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In an updated systematic review and meta-analysis, fixed-dose combination therapy using a polypill with at least one blood pressure-lowering drug and one lipid-lowering drug was found to reduce both incident cardiovascular disease and all-cause mortality.
The first report from the Cancer Programme of the 100,000 Genomes Project presents whole-genome sequencing profiles of 13,880 solid tumors spanning 33 cancer types, combined with real-world clinical data, providing insights for precision oncology.
Systematic evaluation of literature in four databases to generate an evidence gap map for noncommunicable disease interventions in children and adolescents shows that over 90% of studies have been done in high-income countries and that evidence for interventions for mental health conditions, obesity and substance misuse is lacking globally.