Articles

  • Article |

    On the basis of the personalized data of over 300,000 individuals with urinary tract infections, a machine-learning algorithm can help select an antibiotic for treatment of a urinary tract infection to which the infecting pathogen is not already resistant.

    • Idan Yelin
    • , Olga Snitser
    • , Gal Novich
    • , Rachel Katz
    • , Ofir Tal
    • , Miriam Parizade
    • , Gabriel Chodick
    • , Gideon Koren
    • , Varda Shalev
    •  & Roy Kishony
  • Article |

    Zinc finger protein transcription factors are developed for the selective silencing of the mutant huntingtin gene in human neurons in vitro and multiple animal models of Huntington’s disease in vivo while preserving expression of the wild-type allele.

    • Bryan Zeitler
    • , Steven Froelich
    • , Kimberly Marlen
    • , David A Shivak
    • , Qi Yu
    • , Davis Li
    • , Jocelynn R Pearl
    • , Jeffrey C Miller
    • , Lei Zhang
    • , David E Paschon
    • , Sarah J Hinkley
    • , Irina Ankoudinova
    • , Stephen Lam
    • , Dmitry Guschin
    • , Lexi Kopan
    • , Jennifer M Cherone
    • , Hoang-Oanh B Nguyen
    • , Guijuan Qiao
    • , Yasaman Ataei
    • , Matthew C Mendel
    • , Rainier Amora
    • , Richard Surosky
    • , Josee Laganiere
    • , B Joseph Vu
    • , Anand Narayanan
    • , Yalda Sedaghat
    • , Karsten Tillack
    • , Christina Thiede
    • , Annette Gärtner
    • , Seung Kwak
    • , Jonathan Bard
    • , Ladislav Mrzljak
    • , Larry Park
    • , Taneli Heikkinen
    • , Kimmo K Lehtimäki
    • , Marie M Svedberg
    • , Jenny Häggkvist
    • , Lenke Tari
    • , Miklós Tóth
    • , Andrea Varrone
    • , Christer Halldin
    • , Andrea E Kudwa
    • , Sylvie Ramboz
    • , Michelle Day
    • , Jyothisri Kondapalli
    • , D James Surmeier
    • , Fyodor D Urnov
    • , Philip D Gregory
    • , Edward J Rebar
    • , Ignacio Muñoz-Sanjuán
    •  & H Steve Zhang
  • Article |

    Bacteriotherapy using gut-derived bacteria from healthy human infants, but not infants with food allergies, suppresses food allergy symptoms in mice via induction of Foxp3 + Rorγt + regulatory T cells

    • Azza Abdel-Gadir
    • , Emmanuel Stephen-Victor
    • , Georg K. Gerber
    • , Magali Noval Rivas
    • , Sen Wang
    • , Hani Harb
    • , Leighanne Wang
    • , Ning Li
    • , Elena Crestani
    • , Sara Spielman
    • , William Secor
    • , Heather Biehl
    • , Nicholas Dibendetto
    • , Xiaoxi Dong
    • , Dale T. Umetsu
    • , Lynn Bry
    • , Rima Rachid
    •  & Talal A. Chatila
  • Article |

    Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4+ T cells, in asthmatic lungs

    • Felipe A. Vieira Braga
    • , Gozde Kar
    • , Marijn Berg
    • , Orestes A. Carpaij
    • , Krzysztof Polanski
    • , Lukas M. Simon
    • , Sharon Brouwer
    • , Tomás Gomes
    • , Laura Hesse
    • , Jian Jiang
    • , Eirini S. Fasouli
    • , Mirjana Efremova
    • , Roser Vento-Tormo
    • , Carlos Talavera-López
    • , Marnix R. Jonker
    • , Karen Affleck
    • , Subarna Palit
    • , Paulina M. Strzelecka
    • , Helen V. Firth
    • , Krishnaa T. Mahbubani
    • , Ana Cvejic
    • , Kerstin B. Meyer
    • , Kourosh Saeb-Parsy
    • , Marjan Luinge
    • , Corry-Anke Brandsma
    • , Wim Timens
    • , Ilias Angelidis
    • , Maximilian Strunz
    • , Gerard H. Koppelman
    • , Antoon J. van Oosterhout
    • , Herbert B. Schiller
    • , Fabian J. Theis
    • , Maarten van den Berge
    • , Martijn C. Nawijn
    •  & Sarah A. Teichmann
  • Article | | open

    As part of the second phase of Human Microbiome Project, the Multi-Omic Microbiome Study: Pregnancy Initiative presents a community resource to help better understand how microbiome and host profiles change throughout pregnancy as well as to identify new opportunities for assessment of the risk of preterm birth.

    • Jennifer M. Fettweis
    • , Myrna G. Serrano
    • , J. Paul Brooks
    • , David J. Edwards
    • , Philippe H. Girerd
    • , Hardik I. Parikh
    • , Bernice Huang
    • , Tom J. Arodz
    • , Laahirie Edupuganti
    • , Abigail L. Glascock
    • , Jie Xu
    • , Nicole R. Jimenez
    • , Stephany C. Vivadelli
    • , Stephen S. Fong
    • , Nihar U. Sheth
    • , Sophonie Jean
    • , Vladimir Lee
    • , Yahya A. Bokhari
    • , Ana M. Lara
    • , Shreni D. Mistry
    • , Robert A. Duckworth III
    • , Steven P. Bradley
    • , Vishal N. Koparde
    • , X. Valentine Orenda
    • , Sarah H. Milton
    • , Sarah K. Rozycki
    • , Andrey V. Matveyev
    • , Michelle L. Wright
    • , Snehalata V. Huzurbazar
    • , Eugenie M. Jackson
    • , Ekaterina Smirnova
    • , Jonas Korlach
    • , Yu-Chih Tsai
    • , Molly R. Dickinson
    • , Jamie L. Brooks
    • , Jennifer I. Drake
    • , Donald O. Chaffin
    • , Amber L. Sexton
    • , Michael G. Gravett
    • , Craig E. Rubens
    • , N. Romesh Wijesooriya
    • , Karen D. Hendricks-Muñoz
    • , Kimberly K. Jefferson
    • , Jerome F. Strauss III
    •  & Gregory A. Buck
  • Article |

    Ancestry and socioeconomic factors influence predictable changes in the vaginal microbiome that occur early in pregnancy in women who experience normal term birth.

    • Myrna G. Serrano
    • , Hardik I. Parikh
    • , J. Paul Brooks
    • , David J. Edwards
    • , Tom J. Arodz
    • , Laahirie Edupuganti
    • , Bernice Huang
    • , Philippe H. Girerd
    • , Yahya A. Bokhari
    • , Steven P. Bradley
    • , Jamie L. Brooks
    • , Molly R. Dickinson
    • , Jennifer I. Drake
    • , Robert A. Duckworth III
    • , Stephen S. Fong
    • , Abigail L. Glascock
    • , Sophonie Jean
    • , Nicole R. Jimenez
    • , Joseph Khoury
    • , Vishal N. Koparde
    • , Ana M. Lara
    • , Vladimir Lee
    • , Andrey V. Matveyev
    • , Sarah H. Milton
    • , Shreni D. Mistry
    • , Sarah K. Rozycki
    • , Nihar U. Sheth
    • , Ekaterina Smirnova
    • , Stephany C. Vivadelli
    • , N. Romesh Wijesooriya
    • , Jie Xu
    • , Ping Xu
    • , Donald O. Chaffin
    • , Amber L. Sexton
    • , Michael G. Gravett
    • , Craig E. Rubens
    • , Karen D. Hendricks-Muñoz
    • , Kimberly K. Jefferson
    • , Jerome F. Strauss III
    • , Jennifer M. Fettweis
    •  & Gregory A. Buck
  • Article | | open

    New immune biomarkers of exposure to tuberculosis may require a rethink of evidence of Mycobacterium tuberculosis infection and control.

    • Lenette L. Lu
    • , Malisa T. Smith
    • , Krystle K. Q. Yu
    • , Corinne Luedemann
    • , Todd J. Suscovich
    • , Patricia S. Grace
    • , Adam Cain
    • , Wen Han Yu
    • , Tanya R. McKitrick
    • , Douglas Lauffenburger
    • , Richard D. Cummings
    • , Harriet Mayanja-Kizza
    • , Thomas R. Hawn
    • , W. Henry Boom
    • , Catherine M. Stein
    • , Sarah M. Fortune
    • , Chetan Seshadri
    •  & Galit Alter
  • Article |

    The detrimental effects of aged blood on cognition and nervous system function in mice can be combatted by targeting brain endothelial cell dysfunction via inhibition of aberrant VCAM1 signaling at the blood–brain barrier.

    • Hanadie Yousef
    • , Cathrin J. Czupalla
    • , Davis Lee
    • , Michelle B. Chen
    • , Ashley N. Burke
    • , Kristy A. Zera
    • , Judith Zandstra
    • , Elisabeth Berber
    • , Benoit Lehallier
    • , Vidhu Mathur
    • , Ramesh V. Nair
    • , Liana N. Bonanno
    • , Andrew C. Yang
    • , Todd Peterson
    • , Husein Hadeiba
    • , Taylor Merkel
    • , Jakob Körbelin
    • , Markus Schwaninger
    • , Marion S. Buckwalter
    • , Stephen R. Quake
    • , Eugene C. Butcher
    •  & Tony Wyss-Coray
  • Article |

    Personalized omics profiling can lead to actionable health discoveries and stimulate lifestyle changes.

    • Sophia Miryam Schüssler-Fiorenza Rose
    • , Kévin Contrepois
    • , Kegan J. Moneghetti
    • , Wenyu Zhou
    • , Tejaswini Mishra
    • , Samson Mataraso
    • , Orit Dagan-Rosenfeld
    • , Ariel B. Ganz
    • , Jessilyn Dunn
    • , Daniel Hornburg
    • , Shannon Rego
    • , Dalia Perelman
    • , Sara Ahadi
    • , M. Reza Sailani
    • , Yanjiao Zhou
    • , Shana R. Leopold
    • , Jieming Chen
    • , Melanie Ashland
    • , Jeffrey W. Christle
    • , Monika Avina
    • , Patricia Limcaoco
    • , Camilo Ruiz
    • , Marilyn Tan
    • , Atul J. Butte
    • , George M. Weinstock
    • , George M. Slavich
    • , Erica Sodergren
    • , Tracey L. McLaughlin
    • , Francois Haddad
    •  & Michael P. Snyder
  • Article |

    Elevated activity of the methionine cycle is essential for cancer stem cell tumorigenesis and represents a therapeutic vulnerability.

    • Zhenxun Wang
    • , Lian Yee Yip
    • , Jia Hui Jane Lee
    • , Zhengwei Wu
    • , Hui Yi Chew
    • , Pooi Kiat William Chong
    • , Chin Chye Teo
    • , Heather Yin-Kuan Ang
    • , Kai Lay Esther Peh
    • , Ju Yuan
    • , Siming Ma
    • , Li Shi Kimberly Choo
    • , Nurhidayah Basri
    • , Xia Jiang
    • , Qiang Yu
    • , Axel M. Hillmer
    • , Wan Teck Lim
    • , Tony Kiat Hon Lim
    • , Angela Takano
    • , Eng Huat Tan
    • , Daniel Shao Weng Tan
    • , Ying Swan Ho
    • , Bing Lim
    •  & Wai Leong Tam
  • Article |

    A robust signature of circulating inflammatory proteins is causally associated with 10-year risk of progression to end-stage renal disease in diabetic patients

    • Monika A. Niewczas
    • , Meda E. Pavkov
    • , Jan Skupien
    • , Adam Smiles
    • , Zaipul I. Md Dom
    • , Jonathan M. Wilson
    • , Jihwan Park
    • , Viji Nair
    • , Andrew Schlafly
    • , Pierre-Jean Saulnier
    • , Eiichiro Satake
    • , Christopher A. Simeone
    • , Hetal Shah
    • , Chengxiang Qiu
    • , Helen C. Looker
    • , Paolo Fiorina
    • , Carl F. Ware
    • , Jennifer K. Sun
    • , Alessandro Doria
    • , Matthias Kretzler
    • , Katalin Susztak
    • , Kevin L. Duffin
    • , Robert G. Nelson
    •  & Andrzej S. Krolewski
  • Article |

    In situ vaccine recruits and activates cross-presenting dendritic cells and augments PD1 blockade efficacy in patients with indolent non-Hodgkin’s lymphoma.

    • Linda Hammerich
    • , Thomas U. Marron
    • , Ranjan Upadhyay
    • , Judit Svensson-Arvelund
    • , Maxime Dhainaut
    • , Shafinaz Hussein
    • , Yougen Zhan
    • , Dana Ostrowski
    • , Michael Yellin
    • , Henry Marsh
    • , Andres M. Salazar
    • , Adeeb H. Rahman
    • , Brian D. Brown
    • , Miriam Merad
    •  & Joshua D. Brody
  • Article |

    Blockade of intrahepatic accumulation and function of platelets represents a potential approach to treat non-alcoholic steatohepatitis (NASH) and prevent subsequent progression to hepatocellular carcinoma

    • Mohsen Malehmir
    • , Dominik Pfister
    • , Suchira Gallage
    • , Marta Szydlowska
    • , Donato Inverso
    • , Elena Kotsiliti
    • , Valentina Leone
    • , Moritz Peiseler
    • , Bas G. J. Surewaard
    • , Dominik Rath
    • , Adnan Ali
    • , Monika Julia Wolf
    • , Hannah Drescher
    • , Marc E. Healy
    • , Daniel Dauch
    • , Daniela Kroy
    • , Oliver Krenkel
    • , Marlene Kohlhepp
    • , Thomas Engleitner
    • , Alexander Olkus
    • , Tjeerd Sijmonsma
    • , Julia Volz
    • , Carsten Deppermann
    • , David Stegner
    • , Patrick Helbling
    • , César Nombela-Arrieta
    • , Anahita Rafiei
    • , Martina Hinterleitner
    • , Marcel Rall
    • , Florian Baku
    • , Oliver Borst
    • , Caroline L. Wilson
    • , Jack Leslie
    • , Tracy O’Connor
    • , Christopher J. Weston
    • , David H. Adams
    • , Lozan Sheriff
    • , Ana Teijeiro
    • , Marco Prinz
    • , Ruzhica Bogeska
    • , Natasha Anstee
    • , Malte N. Bongers
    • , Mike Notohamiprodjo
    • , Tobias Geisler
    • , Dominic J. Withers
    • , Jerry Ware
    • , Derek A. Mann
    • , Hellmut G. Augustin
    • , Alexandros Vegiopoulos
    • , Michael D. Milsom
    • , Adam J. Rose
    • , Patricia F. Lalor
    • , Josep M. Llovet
    • , Roser Pinyol
    • , Frank Tacke
    • , Roland Rad
    • , Matthias Matter
    • , Nabil Djouder
    • , Paul Kubes
    • , Percy A. Knolle
    • , Kristian Unger
    • , Lars Zender
    • , Bernhard Nieswandt
    • , Meinrad Gawaz
    • , Achim Weber
    •  & Mathias Heikenwalder
  • Article |

    Cross-study analysis defines fecal microbial species associated with colorectal cancer.

    • Jakob Wirbel
    • , Paul Theodor Pyl
    • , Ece Kartal
    • , Konrad Zych
    • , Alireza Kashani
    • , Alessio Milanese
    • , Jonas S. Fleck
    • , Anita Y. Voigt
    • , Albert Palleja
    • , Ruby Ponnudurai
    • , Shinichi Sunagawa
    • , Luis Pedro Coelho
    • , Petra Schrotz-King
    • , Emily Vogtmann
    • , Nina Habermann
    • , Emma Niméus
    • , Andrew M. Thomas
    • , Paolo Manghi
    • , Sara Gandini
    • , Davide Serrano
    • , Sayaka Mizutani
    • , Hirotsugu Shiroma
    • , Satoshi Shiba
    • , Tatsuhiro Shibata
    • , Shinichi Yachida
    • , Takuji Yamada
    • , Levi Waldron
    • , Alessio Naccarati
    • , Nicola Segata
    • , Rashmi Sinha
    • , Cornelia M. Ulrich
    • , Hermann Brenner
    • , Manimozhiyan Arumugam
    • , Peer Bork
    •  & Georg Zeller
  • Article |

    A small molecule that restores the integrity of the intestinal barrier provides a novel therapeutic strategy for inflammatory bowel diseases.

    • W. Vallen Graham
    • , Weiqi He
    • , Amanda M. Marchiando
    • , Juanmin Zha
    • , Gurminder Singh
    • , Hua-Shan Li
    • , Amlan Biswas
    • , Ma. Lora Drizella M. Ong
    • , Zhi-Hui Jiang
    • , Wangsun Choi
    • , Harmon Zuccola
    • , Yitang Wang
    • , James Griffith
    • , Jingshing Wu
    • , Harry J. Rosenberg
    • , Yingmin Wang
    • , Scott B. Snapper
    • , David Ostrov
    • , Stephen C. Meredith
    • , Lawrence W. Miller
    •  & Jerrold R. Turner
  • Article |

    Multicohort analysis identifies microbial signatures of colorectal cancer in fecal microbiomes.

    • Andrew Maltez Thomas
    • , Paolo Manghi
    • , Francesco Asnicar
    • , Edoardo Pasolli
    • , Federica Armanini
    • , Moreno Zolfo
    • , Francesco Beghini
    • , Serena Manara
    • , Nicolai Karcher
    • , Chiara Pozzi
    • , Sara Gandini
    • , Davide Serrano
    • , Sonia Tarallo
    • , Antonio Francavilla
    • , Gaetano Gallo
    • , Mario Trompetto
    • , Giulio Ferrero
    • , Sayaka Mizutani
    • , Hirotsugu Shiroma
    • , Satoshi Shiba
    • , Tatsuhiro Shibata
    • , Shinichi Yachida
    • , Takuji Yamada
    • , Jakob Wirbel
    • , Petra Schrotz-King
    • , Cornelia M. Ulrich
    • , Hermann Brenner
    • , Manimozhiyan Arumugam
    • , Peer Bork
    • , Georg Zeller
    • , Francesca Cordero
    • , Emmanuel Dias-Neto
    • , João Carlos Setubal
    • , Adrian Tett
    • , Barbara Pardini
    • , Maria Rescigno
    • , Levi Waldron
    • , Alessio Naccarati
    •  & Nicola Segata
  • Article |

    Defects in the regulation of leptin gene expression can lead to a hypoleptinemic, leptin-responsive form of obesity.

    • Olof S. Dallner
    • , Jill M. Marinis
    • , Yi-Hsueh. Lu
    • , Kivanc Birsoy
    • , Emory Werner
    • , Gulya Fayzikhodjaeva
    • , Brian D. Dill
    • , Henrik Molina
    • , Arden Moscati
    • , Zoltán Kutalik
    • , Pedro Marques-Vidal
    • , Tuomas O. Kilpeläinen
    • , Niels Grarup
    • , Allan Linneberg
    • , Yinxin Zhang
    • , Roger Vaughan
    • , Ruth J. F. Loos
    • , Mitchell A. Lazar
    •  & Jeffrey M. Friedman
  • Article |

    An integrated high-dimensional measurement of immune age describes a person’s immune status better than chronological age and predicts all-cause mortality.

    • Ayelet Alpert
    • , Yishai Pickman
    • , Michael Leipold
    • , Yael Rosenberg-Hasson
    • , Xuhuai Ji
    • , Renaud Gaujoux
    • , Hadas Rabani
    • , Elina Starosvetsky
    • , Ksenya Kveler
    • , Steven Schaffert
    • , David Furman
    • , Oren Caspi
    • , Uri Rosenschein
    • , Purvesh Khatri
    • , Cornelia L. Dekker
    • , Holden T. Maecker
    • , Mark M. Davis
    •  & Shai S. Shen-Orr
  • Article |

    Blockade of ERK signaling in KRAS-mutant pancreatic cancer increases the dependence on autophagic flux through different mechanisms and provides a rationale for combinatorial targeting with autophagy inhibitors.

    • Kirsten L. Bryant
    • , Clint A. Stalnecker
    • , Daniel Zeitouni
    • , Jennifer E. Klomp
    • , Sen Peng
    • , Andrey P. Tikunov
    • , Venugopal Gunda
    • , Mariaelena Pierobon
    • , Andrew M. Waters
    • , Samuel D. George
    • , Garima Tomar
    • , Björn Papke
    • , G. Aaron Hobbs
    • , Liang Yan
    • , Tikvah K. Hayes
    • , J. Nathaniel Diehl
    • , Gennifer D. Goode
    • , Nina V. Chaika
    • , Yingxue Wang
    • , Guo-Fang Zhang
    • , Agnieszka K. Witkiewicz
    • , Erik S. Knudsen
    • , Emanuel F. Petricoin III
    • , Pankaj K. Singh
    • , Jeffrey M. Macdonald
    • , Nhan L. Tran
    • , Costas A. Lyssiotis
    • , Haoqiang Ying
    • , Alec C. Kimmelman
    • , Adrienne D. Cox
    •  & Channing J. Der
  • Article |

    Blockade of sialic acid-binding protein Siglec-15 expressed in cancer and tumor-infiltrating myeloid cells reverses immunesupression and represents a novel target for cancer immunotherapy independent from the PD-1/PD-L1 axis.

    • Jun Wang
    • , Jingwei Sun
    • , Linda N. Liu
    • , Dallas B. Flies
    • , Xinxin Nie
    • , Maria Toki
    • , Jianping Zhang
    • , Chang Song
    • , Melissa Zarr
    • , Xu Zhou
    • , Xue Han
    • , Kristina A. Archer
    • , Thomas O’Neill
    • , Roy S. Herbst
    • , Agedi N. Boto
    • , Miguel F. Sanmamed
    • , Solomon Langermann
    • , David L. Rimm
    •  & Lieping Chen
  • Article |

    Neoadjuvant pembrolizumab promotes a survival benefit with intratumoral and systemic immune responses in patients with recurrent glioblastoma.

    • Timothy F. Cloughesy
    • , Aaron Y. Mochizuki
    • , Joey R. Orpilla
    • , Willy Hugo
    • , Alexander H. Lee
    • , Tom B. Davidson
    • , Anthony C. Wang
    • , Benjamin M. Ellingson
    • , Julie A. Rytlewski
    • , Catherine M. Sanders
    • , Eric S. Kawaguchi
    • , Lin Du
    • , Gang Li
    • , William H. Yong
    • , Sarah C. Gaffey
    • , Adam L. Cohen
    • , Ingo K. Mellinghoff
    • , Eudocia Q. Lee
    • , David A. Reardon
    • , Barbara J. O’Brien
    • , Nicholas A. Butowski
    • , Phioanh L. Nghiemphu
    • , Jennifer L. Clarke
    • , Isabel C. Arrillaga-Romany
    • , Howard Colman
    • , Thomas J. Kaley
    • , John F. de Groot
    • , Linda M. Liau
    • , Patrick Y. Wen
    •  & Robert M. Prins
  • Article |

    ApoE is a direct checkpoint inhibitor of unresolvable inflammation in neurodegenerative and cardiovascular diseases

    • Changjun Yin
    • , Susanne Ackermann
    • , Zhe Ma
    • , Sarajo K. Mohanta
    • , Chuankai Zhang
    • , Yuanfang Li
    • , Sandor Nietzsche
    • , Martin Westermann
    • , Li Peng
    • , Desheng Hu
    • , Sai Vineela Bontha
    • , Prasad Srikakulapu
    • , Michael Beer
    • , Remco T. A. Megens
    • , Sabine Steffens
    • , Markus Hildner
    • , Luke D. Halder
    • , Hans-Henning Eckstein
    • , Jaroslav Pelisek
    • , Jochen Herms
    • , Sigrun Roeber
    • , Thomas Arzberger
    • , Anna Borodovsky
    • , Livia Habenicht
    • , Christoph J. Binder
    • , Christian Weber
    • , Peter F. Zipfel
    • , Christine Skerka
    •  & Andreas J. R. Habenicht
  • Article |

    A disturbed microbial network characterizes relapsing refractory Crohn’s disease and antedates disease recurrence after surgical removal of the active disease segment.

    • Bahtiyar Yilmaz
    • , Pascal Juillerat
    • , Ove Øyås
    • , Charlotte Ramon
    • , Francisco Damian Bravo
    • , Yannick Franc
    • , Nicolas Fournier
    • , Pierre Michetti
    • , Christoph Mueller
    • , Markus Geuking
    • , Valerie E. H. Pittet
    • , Michel H. Maillard
    • , Gerhard Rogler
    • , Karim Abdelrahman
    • , Gentiana Ademi
    • , Patrick Aepli
    • , Amman Thomas
    • , Claudia Anderegg
    • , Anca-Teodora Antonino
    • , Eva Archanioti
    • , Eviano Arrigoni
    • , Diana Bakker de Jong
    • , Bruno Balsiger
    • , Polat Bastürk
    • , Peter Bauerfeind
    • , Andrea Becocci
    • , Dominique Belli
    • , José M. Bengoa
    • , Luc Biedermann
    • , Janek Binek
    • , Mirjam Blattmann
    • , Stephan Boehm
    • , Tujana Boldanova
    • , Jan Borovicka
    • , Christian P. Braegger
    • , Stephan Brand
    • , Lukas Brügger
    • , Simon Brunner
    • , Patrick Bühr
    • , Bernard Burnand
    • , Sabine Burk
    • , Emanuel Burri
    • , Sophie Buyse
    • , Dahlia-Thao Cao
    • , Ove Carstens
    • , Dominique H. Criblez
    • , Sophie Cunningham
    • , Fabrizia D’Angelo
    • , Philippe de Saussure
    • , Lukas Degen
    • , Joakim Delarive
    • , Christopher Doerig
    • , Barbara Dora
    • , Susan Drerup
    • , Mara Egger
    • , Ali El-Wafa
    • , Matthias Engelmann
    • , Jessica Ezri
    • , Christian Felley
    • , Markus Fliegner
    • , Nicolas Fournier
    • , Montserrat Fraga
    • , Yannick Franc
    • , Pascal Frei
    • , Remus Frei
    • , Michael Fried
    • , Florian Froehlich
    • , Raoul Ivano Furlano
    • , Luca Garzoni
    • , Martin Geyer
    • , Laurent Girard
    • , Marc Girardin
    • , Delphine Golay
    • , Ignaz Good
    • , Ulrike Graf Bigler
    • , Beat Gysi
    • , Johannes Haarer
    • , Marcel Halama
    • , Janine Haldemann
    • , Pius Heer
    • , Benjamin Heimgartner
    • , Beat Helbling
    • , Peter Hengstler
    • , Denise Herzog
    • , Cyrill Hess
    • , Roxane Hessler
    • , Klaas Heyland
    • , Thomas Hinterleitner
    • , Claudia Hirschi
    • , Petr Hruz
    • , Pascal Juillerat
    • , Carolina Khalid-de Bakker
    • , Stephan Kayser
    • , Céline Keller
    • , Christina Knellwolf (-Grieger)
    • , Christoph Knoblauch
    • , Henrik Köhler
    • , Rebekka Koller
    • , Claudia Krieger(-Grübel)
    • , Patrizia Künzler
    • , Rachel Kusche
    • , Frank Serge Lehmann
    • , Andrew J. Macpherson
    • , Michel H. Maillard
    • , Michael Manz
    • , Astrid Marot
    • , Rémy Meier
    • , Christa Meyenberger
    • , Pamela Meyer
    • , Pierre Michetti
    • , Benjamin Misselwitz
    • , Patrick Mosler
    • , Christian Mottet
    • , Christoph Müller
    • , Beat Müllhaupt
    • , Leilla Musso
    • , Michaela Neagu
    • , Cristina Nichita
    • , Jan Niess
    • , Andreas Nydegger
    • , Nicole Obialo
    • , Diana Ollo
    • , Cassandra Oropesa
    • , Ulrich Peter
    • , Daniel Peternac
    • , Laetitia Marie Petit
    • , Valérie Pittet
    • , Daniel Pohl
    • , Marc Porzner
    • , Claudia Preissler
    • , Nadia Raschle
    • , Ronald Rentsch
    • , Alexandre Restellini
    • , Sophie Restellini
    • , Jean-Pierre Richterich
    • , Frederic Ris
    • , Branislav Risti
    • , Marc Alain Ritz
    • , Gerhard Rogler
    • , Nina Röhrich
    • , Jean-Benoît Rossel
    • , Vanessa Rueger
    • , Monica Rusticeanu
    • , Markus Sagmeister
    • , Gaby Saner
    • , Bernhard Sauter
    • , Mikael Sawatzki
    • , Michael Scharl
    • , Martin Schelling
    • , Susanne Schibli
    • , Hugo Schlauri
    • , Dominique Schluckebier
    • , Daniela Schmid
    • , Sybille Schmid (-Uebelhart)
    • , Jean-François Schnegg
    • , Alain Schoepfer
    • , Vivianne Seematter
    • , Frank Seibold
    • , Mariam Seirafi
    • , Gian-Marco Semadeni
    • , Arne Senning
    • , Christiane Sokollik
    • , Joachim Sommer
    • , Johannes Spalinger
    • , Holger Spangenberger
    • , Philippe Stadler
    • , Peter Staub
    • , Dominic Staudenmann
    • , Volker Stenz
    • , Michael Steuerwald
    • , Alex Straumann
    • , Bruno Strebel
    • , Andreas Stulz
    • , Michael Sulz
    • , Aurora Tatu
    • , Michela Tempia-Caliera
    • , Joël Thorens
    • , Kaspar Truninger
    • , Radu Tutuian
    • , Patrick Urfer
    • , Stephan Vavricka
    • , Francesco Viani
    • , Jürg Vögtlin
    • , Roland Von Känel
    • , Dominique Vouillamoz
    • , Rachel Vulliamy
    • , Paul Wiesel
    • , Reiner Wiest
    • , Stefanie Wöhrle
    • , Samuel Zamora
    • , Silvan Zander
    • , Tina Wylie
    • , Jonas Zeitz
    • , Dorothee Zimmermann
    • , Reiner Wiest
    • , Jörg Stelling
    •  & Andrew J. Macpherson
  • Article |

    Oncogene cooperation enhances PD-L1 translation to promote immune evasion and metastasis in a novel model of liver cancer.

    • Yichen Xu
    • , Mauro Poggio
    • , Hyun Yong Jin
    • , Zhen Shi
    • , Craig M. Forester
    • , Ying Wang
    • , Craig R. Stumpf
    • , Lingru Xue
    • , Emily Devericks
    • , Lomon So
    • , Hao G. Nguyen
    • , Alice Griselin
    • , John D. Gordan
    • , Sarah E Umetsu
    • , Siegfried H. Reich
    • , Stephen T. Worland
    • , Saurabh Asthana
    • , Maria Barna
    • , Kevin R. Webster
    • , John T. Cunningham
    •  & Davide Ruggero
  • Article |

    Expression of the exercise-induced myokine irisin (FNDC5) is lower in patients with AD. Whereas knockdown of FNDC5/irisin is sufficient to induce learning and memory deficits, restoration of its expression can ameliorate these phenotypes in rodent models.

    • Mychael V. Lourenco
    • , Rudimar L. Frozza
    • , Guilherme B. de Freitas
    • , Hong Zhang
    • , Grasielle C. Kincheski
    • , Felipe C. Ribeiro
    • , Rafaella A. Gonçalves
    • , Julia R. Clarke
    • , Danielle Beckman
    • , Agnieszka Staniszewski
    • , Hanna Berman
    • , Lorena A. Guerra
    • , Letícia Forny-Germano
    • , Shelby Meier
    • , Donna M. Wilcock
    • , Jorge M. de Souza
    • , Soniza Alves-Leon
    • , Vania F. Prado
    • , Marco A. M. Prado
    • , Jose F. Abisambra
    • , Fernanda Tovar-Moll
    • , Paulo Mattos
    • , Ottavio Arancio
    • , Sergio T. Ferreira
    •  & Fernanda G. De Felice
  • Article |

    Single cell dissection of plasma cell heterogeneity in myeloma patients reveals new insights into disease that may inform early diagnosis and clinical management.

    • Guy Ledergor
    • , Assaf Weiner
    • , Mor Zada
    • , Shuang-Yin Wang
    • , Yael C. Cohen
    • , Moshe E. Gatt
    • , Nimrod Snir
    • , Hila Magen
    • , Maya Koren-Michowitz
    • , Katrin Herzog-Tzarfati
    • , Hadas Keren-Shaul
    • , Chamutal Bornstein
    • , Ron Rotkopf
    • , Ido Yofe
    • , Eyal David
    • , Venkata Yellapantula
    • , Sigalit Kay
    • , Moshe Salai
    • , Dina Ben Yehuda
    • , Arnon Nagler
    • , Lev Shvidel
    • , Avi Orr-Urtreger
    • , Keren Bahar Halpern
    • , Shalev Itzkovitz
    • , Ola Landgren
    • , Jesus San-Miguel
    • , Bruno Paiva
    • , Jonathan J. Keats
    • , Elli Papaemmanuil
    • , Irit Avivi
    • , Gabriel I. Barbash
    • , Amos Tanay
    •  & Ido Amit
  • Article |

    Evolutionarily conserved gene modules mediate neurodegenerative dementia in a variety of mouse models and in postmortem brain tissue from patients.

    • Vivek Swarup
    • , Flora I. Hinz
    • , Jessica E. Rexach
    • , Ken-ichi Noguchi
    • , Hiroyoshi Toyoshiba
    • , Akira Oda
    • , Keisuke Hirai
    • , Arjun Sarkar
    • , Nicholas T. Seyfried
    • , Chialin Cheng
    • , Stephen J. Haggarty
    • , Raffaele Ferrari
    • , Jonathan D. Rohrer
    • , Adaikalavan Ramasamy
    • , John Hardy
    • , Dena G. Hernandez
    • , Michael A. Nalls
    • , Andrew B. Singleton
    • , John B. J. Kwok
    • , Carol Dobson-Stone
    • , William S. Brooks
    • , Peter R. Schofield
    • , Glenda M. Halliday
    • , John R. Hodges
    • , Olivier Piguet
    • , Lauren Bartley
    • , Elizabeth Thompson
    • , Eric Haan
    • , Isabel Hernández
    • , Agustín Ruiz
    • , Mercè Boada
    • , Barbara Borroni
    • , Alessandro Padovani
    • , Nigel J. Cairns
    • , Carlos Cruchaga
    • , Giuliano Binetti
    • , Roberta Ghidoni
    • , Luisa Benussi
    • , Gianluigi Forloni
    • , Diego Albani
    • , Daniela Galimberti
    • , Chiara Fenoglio
    • , Maria Serpente
    • , Elio Scarpini
    • , Jordi Clarimón
    • , Alberto Lleó
    • , Rafael Blesa
    • , Maria Landqvist Waldö
    • , Karin Nilsson
    • , Christer Nilsson
    • , Ian R. A. Mackenzie
    • , Ging-Yuek R. Hsiung
    • , David M. A. Mann
    • , Jordan Grafman
    • , Christopher M. Morris
    • , Johannes Attems
    • , Timothy D. Griffiths
    • , Ian G. McKeith
    • , Alan J. Thomas
    • , Evelyn Jaros
    • , Pietro Pietrini
    • , Edward D. Huey
    • , Eric M. Wassermann
    • , Michael C. Tierney
    • , Atik Baborie
    • , Pau Pastor
    • , Sara Ortega-Cubero
    • , Cristina Razquin
    • , Elena Alonso
    • , Robert Perneczky
    • , Janine Diehl-Schmid
    • , Panagiotis Alexopoulos
    • , Alexander Kurz
    • , Innocenzo Rainero
    • , Elisa Rubino
    • , Lorenzo Pinessi
    • , Ekaterina Rogaeva
    • , Peter St. George-Hyslop
    • , Giacomina Rossi
    • , Fabrizio Tagliavini
    • , Giorgio Giaccone
    • , James B. Rowe
    • , Johannes C. M. Schlachetzki
    • , James Uphill
    • , John Collinge
    • , Simon Mead
    • , Adrian Danek
    • , Vivianna M. Van Deerlin
    • , Murray Grossman
    • , John Q. Trojanowski
    • , Stuart Pickering-Brown
    • , Parastoo Momeni
    • , Julie van der Zee
    • , Marc Cruts
    • , Christine Van Broeckhoven
    • , Stefano F. Cappa
    • , Isabelle Leber
    • , Alexis Brice
    • , Didier Hannequin
    • , Véronique Golfier
    • , Martine Vercelletto
    • , Benedetta Nacmias
    • , Sandro Sorbi
    • , Silvia Bagnoli
    • , Irene Piaceri
    • , Jørgen E. Nielsen
    • , Lena E. Hjermind
    • , Matthias Riemenschneider
    • , Manuel Mayhaus
    • , Gilles Gasparoni
    • , Sabrina Pichler
    • , Bernd Ibach
    • , Martin N. Rossor
    • , Nick C. Fox
    • , Jason D. Warren
    • , Maria Grazia Spillantini
    • , Huw R. Morris
    • , Patrizia Rizzu
    • , Peter Heutink
    • , Julie S. Snowden
    • , Sara Rollinson
    • , Alexander Gerhard
    • , Anna Richardson
    • , Amalia C. Bruni
    • , Raffaele Maletta
    • , Francesca Frangipane
    • , Chiara Cupidi
    • , Livia Bernardi
    • , Maria Anfossi
    • , Maura Gallo
    • , Maria Elena Conidi
    • , Nicoletta Smirne
    • , Rosa Rademakers
    • , Matt Baker
    • , Dennis W. Dickson
    • , Neill R. Graff-Radford
    • , Ronald C. Petersen
    • , David Knopman
    • , Keith A. Josephs
    • , Bradley F. Boeve
    • , Joseph E. Parisi
    • , Bruce L. Miller
    • , Anna M. Karydas
    • , Howard Rosen
    • , William W. Seeley
    • , John C. van Swieten
    • , Elise G. P. Dopper
    • , Harro Seelaar
    • , Yolande A. L. Pijnenburg
    • , Philip Scheltens
    • , Giancarlo Logroscino
    • , Rosa Capozzo
    • , Valeria Novelli
    • , Annibale A. Puca
    • , Massimo Franceschi
    • , Alfredo Postiglione
    • , Graziella Milan
    • , Paolo Sorrentino
    • , Mark Kristiansen
    • , Huei-Hsin Chiang
    • , Caroline Graff
    • , Florence Pasquier
    • , Adeline Rollin
    • , Vincent Deramecourt
    • , Thibaud Lebouvier
    • , Luigi Ferrucci
    • , Dimitrios Kapogiannis
    • , Murray Grossman
    • , Vivianna M. Van Deerlin
    • , John Q. Trojanowski
    • , James J. Lah
    • , Allan I. Levey
    • , Shinichi Kondou
    •  & Daniel H. Geschwind
  • Article |

    WASP is a novel tumor-suppressor gene in ALK-driven anaplastic large cell lymphoma through modulation of CDC42 and MAPK signaling and provides a rationale for combination therapy.

    • Matteo Menotti
    • , Chiara Ambrogio
    • , Taek-Chin Cheong
    • , Chiara Pighi
    • , Ines Mota
    • , Seth H. Cassel
    • , Mara Compagno
    • , Qi Wang
    • , Riccardo Dall’Olio
    • , Valerio G. Minero
    • , Teresa Poggio
    • , Geeta Geeta Sharma
    • , Enrico Patrucco
    • , Cristina Mastini
    • , Ramesh Choudhari
    • , Achille Pich
    • , Alberto Zamo
    • , Roberto Piva
    • , Silvia Giliani
    • , Luca Mologni
    • , Clayton K. Collings
    • , Cigall Kadoch
    • , Carlo Gambacorti-Passerini
    • , Luigi D. Notarangelo
    • , Ines M. Anton
    • , Claudia Voena
    •  & Roberto Chiarle
  • Article |

    ONECUT2 is a targetable transcription factor that antagonizes androgen receptor signaling and drives androgen independence and neuroendocrine differentiation in castration-resistant prostate cancer.

    • Mirja Rotinen
    • , Sungyong You
    • , Julie Yang
    • , Simon G. Coetzee
    • , Mariana Reis-Sobreiro
    • , Wen-Chin Huang
    • , Fangjin Huang
    • , Xinlei Pan
    • , Alberto Yáñez
    • , Dennis J. Hazelett
    • , Chia-Yi Chu
    • , Kenneth Steadman
    • , Colm M. Morrissey
    • , Peter S. Nelson
    • , Eva Corey
    • , Leland W. K. Chung
    • , Stephen J. Freedland
    • , Dolores Di Vizio
    • , Isla P. Garraway
    • , Ramachandran Murali
    • , Beatrice S. Knudsen
    •  & Michael R. Freeman
  • Article |

    Molecular alterations in ctDNA of patients with mantle cell lymphoma uncovers mutations in SWI–SNF associated with resistance to ibrutinib and venetoclax combination and provide a rationale for restoring sensitivity through Bcl-xL inhibition.

    • Rishu Agarwal
    • , Yih-Chih Chan
    • , Constantine S. Tam
    • , Tane Hunter
    • , Dane Vassiliadis
    • , Charis E. Teh
    • , Rachel Thijssen
    • , Paul Yeh
    • , Stephen Q. Wong
    • , Sarah Ftouni
    • , Enid Y. N. Lam
    • , Mary Ann Anderson
    • , Christiane Pott
    • , Omer Gilan
    • , Charles C. Bell
    • , Kathy Knezevic
    • , Piers Blombery
    • , Kathleen Rayeroux
    • , Adrian Zordan
    • , Jason Li
    • , David C. S. Huang
    • , Meaghan Wall
    • , John F. Seymour
    • , Daniel H. D. Gray
    • , Andrew W. Roberts
    • , Mark A. Dawson
    •  & Sarah-Jane Dawson
  • Article |

    Targeting of mitochondrial metabolism in combination with BCL-2 inhibition eradicates leukemia stem cells and induces long-lasting responses in patients with acute myeloid leukemia.

    • Daniel A. Pollyea
    • , Brett M. Stevens
    • , Courtney L. Jones
    • , Amanda Winters
    • , Shanshan Pei
    • , Mohammad Minhajuddin
    • , Angelo D’Alessandro
    • , Rachel Culp-Hill
    • , Kent A. Riemondy
    • , Austin E. Gillen
    • , Jay R. Hesselberth
    • , Diana Abbott
    • , Derek Schatz
    • , Jonathan A. Gutman
    • , Enkhtsetseg Purev
    • , Clayton Smith
    •  & Craig T. Jordan
  • Article |

    Obesity promotes tumor growth yet simultaneously increases susceptibility to PD-1-targeted cancer immunotherapy.

    • Ziming Wang
    • , Ethan G. Aguilar
    • , Jesus I. Luna
    • , Cordelia Dunai
    • , Lam T. Khuat
    • , Catherine T. Le
    • , Annie Mirsoian
    • , Christine M. Minnar
    • , Kevin M. Stoffel
    • , Ian R. Sturgill
    • , Steven K. Grossenbacher
    • , Sita S. Withers
    • , Robert B. Rebhun
    • , Dennis J. Hartigan-O’Connor
    • , Gema Méndez-Lagares
    • , Alice F. Tarantal
    • , R. Rivkah Isseroff
    • , Thomas S. Griffith
    • , Kurt A. Schalper
    • , Alexander Merleev
    • , Asim Saha
    • , Emanual Maverakis
    • , Karen Kelly
    • , Raid Aljumaily
    • , Sami Ibrahimi
    • , Sarbajit Mukherjee
    • , Michael Machiorlatti
    • , Sara K. Vesely
    • , Dan L. Longo
    • , Bruce R. Blazar
    • , Robert J. Canter
    • , William J. Murphy
    •  & Arta M. Monjazeb
  • Article |

    A novel orphan noncoding RNA species with tumor-specific expression across breast cancer subtypes promotes metastatic progression and holds potential for patient diagnosis.

    • Lisa Fish
    • , Steven Zhang
    • , Johnny X. Yu
    • , Bruce Culbertson
    • , Alicia Y. Zhou
    • , Andrei Goga
    •  & Hani Goodarzi
  • Article | | open

    Analysis of tuberculosis drug trials identifies features to stratify patients for longer or shorter treatment duration than the standard of care, in order to improve therapeutic outcomes.

    • Marjorie Z. Imperial
    • , Payam Nahid
    • , Patrick P. J. Phillips
    • , Geraint R. Davies
    • , Katherine Fielding
    • , Debra Hanna
    • , David Hermann
    • , Robert S. Wallis
    • , John L. Johnson
    • , Christian Lienhardt
    •  & Rada M. Savic
  • Article |

    Metformin decreases the levels of Bacteroides fragilis while increasing the bile acid GUDCA to antagonize intestinal FXR and improves the metabolic health of humans and mice.

    • Lulu Sun
    • , Cen Xie
    • , Guang Wang
    • , Yue Wu
    • , Qing Wu
    • , Xuemei Wang
    • , Jia Liu
    • , Yangyang Deng
    • , Jialin Xia
    • , Bo Chen
    • , Songyang Zhang
    • , Chuyu Yun
    • , Guan Lian
    • , Xiujuan Zhang
    • , Heng Zhang
    • , William H. Bisson
    • , Jingmin Shi
    • , Xiaoxia Gao
    • , Pupu Ge
    • , Cuihua Liu
    • , Kristopher W. Krausz
    • , Robert G. Nichols
    • , Jingwei Cai
    • , Bipin Rimal
    • , Andrew D. Patterson
    • , Xian Wang
    • , Frank J. Gonzalez
    •  & Changtao Jiang
  • Article |

    Cross-sectional and longitudinal PET imaging of amyloid beta and tau in the human brain is combined with gene expression profiles to define the interactions between Alzheimer’s disease-related pathology propagation and brain-region-specific vulnerability.

    • Jorge Sepulcre
    • , Michel J. Grothe
    • , Federico d’Oleire Uquillas
    • , Laura Ortiz-Terán
    • , Ibai Diez
    • , Hyun-Sik Yang
    • , Heidi I. L. Jacobs
    • , Bernard J. Hanseeuw
    • , Quanzheng Li
    • , Georges El-Fakhri
    • , Reisa A. Sperling
    •  & Keith A. Johnson
  • Article |

    The translation initiation complex mediates tumor immune escape in melanoma by controlling STAT1 mRNA levels and T lymphocyte–induced PD-L1 expression.

    • Michaël Cerezo
    • , Ramdane Guemiri
    • , Sabine Druillennec
    • , Isabelle Girault
    • , Hélène Malka-Mahieu
    • , Shensi Shen
    • , Delphine Allard
    • , Sylvain Martineau
    • , Caroline Welsch
    • , Sandrine Agoussi
    • , Charlène Estrada
    • , Julien Adam
    • , Cristina Libenciuc
    • , Emilie Routier
    • , Séverine Roy
    • , Laurent Désaubry
    • , Alexander M. Eggermont
    • , Nahum Sonenberg
    • , Jean Yves Scoazec
    • , Alain Eychène
    • , Stéphan Vagner
    •  & Caroline Robert
  • Article |

    Targeting different aspects of mutant CFTR structural defects with combination therapy leads to more potent rescue of function than that following single therapy.

    • Guido Veit
    • , Haijin Xu
    • , Elise Dreano
    • , Radu G. Avramescu
    • , Miklos Bagdany
    • , Lenore K. Beitel
    • , Ariel Roldan
    • , Mark A. Hancock
    • , Cecilia Lay
    • , Wei Li
    • , Katelin Morin
    • , Sandra Gao
    • , Puiying A. Mak
    • , Edward Ainscow
    • , Anthony P. Orth
    • , Peter McNamara
    • , Aleksander Edelman
    • , Saul Frenkiel
    • , Elias Matouk
    • , Isabelle Sermet-Gaudelus
    • , William G. Barnes
    •  & Gergely L. Lukacs
  • Article |

    Systemic administration of human PBGD mRNA encapsulated in lipid nanoparticles ameliorates disease phenotypes in mouse and rabbit models of acute hepatic porphyria and is safe in nonhuman primates.

    • Lei Jiang
    • , Pedro Berraondo
    • , Daniel Jericó
    • , Lin T. Guey
    • , Ana Sampedro
    • , Andrea Frassetto
    • , Kerry E. Benenato
    • , Kristine Burke
    • , Eva Santamaría
    • , Manuel Alegre
    • , Álvaro Pejenaute
    • , Mayur Kalariya
    • , William Butcher
    • , Ji-Sun Park
    • , Xuling Zhu
    • , Staci Sabnis
    • , E. Sathyajith Kumarasinghe
    • , Timothy Salerno
    • , Matthew Kenney
    • , Christine M. Lukacs
    • , Matías A. Ávila
    • , Paolo G. V. Martini
    •  & Antonio Fontanellas
  • Article |

    Kidney compartment–specific eQTL analysis goes beyond GWAS to reveal causal genes and pathways involved in renal disease development.

    • Chengxiang Qiu
    • , Shizheng Huang
    • , Jihwan Park
    • , YoSon Park
    • , Yi-An Ko
    • , Matthew J. Seasock
    • , Joshua S. Bryer
    • , Xiang-Xi Xu
    • , Wen-Chao Song
    • , Matthew Palmer
    • , Jon Hill
    • , Paolo Guarnieri
    • , Julie Hawkins
    • , Carine M. Boustany-Kari
    • , Steven S. Pullen
    • , Christopher D. Brown
    •  & Katalin Susztak
  • Article |

    Interdependence between YAP/TAZ and BRD4 drives transcriptional addiction in cancer cells and determines sensitivity to BET inhibition.

    • Francesca Zanconato
    • , Giusy Battilana
    • , Mattia Forcato
    • , Letizia Filippi
    • , Luca Azzolin
    • , Andrea Manfrin
    • , Erika Quaranta
    • , Daniele Di Biagio
    • , Gianluca Sigismondo
    • , Vincenza Guzzardo
    • , Pascale Lejeune
    • , Bernard Haendler
    • , Jeroen Krijgsveld
    • , Matteo Fassan
    • , Silvio Bicciato
    • , Michelangelo Cordenonsi
    •  & Stefano Piccolo
  • Article |

    A convolutional neural network model using feature extraction and machine-learning techniques provides a tool for classification of lung cancer histopathology images and predicting mutational status of driver oncogenes

    • Nicolas Coudray
    • , Paolo Santiago Ocampo
    • , Theodore Sakellaropoulos
    • , Navneet Narula
    • , Matija Snuderl
    • , David Fenyö
    • , Andre L. Moreira
    • , Narges Razavian
    •  & Aristotelis Tsirigos
  • Article |

    Distinct routes of immunization elicit different antibody isotypes and functions associated with protection against SIV infection that converge on phagocytosis as a candidate protective mechanism of independent SIV vaccines.

    • Margaret E. Ackerman
    • , Jishnu Das
    • , Srivamshi Pittala
    • , Thomas Broge
    • , Caitlyn Linde
    • , Todd J. Suscovich
    • , Eric P. Brown
    • , Todd Bradley
    • , Harini Natarajan
    • , Shu Lin
    • , Jessica K. Sassic
    • , Sean O’Keefe
    • , Nickita Mehta
    • , Derrick Goodman
    • , Magdalena Sips
    • , Joshua A. Weiner
    • , Georgia D. Tomaras
    • , Barton F. Haynes
    • , Douglas A. Lauffenburger
    • , Chris Bailey-Kellogg
    • , Mario Roederer
    •  & Galit Alter
  • Article |

    The antidiabetic action of metformin raises heptocyte intracellular AMP levels, causing allosteric inhibition of fructose-1,6-bisphosphatase and thus reductions in gluconeogenesis.

    • Roger W. Hunter
    • , Curtis C. Hughey
    • , Louise Lantier
    • , Elias I. Sundelin
    • , Mark Peggie
    • , Elton Zeqiraj
    • , Frank Sicheri
    • , Niels Jessen
    • , David H. Wasserman
    •  & Kei Sakamoto
  • Article |

    Impaired NAD+ biosynthesis may be a common feature of high-risk hospitalizations for which NAD+ augmentation could improve therapeutic outcome.

    • Ali Poyan Mehr
    • , Mei T. Tran
    • , Kenneth M. Ralto
    • , David E. Leaf
    • , Vaughan Washco
    • , Joseph Messmer
    • , Adam Lerner
    • , Ajay Kher
    • , Steven H. Kim
    • , Charbel C. Khoury
    • , Shoshana J. Herzig
    • , Mary E. Trovato
    • , Noemie Simon-Tillaux
    • , Matthew R. Lynch
    • , Ravi I. Thadhani
    • , Clary B. Clish
    • , Kamal R. Khabbaz
    • , Eugene P. Rhee
    • , Sushrut S. Waikar
    • , Anders H. Berg
    •  & Samir M. Parikh
  • Article |

    iPSC-derived motor neurons from over 30 heterogeneous sporadic ALS cases exhibit pathologies correlated with clinical disease progression, are more similar to FUS/TDP-43 familial ALS than SOD1-ALS and are corrected by repurposing of ropinirole.

    • Koki Fujimori
    • , Mitsuru Ishikawa
    • , Asako Otomo
    • , Naoki Atsuta
    • , Ryoichi Nakamura
    • , Tetsuya Akiyama
    • , Shinji Hadano
    • , Masashi Aoki
    • , Hideyuki Saya
    • , Gen Sobue
    •  & Hideyuki Okano