    • , Yoshito Komatsu
    • , Yasuyuki Kawamoto
    • , Naoki Takahashi
    • , Makoto Ueno
    • , Yoshinori Kagawa
    • , Tomohiro Nishina
    • , Takeshi Kato
    • , Yoshiyuki Yamamoto
    • , Junji Furuse
    • , Tadamichi Denda
    • , Hisato Kawakami
    • , Eiji Oki
    • , Takako Nakajima
    • , Naohiro Nishida
    • , Kensei Yamaguchi
    • , Hisateru Yasui
    • , Masahiro Goto
    • , Nobuhisa Matsuhashi
    • , Koushiro Ohtsubo
    • , Kentaro Yamazaki
    • , Akihito Tsuji
    • , Wataru Okamoto
    • , Katsuya Tsuchihara
    • , Takeharu Yamanaka
    • , Izumi Miki
    • , Yasutoshi Sakamoto
    • , Hiroko Ichiki
    • , Masayuki Hata
    • , Riu Yamashita
    • , Atsushi Ohtsu
    • , Justin I. Odegaard
    •  & Takayuki Yoshino
  • Letter |

    Clinical activity and biomarker analysis from the COMBI-i trial evaluating PD-1, BRAF and MEK inhibition in patients with metastatic melanoma demonstrate high response rates and uncover molecular correlates of long-term treatment benefit.

    • Reinhard Dummer
    • , Celeste Lebbé
    • , Victoria Atkinson
    • , Mario Mandalà
    • , Paul D. Nathan
    • , Ana Arance
    • , Erika Richtig
    • , Naoya Yamazaki
    • , Caroline Robert
    • , Dirk Schadendorf
    • , Hussein A. Tawbi
    • , Paolo A. Ascierto
    • , Antoni Ribas
    • , Keith T. Flaherty
    • , Neha Pakhle
    • , Catarina D. Campbell
    • , Daniel Gusenleitner
    • , Aisha Masood
    • , Jan C. Brase
    • , Eduard Gasal
    •  & Georgina V. Long
  • Letter |

    A global analysis generating high-resolution maps of travel time shows that 91.1% of the world’s population can reach a hospital or clinic within an hour if they have access to motorized transportation, but only 56.7% can do so by walking, highlighting additional inequities for underserved populations accessing healthcare.

    • D. J. Weiss
    • , A. Nelson
    • , C. A. Vargas-Ruiz
    • , K. Gligorić
    • , S. Bavadekar
    • , E. Gabrilovich
    • , A. Bertozzi-Villa
    • , J. Rozier
    • , H. S. Gibson
    • , T. Shekel
    • , C. Kamath
    • , A. Lieber
    • , K. Schulman
    • , Y. Shao
    • , V. Qarkaxhija
    • , A. K. Nandi
    • , S. H. Keddie
    • , S. Rumisha
    • , P. Amratia
    • , R. Arambepola
    • , E. G. Chestnutt
    • , J. J. Millar
    • , T. L. Symons
    • , E. Cameron
    • , K. E. Battle
    • , S. Bhatt
    •  & P. W. Gething
  • Letter |

    Cases linked to superspreading events are estimated to account for 80% of all local transmission of SARS-CoV-2 in Hong Kong in a study with implications for public health policies.

    • Dillon C. Adam
    • , Peng Wu
    • , Jessica Y. Wong
    • , Eric H. Y. Lau
    • , Tim K. Tsang
    • , Simon Cauchemez
    • , Gabriel M. Leung
    •  & Benjamin J. Cowling
  • Letter |

    Convalescent plasma for treatment of hospitalized patients with COVID-19 is associated with improved survival in a retrospective comparison with matched controls, supporting further study in randomized controlled trials.

    • Sean T. H. Liu
    • , Hung-Mo Lin
    • , Ian Baine
    • , Ania Wajnberg
    • , Jeffrey P. Gumprecht
    • , Farah Rahman
    • , Denise Rodriguez
    • , Pranai Tandon
    • , Adel Bassily-Marcus
    • , Jeffrey Bander
    • , Charles Sanky
    • , Amy Dupper
    • , Allen Zheng
    • , Freddy T. Nguyen
    • , Fatima Amanat
    • , Daniel Stadlbauer
    • , Deena R. Altman
    • , Benjamin K. Chen
    • , Florian Krammer
    • , Damodara Rao Mendu
    • , Adolfo Firpo-Betancourt
    • , Matthew A. Levin
    • , Emilia Bagiella
    • , Arturo Casadevall
    • , Carlos Cordon-Cardo
    • , Jeffrey S. Jhang
    • , Suzanne A. Arinsburg
    • , David L. Reich
    • , Judith A. Aberg
    •  & Nicole M. Bouvier
  • Letter |

    A GMP-compliant process for generating human iPSC-derived mesenchymal stromal cells tested in a phase 1 trial is safe and well tolerated in subjects with acute steroid-resistant graft versus host disease.

    • Adrian J. C. Bloor
    • , Amit Patel
    • , James E. Griffin
    • , Maria H. Gilleece
    • , Rohini Radia
    • , David T. Yeung
    • , Diana Drier
    • , Laurie S. Larson
    • , Gene I. Uenishi
    • , Derek Hei
    • , Kilian Kelly
    • , Igor Slukvin
    •  & John E. J. Rasko
  • Letter |

    The randomized-controlled trial ADVICE4U demonstrates non-inferiority of an automated AI-based decision support system compared with advice from expert physicians for optimal insulin dosing in youths with type 1 diabetes.

    • Revital Nimri
    • , Tadej Battelino
    • , Lori M. Laffel
    • , Robert H. Slover
    • , Desmond Schatz
    • , Stuart A. Weinzimer
    • , Klemen Dovc
    • , Thomas Danne
    • , Moshe Phillip
    • , Moshe Phillip
    • , Revital Nimri
    • , Shlomit Shalitin
    • , Rachel Bello
    • , Michal Nevo-Shenker
    • , Naama Fisch-Shvalb
    • , Galit Shiovitch-Mantzuri
    • , Orit Choresh
    • , Irit Drutz
    • , Yehiel Nava
    • , Alona Hemo
    • , Orna Hermon
    • , Rachel Nave
    • , Tadej Battelino
    • , Klemen Dovc
    • , Natasa Bratina
    • , Darja Smigoe-Schweiger
    • , Brigita Mali
    • , Ana Gianini
    • , Urska Sever
    • , Barbara Murn Berkopec
    • , Lori M. Laffel
    • , Michelle Katz
    • , Elvira Isganaitis
    • , Sanjeev Mehta
    • , Heidi Quinn
    • , Nisha Naik
    • , Zijing Guo
    • , Lisa Volkening
    • , Robert H. Slover
    • , Gregory Forlenza
    • , R. Paul Wadwa
    • , G. Todd Alonso
    • , Laurel Messer
    • , Lindsey Towers
    • , Katie Thivener
    • , Cari Berget
    • , Samantha Lange
    • , Emily Jost
    • , Maria Rossick-Solis
    • , Desmond Schatz
    • , Michael Haller
    • , Paul Hiers
    • , Laura Jacobsen
    • , Madison Smith
    • , Anastasia O’Neill
    • , Jennifer Hosford
    • , Alexis Perry
    • , Stuart A. Weinzimer
    • , Eda Cengiz
    • , Jennifer Sherr
    • , Kathryn Gibbons
    • , Lori Carria
    • , Melinda Zgorski
    • , Thomas Danne
    • , Torben Biester
    • , Olga Kordonouri
    • , Thekla von dem Berge
    • , Sarah Biester
    •  & Kerstin Remus
  • Letter |

    Polygenic risk scores can predict susceptibility to drug-induced liver injury in patients and can stratify cellular viability of iPSC-derived liver organoids and primary hepatocytes from multiple donors.

    • Masaru Koido
    • , Eri Kawakami
    • , Junko Fukumura
    • , Yui Noguchi
    • , Momoko Ohori
    • , Yasunori Nio
    • , Paola Nicoletti
    • , Guruprasad P. Aithal
    • , Ann K. Daly
    • , Paul B. Watkins
    • , Hisashi Anayama
    • , Yvonne Dragan
    • , Tadahiro Shinozawa
    •  & Takanori Takebe
  • Letter |

    Longitudinal molecular profiling of copy number alterations in patients with Barrett’s esophagus can identify patients at higher risk of developing esophageal cancer.

    • Sarah Killcoyne
    • , Eleanor Gregson
    • , David C. Wedge
    • , Dan J. Woodcock
    • , Matthew D. Eldridge
    • , Rachel de la Rue
    • , Ahmad Miremadi
    • , Sujath Abbas
    • , Adrienn Blasko
    • , Cassandra Kosmidou
    • , Wladyslaw Januszewicz
    • , Aikaterini Varanou Jenkins
    • , Moritz Gerstung
    •  & Rebecca C. Fitzgerald
  • Letter |

    In a first step toward developing autologous tissue grafts for the treatment of children with intestinal failure, patient-derived jejunal organoids seeded on scaffolds of decellularized human intestinal matrix formed grafts that had jejunal properties and formed luminal structures when transplanted into mice.

    • Laween Meran
    • , Isobel Massie
    • , Sara Campinoti
    • , Anne E. Weston
    • , Riana Gaifulina
    • , Lucinda Tullie
    • , Peter Faull
    • , Michael Orford
    • , Anna Kucharska
    • , Anna Baulies
    • , Laura Novellasdemunt
    • , Nikolaos Angelis
    • , Elizabeth Hirst
    • , Julia König
    • , Alfonso Maria Tedeschi
    • , Alessandro Filippo Pellegata
    • , Susanna Eli
    • , Ambrosius P. Snijders
    • , Lucy Collinson
    • , Nikhil Thapar
    • , Geraint M. H. Thomas
    • , Simon Eaton
    • , Paola Bonfanti
    • , Paolo De Coppi
    •  & Vivian S. W. Li
  • Letter
    | Open Access

    A single immunization with an adenovirus vector-based vaccine expressing a stabilized SARS-CoV-2 spike protein induces protection against SARS-CoV-2-induced weight loss, pneumonia and mortality in hamsters.

    • Lisa H. Tostanoski
    • , Frank Wegmann
    • , Amanda J. Martinot
    • , Carolin Loos
    • , Katherine McMahan
    • , Noe B. Mercado
    • , Jingyou Yu
    • , Chi N. Chan
    • , Stephen Bondoc
    • , Carly E. Starke
    • , Michael Nekorchuk
    • , Kathleen Busman-Sahay
    • , Cesar Piedra-Mora
    • , Linda M. Wrijil
    • , Sarah Ducat
    • , Jerome Custers
    • , Caroline Atyeo
    • , Stephanie Fischinger
    • , John S. Burke
    • , Jared Feldman
    • , Blake M. Hauser
    • , Timothy M. Caradonna
    • , Esther A. Bondzie
    • , Gabriel Dagotto
    • , Makda S. Gebre
    • , Catherine Jacob-Dolan
    • , Zijin Lin
    • , Shant H. Mahrokhian
    • , Felix Nampanya
    • , Ramya Nityanandam
    • , Laurent Pessaint
    • , Maciel Porto
    • , Vaneesha Ali
    • , Dalia Benetiene
    • , Komlan Tevi
    • , Hanne Andersen
    • , Mark G. Lewis
    • , Aaron G. Schmidt
    • , Douglas A. Lauffenburger
    • , Galit Alter
    • , Jacob D. Estes
    • , Hanneke Schuitemaker
    • , Roland Zahn
    •  & Dan H. Barouch
  • Letter |

    Characterization of a cohort of children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection provides insights into the immunopathogenic features of the disease.

    • Michael J. Carter
    • , Matthew Fish
    • , Aislinn Jennings
    • , Katie J. Doores
    • , Paul Wellman
    • , Jeffrey Seow
    • , Sam Acors
    • , Carl Graham
    • , Emma Timms
    • , Julia Kenny
    • , Stuart Neil
    • , Michael H. Malim
    • , Shane M. Tibby
    •  & Manu Shankar-Hari
  • Letter |

    Analysis of UK Biobank participants with wearable physical activity monitors demonstrates that high-volume physical activity and high-intensity activity are associated with reduced mortality.

    • Tessa Strain
    • , Katrien Wijndaele
    • , Paddy C. Dempsey
    • , Stephen J. Sharp
    • , Matthew Pearce
    • , Justin Jeon
    • , Tim Lindsay
    • , Nick Wareham
    •  & Søren Brage
  • Letter |

    A deep neural network applied to smartphone-based vascular imaging can detect diabetes, opening new possibilities for non-invasive diagnosis.

    • Robert Avram
    • , Jeffrey E. Olgin
    • , Peter Kuhar
    • , J. Weston Hughes
    • , Gregory M. Marcus
    • , Mark J. Pletcher
    • , Kirstin Aschbacher
    •  & Geoffrey H. Tison
  • Letter |

    Endogenous skeletal stem cells are recruited to form cartilage in mice when stimulated by microfracture surgery together with localized delivery of growth factors, pointing to a new approach for treating cartilage defects.

    • Matthew P. Murphy
    • , Lauren S. Koepke
    • , Michael T. Lopez
    • , Xinming Tong
    • , Thomas H. Ambrosi
    • , Gunsagar S. Gulati
    • , Owen Marecic
    • , Yuting Wang
    • , Ryan C. Ransom
    • , Malachia Y. Hoover
    • , Holly Steininger
    • , Liming Zhao
    • , Marcin P. Walkiewicz
    • , Natalina Quarto
    • , Benjamin Levi
    • , Derrick C. Wan
    • , Irving L. Weissman
    • , Stuart B. Goodman
    • , Fan Yang
    • , Michael T. Longaker
    •  & Charles K. F. Chan
  • Letter |

    In a cohort of nearly half a million births in Ontario, Canada, maternal cannabis use in pregnancy was associated with an increased incidence of autism spectrum disorder diagnosis in the offspring.

    • Daniel J. Corsi
    • , Jessy Donelle
    • , Ewa Sucha
    • , Steven Hawken
    • , Helen Hsu
    • , Darine El-Chaâr
    • , Lise Bisnaire
    • , Deshayne Fell
    • , Shi Wu Wen
    •  & Mark Walker
  • Letter |

    Whole-exome sequencing is not sensitive or specific enough to replace the gold standard of tandem mass spectrometry screening of rare inborn errors of metabolism, but can help to reduce false positives and facilitate the timely resolution of ambiguous cases.

    • Aashish N. Adhikari
    • , Renata C. Gallagher
    • , Yaqiong Wang
    • , Robert J. Currier
    • , George Amatuni
    • , Laia Bassaganyas
    • , Flavia Chen
    • , Kunal Kundu
    • , Mark Kvale
    • , Sean D. Mooney
    • , Robert L. Nussbaum
    • , Savanna S. Randi
    • , Jeremy Sanford
    • , Joseph T. Shieh
    • , Rajgopal Srinivasan
    • , Uma Sunderam
    • , Hao Tang
    • , Dedeepya Vaka
    • , Yangyun Zou
    • , Barbara A. Koenig
    • , Pui-Yan Kwok
    • , Neil Risch
    • , Jennifer M. Puck
    •  & Steven E. Brenner
  • Letter |

    Transmission dynamics models of COVID-19 and malaria reveal how different scenarios of COVID-19 spread and varying levels of interruption to antimalarial programs could result in increased deaths in sub-Saharan Africa.

    • Ellie Sherrard-Smith
    • , Alexandra B. Hogan
    • , Arran Hamlet
    • , Oliver J. Watson
    • , Charlie Whittaker
    • , Peter Winskill
    • , Fatima Ali
    • , Audu B. Mohammad
    • , Perpetua Uhomoibhi
    • , Ibrahim Maikore
    • , Nnenna Ogbulafor
    • , Jamilu Nikau
    • , Mara D. Kont
    • , Joseph D. Challenger
    • , Robert Verity
    • , Ben Lambert
    • , Matthew Cairns
    • , Bhargavi Rao
    • , Marc Baguelin
    • , Lilith K. Whittles
    • , John A. Lees
    • , Sangeeta Bhatia
    • , Edward S. Knock
    • , Lucy Okell
    • , Hannah C. Slater
    • , Azra C. Ghani
    • , Patrick G. T. Walker
    • , Okefu Oyale Okoko
    •  & Thomas S. Churcher
  • Letter |

    In a study of children with high genetic risk aged 2 years or older, a risk score integrating pancreatic islet autoantibodies, genetic factors and family history is highly predictive of type 1 diabetes in the subsequent 8 years.

    • Lauric A. Ferrat
    • , Kendra Vehik
    • , Seth A. Sharp
    • , Åke Lernmark
    • , Marian J. Rewers
    • , Jin-Xiong She
    • , Anette-G. Ziegler
    • , Jorma Toppari
    • , Beena Akolkar
    • , Jeffrey P. Krischer
    • , Michael N. Weedon
    • , Richard A. Oram
    • , William A. Hagopian
    • , Aaron Barbour
    • , Kimberly Bautista
    • , Judith Baxter
    • , Daniel Felipe-Morales
    • , Kimberly Driscoll
    • , Brigitte I. Frohnert
    • , Marisa Stahl
    • , Patricia Gesualdo
    • , Michelle Hoffman
    • , Rachel Karban
    • , Edwin Liu
    • , Jill Norris
    • , Stesha Peacock
    • , Hanan Shorrosh
    • , Andrea Steck
    • , Megan Stern
    • , Erica Villegas
    • , Kathleen Waugh
    • , Olli G. Simell
    • , Annika Adamsson
    • , Suvi Ahonen
    • , Mari Åkerlund
    • , Leena Hakola
    • , Anne Hekkala
    • , Henna Holappa
    • , Heikki Hyöty
    • , Anni Ikonen
    • , Jorma Ilonen
    • , Sinikka Jäminki
    • , Sanna Jokipuu
    • , Leena Karlsson
    • , Jukka Kero
    • , Miia Kähönen
    • , Mikael Knip
    • , Minna-Liisa Koivikko
    • , Merja Koskinen
    • , Mirva Koreasalo
    • , Kalle Kurppa
    • , Jarita Kytölä
    • , Tiina Latva-aho
    • , Katri Lindfors
    • , Maria Lönnrot
    • , Elina Mäntymäki
    • , Markus Mattila
    • , Maija Miettinen
    • , Katja Multasuo
    • , Teija Mykkänen
    • , Tiina Niininen
    • , Sari Niinistö
    • , Mia Nyblom
    • , Sami Oikarinen
    • , Paula Ollikainen
    • , Zhian Othmani
    • , Sirpa Pohjola
    • , Petra Rajala
    • , Jenna Rautanen
    • , Anne Riikonen
    • , Eija Riski
    • , Miia Pekkola
    • , Minna Romo
    • , Satu Ruohonen
    • , Satu Simell
    • , Maija Sjöberg
    • , Aino Stenius
    • , Päivi Tossavainen
    • , Mari Vähä-Mäkilä
    • , Sini Vainionpää
    • , Eeva Varjonen
    • , Riitta Veijola
    • , Irene Viinikangas
    • , Suvi M. Virtanen
    • , Desmond Schatz
    • , Diane Hopkins
    • , Leigh Steed
    • , Jennifer Bryant
    • , Katherine Silvis
    • , Michael Haller
    • , Melissa Gardiner
    • , Richard McIndoe
    • , Ashok Sharma
    • , Stephen W. Anderson
    • , Laura Jacobsen
    • , John Marks
    • , P. D. Towe
    • , Ezio Bonifacio
    • , Cigdem Gezginci
    • , Anja Heublein
    • , Eva Hohoff
    • , Sandra Hummel
    • , Annette Knopff
    • , Charlotte Koch
    • , Sibylle Koletzko
    • , Claudia Ramminger
    • , Roswith Roth
    • , Jennifer Schmidt
    • , Marlon Scholz
    • , Joanna Stock
    • , Katharina Warncke
    • , Lorena Wendel
    • , Christiane Winkler
    • , Daniel Agardh
    • , Carin Andrén Aronsson
    • , Maria Ask
    • , Rasmus Bennet
    • , Corrado Cilio
    • , Susanne Dahlberg
    • , Helene Engqvist
    • , Emelie Ericson-Hallström
    • , Annika Björne Fors
    • , Lina Fransson
    • , Thomas Gard
    • , Monika Hansen
    • , Hanna Jisser
    • , Fredrik Johansen
    • , Berglind Jonsdottir
    • , Helena Elding Larsson
    • , Marielle Lindström
    • , Markus Lundgren
    • , Marlena Maziarz
    • , Maria Månsson-Martinez
    • , Jessica Melin
    • , Zeliha Mestan
    • , Caroline Nilsson
    • , Karin Ottosson
    • , Kobra Rahmati
    • , Anita Ramelius
    • , Falastin Salami
    • , Anette Sjöberg
    • , Birgitta Sjöberg
    • , Carina Törn
    • , Åsa Wimar
    • , Michael Killian
    • , Claire Cowen Crouch
    • , Jennifer Skidmore
    • , Masumeh Chavoshi
    • , Arlene Meyer
    • , Jocelyn Meyer
    • , Denise Mulenga
    • , Nole Powell
    • , Jared Radtke
    • , Matei Romancik
    • , Shreya Roy
    • , Davey Schmitt
    • , Sarah Zink
    • , Dorothy Becker
    • , Margaret Franciscus
    • , MaryEllen Dalmagro-Elias Smith
    • , Ashi Daftary
    • , Mary Beth Klein
    • , Chrystal Yates
    • , Sarah Austin-Gonzalez
    • , Maryouri Avendano
    • , Sandra Baethke
    • , Brant Burkhardt
    • , Martha Butterworth
    • , Joanna Clasen
    • , David Cuthbertson
    • , Christopher Eberhard
    • , Steven Fiske
    • , Jennifer Garmeson
    • , Veena Gowda
    • , Kathleen Heyman
    • , Belinda Hsiao
    • , Christina Karges
    • , Francisco Perez Laras
    • , Qian Li
    • , Shu Liu
    • , Xiang Liu
    • , Kristian Lynch
    • , Colleen Maguire
    • , Jamie Malloy
    • , Cristina McCarthy
    • , Hemang Parikh
    • , Cassandra Remedios
    • , Chris Shaffer
    • , Laura Smith
    • , Susan Smith
    • , Noah Sulman
    • , Roy Tamura
    • , Dena Tewey
    • , Michael Toth
    • , Ulla Uusitalo
    • , Ponni Vijayakandipan
    • , Keith Wood
    • , Jimin Yang
    • , Liping Yu
    • , Dongmei Miao
    • , Polly Bingley
    • , Alistair Williams
    • , Kyla Chandler
    • , Ilana Kelland
    • , Yassin Ben Khoud
    • , Huma Zahid
    • , Matthew Randell
    • , Masumeh Chavoshi
    • , Jared Radtke
    • , Sarah Zink
    • , Sandra Ke
    • , Niveen Mulholland
    • , Stephen S. Rich
    • , Wei-Min Chen
    • , Suna Onengut-Gumuscu
    • , Emily Farber
    • , Rebecca Roche Pickin
    • , Jonathan Davis
    • , Jordan Davis
    • , Dan Gallo
    • , Jessica Bonnie
    • , Paul Campolieto
    • , Joseph F. Petrosino
    • , Nadim J. Ajami
    • , Richard E. Lloyd
    • , Matthew C. Ross
    • , Jacqueline L. O’Brien
    • , Diane S. Hutchinson
    • , Daniel P. Smith
    • , Matthew C. Wong
    • , Xianjun Tian
    • , Tulin Ayvaz
    • , Auriole Tamegnon
    • , Nguyen Truong
    • , Hannah Moreno
    • , Lauren Riley
    • , Eduardo Moreno
    • , Tonya Bauch
    • , Lenka Kusic
    • , Ginger Metcalf
    • , Donna Muzny
    • , Harshavardhan Doddapaneni
    • , Richard Gibbs
    • , Kasia Bourcier
    • , Thomas Briese
    • , Suzanne Bennett Johnson
    • , Eric Triplett
    • , Anette G. Ziegler
    • , Roy Tamura
    • , Jill Norris
    • , Suvi M. Virtanen
    • , Brigitte I. Frohnert
    • , Patricia Gesualdo
    • , Mirva Koreasalo
    • , Maija Miettinen
    • , Sari Niinistö
    • , Anne Riikonen
    • , Katherine Silvis
    • , Eva Hohoff
    • , Sandra Hummel
    • , Christiane Winkler
    • , Carin Andrén Aronsson
    • , Jennifer Skidmore
    • , MaryEllen Dalmagro-Elias Smith
    • , Martha Butterworth
    • , Qian Li
    • , Xiang Liu
    • , Roy Tamura
    • , Ulla Uusitalo
    • , Jimin Yang
    • , Stephen S. Rich
    • , Jill Norris
    • , Andrea Steck
    • , Jorma Ilonen
    • , Anette G. Ziegler
    • , Carina Törn
    • , Qian Li
    • , Xiang Liu
    • , Hemang Parikh
    • , Henry Erlich
    • , Wei-Min Chen
    • , Suna Onengut-Gumuscu
    • , Desmond Schatz
    • , Anette G. Ziegler
    • , Corrado Cilio
    • , Ezio Bonifacio
    • , Mikael Knip
    • , Desmond Schatz
    • , Brant Burkhardt
    • , Kristian Lynch
    • , Liping Yu
    • , Polly Bingley
    • , Kasia Bourcier
    • , Heikki Hyöty
    • , Eric Triplett
    • , Richard Lloyd
    • , Patricia Gesualdo
    • , Kathleen Waugh
    • , Maria Lönnrot
    • , Daniel Agardh
    • , Corrado Cilio
    • , Helena Elding Larsson
    • , Michael Killian
    • , Brant Burkhardt
    • , Kristian Lynch
    • , Thomas Briese
    • , Kathleen Waugh
    • , Desmond Schatz
    • , Michael Killian
    • , Suzanne Bennett Johnson
    • , Roswith Roth
    • , Judith Baxter
    • , Kimberly Driscoll
    • , Desmond Schatz
    • , Joanna Stock
    • , Steven Fiske
    • , Xiang Liu
    • , Kristian Lynch
    • , Laura Smith
    • , Judith Baxter
    • , Åke Lernmark
    • , Judith Baxter
    • , Michael Killian
    • , Kimberly Bautista
    • , Patricia Gesualdo
    • , Michelle Hoffman
    • , Rachel Karban
    • , Jill Norris
    • , Kathleen Waugh
    • , Annika Adamsson
    • , Miia Kähönen
    • , Tiina Niininen
    • , Aino Stenius
    • , Eeva Varjonen
    • , Diane Hopkins
    • , Leigh Steed
    • , Jennifer Bryant
    • , Melissa Gardiner
    • , John Marks
    • , Claudia Ramminger
    • , Joanna Stock
    • , Christiane Winkler
    • , Carin Andrén Aronsson
    • , Berglind Jonsdottir
    • , Jessica Melin
    • , Michael Killian
    • , Claire Cowen Crouch
    • , Denise Mulenga
    • , Cristina McCarthy
    • , Laura Smith
    • , Susan Smith
    • , Roy Tamura
    • , Suzanne Bennett Johnson
    • , Daniel Agardh
    • , Edwin Liu
    • , Sibylle Koletzko
    • , Kalle Kurppa
    • , Marisa Stahl
    • , Michelle Hoffman
    • , Kalle Kurppa
    • , Katri Lindfors
    • , Satu Simell
    • , Leigh Steed
    • , Carin Andrén Aronsson
    • , Michael Killian
    • , Roy Tamura
    • , Michael Haller
    • , Helena Elding Larsson
    • , Brigitte I. Frohnert
    • , Patricia Gesualdo
    • , Michelle Hoffman
    • , Andrea Steck
    • , Miia Kähönen
    • , Riitta Veijola
    • , Leigh Steed
    • , Laura Jacobsen
    • , John Marks
    • , Joanna Stock
    • , Katharina Warncke
    • , Markus Lundgren
    • , Åsa Wimar
    • , Claire Cowen Crouch
    • , Xiang Liu
    •  & Roy Tamura
  • Letter |

    Combining fine-scale social contact data with epidemic modeling reveals interactions among contact tracing, quarantine, testing and physical distancing for controlling COVID-19.

    • Josh A. Firth
    • , Joel Hellewell
    • , Petra Klepac
    • , Stephen Kissler
    • , Mark Jit
    • , Katherine E. Atkins
    • , Samuel Clifford
    • , C. Julian Villabona-Arenas
    • , Sophie R. Meakin
    • , Charlie Diamond
    • , Nikos I. Bosse
    • , James D. Munday
    • , Kiesha Prem
    • , Anna M. Foss
    • , Emily S. Nightingale
    • , Kevin van Zandvoort
    • , Nicholas G. Davies
    • , Hamish P. Gibbs
    • , Graham Medley
    • , Amy Gimma
    • , Stefan Flasche
    • , David Simons
    • , Megan Auzenbergs
    • , Timothy W. Russell
    • , Billy J. Quilty
    • , Eleanor M. Rees
    • , Quentin J. Leclerc
    • , W. John Edmunds
    • , Sebastian Funk
    • , Rein M. G. J. Houben
    • , Gwenan M. Knight
    • , Sam Abbott
    • , Fiona Yueqian Sun
    • , Rachel Lowe
    • , Damien C. Tully
    • , Simon R. Procter
    • , Christopher I. Jarvis
    • , Akira Endo
    • , Kathleen O’Reilly
    • , Jon C. Emery
    • , Thibaut Jombart
    • , Alicia Rosello
    • , Arminder K. Deol
    • , Matthew Quaife
    • , Stéphane Hué
    • , Yang Liu
    • , Rosalind M. Eggo
    • , Carl A. B. Pearson
    • , Adam J. Kucharski
    •  & Lewis G. Spurgin
  • Letter |

    A combination of clinical and molecular analyses supports an association between disorders of immune complement or coagulation with poor outcome in patients with SARS-CoV-2 infection.

    • Vijendra Ramlall
    • , Phyllis M. Thangaraj
    • , Cem Meydan
    • , Jonathan Foox
    • , Daniel Butler
    • , Jacob Kim
    • , Ben May
    • , Jessica K. De Freitas
    • , Benjamin S. Glicksberg
    • , Christopher E. Mason
    • , Nicholas P. Tatonetti
    •  & Sagi D. Shapira
  • Letter
    | Open Access

    Identification in Rwanda of mutations in Plasmodium falciparum capable of conferring in vitro resistance to artemisinin, an essential medicine for the treatment of malaria, underscore the crucial need for surveillance in Africa to safeguard efficacy of life-saving therapies.

    • Aline Uwimana
    • , Eric Legrand
    • , Barbara H. Stokes
    • , Jean-Louis Mangala Ndikumana
    • , Marian Warsame
    • , Noella Umulisa
    • , Daniel Ngamije
    • , Tharcisse Munyaneza
    • , Jean-Baptiste Mazarati
    • , Kaendi Munguti
    • , Pascal Campagne
    • , Alexis Criscuolo
    • , Frédéric Ariey
    • , Monique Murindahabi
    • , Pascal Ringwald
    • , David A. Fidock
    • , Aimable Mbituyumuremyi
    •  & Didier Menard
  • Letter |

    Clinical sequencing across a large prospective cohort of patients with myelodysplasic syndrome uncovers distinct associations between the mono- and biallelic states of TP53 and clinical presentation

    • Elsa Bernard
    • , Yasuhito Nannya
    • , Robert P. Hasserjian
    • , Sean M. Devlin
    • , Heinz Tuechler
    • , Juan S. Medina-Martinez
    • , Tetsuichi Yoshizato
    • , Yusuke Shiozawa
    • , Ryunosuke Saiki
    • , Luca Malcovati
    • , Max F. Levine
    • , Juan E. Arango
    • , Yangyu Zhou
    • , Francesc Solé
    • , Catherine A. Cargo
    • , Detlef Haase
    • , Maria Creignou
    • , Ulrich Germing
    • , Yanming Zhang
    • , Gunes Gundem
    • , Araxe Sarian
    • , Arjan A. van de Loosdrecht
    • , Martin Jädersten
    • , Magnus Tobiasson
    • , Olivier Kosmider
    • , Matilde Y. Follo
    • , Felicitas Thol
    • , Ronald F. Pinheiro
    • , Valeria Santini
    • , Ioannis Kotsianidis
    • , Jacqueline Boultwood
    • , Fabio P. S. Santos
    • , Julie Schanz
    • , Senji Kasahara
    • , Takayuki Ishikawa
    • , Hisashi Tsurumi
    • , Akifumi Takaori-Kondo
    • , Toru Kiguchi
    • , Chantana Polprasert
    • , John M. Bennett
    • , Virginia M. Klimek
    • , Michael R. Savona
    • , Monika Belickova
    • , Christina Ganster
    • , Laura Palomo
    • , Guillermo Sanz
    • , Lionel Ades
    • , Matteo Giovanni Della Porta
    • , Alexandra G. Smith
    • , Yesenia Werner
    • , Minal Patel
    • , Agnès Viale
    • , Katelynd Vanness
    • , Donna S. Neuberg
    • , Kristen E. Stevenson
    • , Kamal Menghrajani
    • , Kelly L. Bolton
    • , Pierre Fenaux
    • , Andrea Pellagatti
    • , Uwe Platzbecker
    • , Michael Heuser
    • , Peter Valent
    • , Shigeru Chiba
    • , Yasushi Miyazaki
    • , Carlo Finelli
    • , Maria Teresa Voso
    • , Lee-Yung Shih
    • , Michaela Fontenay
    • , Joop H. Jansen
    • , José Cervera
    • , Yoshiko Atsuta
    • , Norbert Gattermann
    • , Benjamin L. Ebert
    • , Rafael Bejar
    • , Peter L. Greenberg
    • , Mario Cazzola
    • , Eva Hellström-Lindberg
    • , Seishi Ogawa
    •  & Elli Papaemmanuil
  • Letter |

    An antisense oligonucleotide induces exon skipping in cell lines derived from patients with CLN3 Batten disease, and reduces lysosomal impairment and ameliorates neurological phenotypes in a mouse model of the disease.

    • Jessica L. Centa
    • , Francine M. Jodelka
    • , Anthony J. Hinrich
    • , Tyler B. Johnson
    • , Joseph Ochaba
    • , Michaela Jackson
    • , Dominik M. Duelli
    • , Jill M. Weimer
    • , Frank Rigo
    •  & Michelle L. Hastings
  • Letter |

    Screening for a set of autosomal-dominant genetic conditions in a large, unselected cohort of individuals uncovers carriers who were missed by routine medical care, demonstrating the utility of broad genetic screening.

    • J. J. Grzymski
    • , G. Elhanan
    • , J. A. Morales Rosado
    • , E. Smith
    • , K. A. Schlauch
    • , R. Read
    • , C. Rowan
    • , N. Slotnick
    • , S. Dabe
    • , W. J. Metcalf
    • , B. Lipp
    • , H. Reed
    • , L. Sharma
    • , E. Levin
    • , J. Kao
    • , M. Rashkin
    • , J. Bowes
    • , K. Dunaway
    • , A. Slonim
    • , N. Washington
    • , M. Ferber
    • , A. Bolze
    •  & J. T. Lu
  • Letter |

    The combination of near to real-time whole-genome sequence analysis and epidemiology resulted in reliable assessments of the extent of SARS-CoV-2 transmission in the community, facilitating early decision-making to control local transmission of SARS-CoV-2 in the Netherlands.

    • Bas B. Oude Munnink
    • , David F. Nieuwenhuijse
    • , Mart Stein
    • , Áine O’Toole
    • , Manon Haverkate
    • , Madelief Mollers
    • , Sandra K. Kamga
    • , Claudia Schapendonk
    • , Mark Pronk
    • , Pascal Lexmond
    • , Anne van der Linden
    • , Theo Bestebroer
    • , Irina Chestakova
    • , Ronald J. Overmars
    • , Stefan van Nieuwkoop
    • , Richard Molenkamp
    • , Annemiek A. van der Eijk
    • , Corine GeurtsvanKessel
    • , Harry Vennema
    • , Adam Meijer
    • , Andrew Rambaut
    • , Jaap van Dissel
    • , Reina S. Sikkema
    • , Aura Timen
    • , Marion Koopmans
    • , G. J. A. P. M. Oudehuis
    • , Janke Schinkel
    • , Jan Kluytmans
    • , Marjolein Kluytmans-van den Bergh
    • , Wouter van den Bijllaardt
    • , Robbert G. Berntvelsen
    • , Miranda M. L. van Rijen
    • , Peter Schneeberger
    • , Suzan Pas
    • , Bram M. Diederen
    • , Anneke M. C. Bergmans
    • , P. A. Verspui van der Eijk
    • , Jaco J. Verweij
    • , Anton G. N. Buiting
    • , Roel Streefkerk
    • , A. P. Aldenkamp
    • , P. de Man
    • , J. G. M. Koelemal
    • , D. Ong
    • , S. Paltansing
    • , N. Veassen
    • , Jacqueline Sleven
    • , Leendert Bakker
    • , Heinrich Brockhoff
    • , Ariene Rietveld
    • , Fred Slijkerman Megelink
    • , James Cohen Stuart
    • , Anne de Vries
    • , Wil van der Reijden
    • , A. Ros
    • , Esther Lodder
    • , Ellen Verspui-van der Eijk
    • , Inge Huijskens
    • , E. M. Kraan
    • , M. P. M. van der Linden
    • , S. B. Debast
    • , N. Al Naiemi
    • , A. C. M. Kroes
    • , Marjolein Damen
    • , Sander Dinant
    • , Sybren Lekkerkerk
    • , Oscar Pontesilli
    • , Pieter Smit
    • , Carla van Tienen
    • , P. C. R. Godschalk
    • , Jorien van Pelt
    • , Alewijn Ott
    • , Charlie van der Weijden
    • , Heiman Wertheim
    • , Janette Rahamat-Langendoen
    • , Johan Reimerink
    • , Rogier Bodewes
    • , Erwin Duizer
    • , Bas van der Veer
    • , Chantal Reusken
    • , Suzanne Lutgens
    • , Peter Schneeberger
    • , Mirjam Hermans
    • , P. Wever
    • , A. Leenders
    • , Henriette ter Waarbeek
    •  & Christian Hoebe
  • Letter |

    A new study that models the COVID-19 epidemic in France suggests that although a second peak is likely unavoidable, maintaining social distancing and wearing masks when lockdown restrictions are lifted, as well as continuing to shelter vulnerable individuals, will reduce mortality and avoid overwhelming ICU facilities.

    • Nicolas Hoertel
    • , Martin Blachier
    • , Carlos Blanco
    • , Mark Olfson
    • , Marc Massetti
    • , Marina Sánchez Rico
    • , Frédéric Limosin
    •  & Henri Leleu
  • Letter |

    Pharmacological inhibition of GFRAL–RET signaling in preclinical tumor models supports the therapeutic potential for reversing GDF15-dependent cachexia in people with cancer.

    • Rowena Suriben
    • , Michael Chen
    • , Jared Higbee
    • , Julie Oeffinger
    • , Richard Ventura
    • , Betty Li
    • , Kalyani Mondal
    • , Zhengyu Gao
    • , Dina Ayupova
    • , Pranali Taskar
    • , Diana Li
    • , Shelley R. Starck
    • , Hung-I Harry Chen
    • , Michele McEntee
    • , Subhash D. Katewa
    • , Van Phung
    • , Marilyn Wang
    • , Avantika Kekatpure
    • , Damodharan Lakshminarasimhan
    • , Andre White
    • , Andrea Olland
    • , Raj Haldankar
    • , Mark J. Solloway
    • , Jer-Yuan Hsu
    • , Yan Wang
    • , Jie Tang
    • , Darrin A. Lindhout
    •  & Bernard B. Allan
  • Letter |

    In a cohort of recovered patients with COVID-19, virus spike-specific antibodies were consistently elicited, but neutralizing activity was highly variable and inversely correlated with the proportion of CCR6+CXCR3 spike-specific circulating follicular helper T cells.

    • Jennifer A. Juno
    • , Hyon-Xhi Tan
    • , Wen Shi Lee
    • , Arnold Reynaldi
    • , Hannah G. Kelly
    • , Kathleen Wragg
    • , Robyn Esterbauer
    • , Helen E. Kent
    • , C. Jane Batten
    • , Francesca L. Mordant
    • , Nicholas A. Gherardin
    • , Phillip Pymm
    • , Melanie H. Dietrich
    • , Nichollas E. Scott
    • , Wai-Hong Tham
    • , Dale I. Godfrey
    • , Kanta Subbarao
    • , Miles P. Davenport
    • , Stephen J. Kent
    •  & Adam K. Wheatley
  • Letter |

    By reprogramming innate immune cells to an immunosuppressive phenotype, myocardial infarction accelerates breast cancer progression in mice, and the clinical relevance of these findings was demonstrated in individuals with early-stage breast cancer who experienced cardiovascular events after cancer diagnosis.

    • Graeme J. Koelwyn
    • , Alexandra A. C. Newman
    • , Milessa S. Afonso
    • , Coen van Solingen
    • , Emma M. Corr
    • , Emily J. Brown
    • , Kathleen B. Albers
    • , Naoko Yamaguchi
    • , Deven Narke
    • , Martin Schlegel
    • , Monika Sharma
    • , Lianne C. Shanley
    • , Tessa J. Barrett
    • , Karishma Rahman
    • , Valeria Mezzano
    • , Edward A. Fisher
    • , David S. Park
    • , Jonathan D. Newman
    • , Daniela F. Quail
    • , Erik R. Nelson
    • , Bette J. Caan
    • , Lee W. Jones
    •  & Kathryn J. Moore
  • Letter |

    A platform for rapid antibody discovery enabled the isolation of hundreds of human monoclonal antibodies against SARS-CoV-2 and the prioritization of potent antibody candidates for clinical trials in patients with COVID-19.

    • Seth J. Zost
    • , Pavlo Gilchuk
    • , Rita E. Chen
    • , James Brett Case
    • , Joseph X. Reidy
    • , Andrew Trivette
    • , Rachel S. Nargi
    • , Rachel E. Sutton
    • , Naveenchandra Suryadevara
    • , Elaine C. Chen
    • , Elad Binshtein
    • , Swathi Shrihari
    • , Mario Ostrowski
    • , Helen Y. Chu
    • , Jonathan E. Didier
    • , Keith W. MacRenaris
    • , Taylor Jones
    • , Samuel Day
    • , Luke Myers
    • , F. Eun-Hyung Lee
    • , Doan C. Nguyen
    • , Ignacio Sanz
    • , David R. Martinez
    • , Paul W. Rothlauf
    • , Louis-Marie Bloyet
    • , Sean P. J. Whelan
    • , Ralph S. Baric
    • , Larissa B. Thackray
    • , Michael S. Diamond
    • , Robert H. Carnahan
    •  & James E. Crowe Jr.
  • Letter |

    The combination of nearly real-time genome sequencing of SARS-CoV-2 in infected patients during the first 10 weeks of COVID-19 containment in Australia and epidemiological modeling is helping in understanding the dynamics of the COVID-19 pandemic and potentially guiding public health decisions.

    • Rebecca J. Rockett
    • , Alicia Arnott
    • , Connie Lam
    • , Rosemarie Sadsad
    • , Verlaine Timms
    • , Karen-Ann Gray
    • , John-Sebastian Eden
    • , Sheryl Chang
    • , Mailie Gall
    • , Jenny Draper
    • , Eby M. Sim
    • , Nathan L. Bachmann
    • , Ian Carter
    • , Kerri Basile
    • , Roy Byun
    • , Matthew V. O’Sullivan
    • , Sharon C-A Chen
    • , Susan Maddocks
    • , Tania C. Sorrell
    • , Dominic E. Dwyer
    • , Edward C. Holmes
    • , Jen Kok
    • , Mikhail Prokopenko
    •  & Vitali Sintchenko
  • Letter |

    Three separate rounds of serological surveys in the state of Rio Grande do Sul in Brazil from mid-April to mid-May 2020 show an increase in antibodies specific for SARS-CoV-2 over time.

    • Mariângela F. Silveira
    • , Aluísio J. D. Barros
    • , Bernardo L. Horta
    • , Lúcia C. Pellanda
    • , Gabriel D. Victora
    • , Odir A. Dellagostin
    • , Claudio J. Struchiner
    • , Marcelo N. Burattini
    • , Andréia R. M. Valim
    • , Evelise M. Berlezi
    • , Jeovany M. Mesa
    • , Maria Letícia R. Ikeda
    • , Marilia A. Mesenburg
    • , Marina Mantesso
    • , Marinel M. Dall’Agnol
    • , Raqueli A. Bittencourt
    • , Fernando P. Hartwig
    • , Ana M. B. Menezes
    • , Fernando C. Barros
    • , Pedro C. Hallal
    •  & Cesar G. Victora
  • Letter |

    The gut microbiomes of Irish Travellers, an ethnically distinct subpopulation of Ireland, have similarity to the microbiomes of non-industrialized populations, but externally imposed lifestyle changes may alter their microbiota, with potential health sequelae.

    • David M. Keohane
    • , Tarini Shankar Ghosh
    • , Ian B. Jeffery
    • , Michael G. Molloy
    • , Paul W. O’Toole
    •  & Fergus Shanahan
  • Letter |

    A machine-learning algorithm using electronic medical records and self-reported measures of stress at admission to the emergency department due to trauma can predict the risk and long-term trajectories of post-traumatic stress disorder in two independent cohorts.

    • Katharina Schultebraucks
    • , Arieh Y. Shalev
    • , Vasiliki Michopoulos
    • , Corita R. Grudzen
    • , Soo-Min Shin
    • , Jennifer S. Stevens
    • , Jessica L. Maples-Keller
    • , Tanja Jovanovic
    • , George A. Bonanno
    • , Barbara O. Rothbaum
    • , Charles R. Marmar
    • , Charles B. Nemeroff
    • , Kerry J. Ressler
    •  & Isaac R. Galatzer-Levy
  • Letter |

    Culturable Mycobacterium tuberculosis can be detected in cough aerosol from a high proportion of individuals infected with drug-resistant M. tuberculosis and correlate with a strong cough and low symptom score, indicating the need to focus on targeted interventions.

    • Grant Theron
    • , Jason Limberis
    • , Rouxjeane Venter
    • , Liezel Smith
    • , Elize Pietersen
    • , Aliasgar Esmail
    • , Greg Calligaro
    • , Julian te Riele
    • , Marianna de Kock
    • , Paul van Helden
    • , Tawanda Gumbo
    • , Taane G. Clark
    • , Kevin Fennelly
    • , Robin Warren
    •  & Keertan Dheda
  • Letter |

    A phase 1 dose-escalating trial evaluating CD70 inhibition in combination with hypomethylating therapy results in the elimination of leukemia stem cells and achieves clinical activity in untreated patients with acute myeloid leukemia.

    • Carsten Riether
    • , Thomas Pabst
    • , Sabine Höpner
    • , Ulrike Bacher
    • , Magdalena Hinterbrandner
    • , Yara Banz
    • , Rouven Müller
    • , Markus G. Manz
    • , Walid H. Gharib
    • , David Francisco
    • , Remy Bruggmann
    • , Luc van Rompaey
    • , Mahan Moshir
    • , Tim Delahaye
    • , Domenica Gandini
    • , Ellen Erzeel
    • , Anna Hultberg
    • , Samson Fung
    • , Hans de Haard
    • , Nicolas Leupin
    •  & Adrian F. Ochsenbein
  • Letter |

    High levels of antibodies specific for the stalk region of influenza hemagglutinin protein are associated with expansion of mutant viruses in human volunteers, suggesting potential challenges for influenza vaccine efforts targeting the HA stalk.

    • Jae-Keun Park
    • , Yongli Xiao
    • , Mitchell D. Ramuta
    • , Luz Angela Rosas
    • , Sharon Fong
    • , Alexis M. Matthews
    • , Ashley D. Freeman
    • , Monica A. Gouzoulis
    • , Natalia A. Batchenkova
    • , Xingdong Yang
    • , Kelsey Scherler
    • , Li Qi
    • , Susan Reed
    • , Rani Athota
    • , Lindsay Czajkowski
    • , Alison Han
    • , David M. Morens
    • , Kathie-Anne Walters
    • , Matthew J. Memoli
    • , John C. Kash
    •  & Jeffery K. Taubenberger
  • Letter |

    Analysis of a large, single-center cohort of patients with cancer who were infected with COVID-19 uncovers factors associated with disease severity and interactions with anti-cancer therapies

    • Elizabeth V. Robilotti
    • , N. Esther Babady
    • , Peter A. Mead
    • , Thierry Rolling
    • , Rocio Perez-Johnston
    • , Marilia Bernardes
    • , Yael Bogler
    • , Mario Caldararo
    • , Cesar J. Figueroa
    • , Michael S. Glickman
    • , Alexa Joanow
    • , Anna Kaltsas
    • , Yeon Joo Lee
    • , Anabella Lucca
    • , Amanda Mariano
    • , Sejal Morjaria
    • , Tamara Nawar
    • , Genovefa A. Papanicolaou
    • , Jacqueline Predmore
    • , Gil Redelman-Sidi
    • , Elizabeth Schmidt
    • , Susan K. Seo
    • , Kent Sepkowitz
    • , Monika K. Shah
    • , Jedd D. Wolchok
    • , Tobias M. Hohl
    • , Ying Taur
    •  & Mini Kamboj
  • Letter |

    Single-cell transcriptomics analysis of malignant ascites samples from patients with high-grade serous ovarian cancer reveals inter- and intra-patient heterogeneity in malignant cells, cancer-associated fibroblasts and macrophages.

    • Benjamin Izar
    • , Itay Tirosh
    • , Elizabeth H. Stover
    • , Isaac Wakiro
    • , Michael S. Cuoco
    • , Idan Alter
    • , Christopher Rodman
    • , Rachel Leeson
    • , Mei-Ju Su
    • , Parin Shah
    • , Marcin Iwanicki
    • , Sarah R. Walker
    • , Abhay Kanodia
    • , Johannes C. Melms
    • , Shaolin Mei
    • , Jia-Ren Lin
    • , Caroline B. M. Porter
    • , Michal Slyper
    • , Julia Waldman
    • , Livnat Jerby-Arnon
    • , Orr Ashenberg
    • , Titus J. Brinker
    • , Caitlin Mills
    • , Meri Rogava
    • , Sébastien Vigneau
    • , Peter K. Sorger
    • , Levi A. Garraway
    • , Panagiotis A. Konstantinopoulos
    • , Joyce F. Liu
    • , Ursula Matulonis
    • , Bruce E. Johnson
    • , Orit Rozenblatt-Rosen
    • , Asaf Rotem
    •  & Aviv Regev
  • Letter |

    A molecular analysis of tau from patients with sporadic Alzheimer’s disease reveals striking diversity in biochemical properties between patients, which influences seeding activity and correlates with the aggressiveness of the disease.

    • Simon Dujardin
    • , Caitlin Commins
    • , Aurelien Lathuiliere
    • , Pieter Beerepoot
    • , Analiese R. Fernandes
    • , Tarun V. Kamath
    • , Mark B. De Los Santos
    • , Naomi Klickstein
    • , Diana L. Corjuc
    • , Bianca T. Corjuc
    • , Patrick M. Dooley
    • , Arthur Viode
    • , Derek H. Oakley
    • , Benjamin D. Moore
    • , Kristina Mullin
    • , Dinorah Jean-Gilles
    • , Ryan Clark
    • , Kevin Atchison
    • , Renee Moore
    • , Lori B. Chibnik
    • , Rudolph E. Tanzi
    • , Matthew P. Frosch
    • , Alberto Serrano-Pozo
    • , Fiona Elwood
    • , Judith A. Steen
    • , Matthew E. Kennedy
    •  & Bradley T. Hyman
  • Letter |

    A systematic evaluation of the value of AI-based decision support in skin tumor diagnosis demonstrates the superiority of human–computer collaboration over each individual approach and supports the potential of automated approaches in diagnostic medicine.

    • Philipp Tschandl
    • , Christoph Rinner
    • , Zoe Apalla
    • , Giuseppe Argenziano
    • , Noel Codella
    • , Allan Halpern
    • , Monika Janda
    • , Aimilios Lallas
    • , Caterina Longo
    • , Josep Malvehy
    • , John Paoli
    • , Susana Puig
    • , Cliff Rosendahl
    • , H. Peter Soyer
    • , Iris Zalaudek
    •  & Harald Kittler
  • Letter |

    A cohort of asymptomatic patients infected with SARS-CoV-2 had significantly lower levels of virus-specific IgG antibodies compared to a cohort of age- and sex-matched symptomatic infected patients.

    • Quan-Xin Long
    • , Xiao-Jun Tang
    • , Qiu-Lin Shi
    • , Qin Li
    • , Hai-Jun Deng
    • , Jun Yuan
    • , Jie-Li Hu
    • , Wei Xu
    • , Yong Zhang
    • , Fa-Jin Lv
    • , Kun Su
    • , Fan Zhang
    • , Jiang Gong
    • , Bo Wu
    • , Xia-Mao Liu
    • , Jin-Jing Li
    • , Jing-Fu Qiu
    • , Juan Chen
    •  & Ai-Long Huang
  • Letter |

    A new epidemiological study shows reduced susceptibility to SARS-CoV-2 and decreased risk of developing severe symptoms in people aged younger than 20 years, suggesting that children have limited contribution to spread of COVID-19.

    • Nicholas G. Davies
    • , Petra Klepac
    • , Yang Liu
    • , Kiesha Prem
    • , Mark Jit
    • , Carl A. B. Pearson
    • , Billy J. Quilty
    • , Adam J. Kucharski
    • , Hamish Gibbs
    • , Samuel Clifford
    • , Amy Gimma
    • , Kevin van Zandvoort
    • , James D. Munday
    • , Charlie Diamond
    • , W. John Edmunds
    • , Rein M. G. J. Houben
    • , Joel Hellewell
    • , Timothy W. Russell
    • , Sam Abbott
    • , Sebastian Funk
    • , Nikos I. Bosse
    • , Yueqian Fiona Sun
    • , Stefan Flasche
    • , Alicia Rosello
    • , Christopher I. Jarvis
    •  & Rosalind M. Eggo
  • Letter |

    Projection of the number of COVID-19 cases and the associated burden on healthcare resources using a modified SEIR model reveals that rural regions in the United States are at risk of higher per capita case burdens, which could lead to health systems being overwhelmed in these areas.

    • Ian F. Miller
    • , Alexander D. Becker
    • , Bryan T. Grenfell
    •  & C. Jessica E. Metcalf