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Neurological phenotypes of PTEN loss are driven by aberrant mTORC2 signaling, and therapeutic inhibition of the mTORC2 component Rictor by antisense oligonucleotides reverses seizures, social interaction deficits and memory impairments in rodents.
An engineered truncated gene derived from the dystrophin-related protein (utrophin), prevents pathology without an immune response in an animal model of Duchenne muscular dystrophy (DMD) gene therapy.
Antibodies elicited by the widely deployed rVSV-EBOV Ebola virus vaccine mirror those of disease survivors, animal models and other vaccine platforms. Notably, neutralizing antibodies are consistently elicited from a recurring pair of germline genes.
Patrícia Brasil is head of the Laboratory of Acute Febrile Illness of the National Institute of Infectious Diseases Evandro Chagas, Fiocruz, and professor of tropical medicine and clinical research in the postgraduate programs of Fiocruz in Rio de Janeiro, Brazil.
A novel oral capsule can deploy microneedle patches that release drugs into the intestinal wall for uptake into the bloodstream as shown in animal studies, thereby avoiding injections.
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