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Abi-Dargham and Horga discuss the challenges of developing and standardizing brain-imaging technologies to aid with the diagnosis and treatment of psychiatric disorders.
In triple-negative breast cancer, the kinase PIM1, which is highly expressed, functions through the transcription factor c-MYC to promote tumor cell survival and growth.
In triple-negative breast cancer, the PIM1 kinase is highly expressed, acts to promote tumor cell survival and growth, and increases MYC transcriptional activity.
An immunotherapy consisting of a tumor-antigen targeting antibody, PD-1 blocking antibody, extended half-life recombinant IL-2 and a lymph-node-targeted T cell vaccine mobilized innate and adaptive immunity and eradicated large established tumors in a variety of mouse models.
Poor responses of liver metastases to the anti-angiogenic agent bevacizumab in patients with colorectal and breast cancer correlate with tumor co-option of pre-existing blood vessels, a mechanism of tumor resistance that might be targeted by the inhibition of cancer cell motility.
Whole-genome sequencing identified recurrent fusions involving the MET oncogene, and MET inhibitors suppressed tumor growth in mouse models and in a human patient.
Caspase-2-mediated cleavage of tau is shown to generate a fibrillation-resistant truncation product (Δtau314) that contributes to the missorting of tau into dendritic spines, synaptic dysfunction, neurodegeneration and cognitive impairments in mice.
In a new mouse model of multiple myeloma, mice expressing the human versions of six proteins important for hematopoietic function were able to support the growth of primary human multiple myeloma xenografts, including both preneoplastic and malignant plasma cells.
The suicide rate in the US is increasing, whereas funding for research into suicide prevention has decreased. It will take more investment to truly understand the mechanisms of action underlying the causes of this global killer and to design new treatments for those causes. But efforts must come from all segments of society.
Here, we announce two policy changes across Nature journals: data-availability statements in all published papers and official Worldwide Protein Data Bank (wwPDB) validation reports for peer review.
Tumors often overexpress enzymes that synthesize fatty acids, but the requirement for fatty acid synthesis in tumor growth is unclear. A new fatty acid–synthesis inhibitor blunts lung tumor growth in mice, which implicates this process as a targetable liability.
Two new studies show that high-resolution imaging can detect active tuberculosis (TB) in people otherwise diagnosed as healthy. Individuals with these signs of active infection with Mycobacterium tuberculosis (Mtb) were at an increased risk of developing clinical TB.