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Latest Research

  • Letter |

    A combination of clinical and molecular analyses supports an association between disorders of immune complement or coagulation with poor outcome in patients with SARS-CoV-2 infection.

    • Vijendra Ramlall
    • , Phyllis M. Thangaraj
    • , Cem Meydan
    • , Jonathan Foox
    • , Daniel Butler
    • , Jacob Kim
    • , Ben May
    • , Jessica K. De Freitas
    • , Benjamin S. Glicksberg
    • , Christopher E. Mason
    • , Nicholas P. Tatonetti
    •  & Sagi D. Shapira
  • Letter
    | Open Access

    Identification in Rwanda of mutations in Plasmodium falciparum capable of conferring in vitro resistance to artemisinin, an essential medicine for the treatment of malaria, underscore the crucial need for surveillance in Africa to safeguard efficacy of life-saving therapies.

    • Aline Uwimana
    • , Eric Legrand
    • , Barbara H. Stokes
    • , Jean-Louis Mangala Ndikumana
    • , Marian Warsame
    • , Noella Umulisa
    • , Daniel Ngamije
    • , Tharcisse Munyaneza
    • , Jean-Baptiste Mazarati
    • , Kaendi Munguti
    • , Pascal Campagne
    • , Alexis Criscuolo
    • , Frédéric Ariey
    • , Monique Murindahabi
    • , Pascal Ringwald
    • , David A. Fidock
    • , Aimable Mbituyumuremyi
    •  & Didier Menard
  • Article |

    Multimodal single-cell profiling reveals heterogeneity of colonic CD8+ T cells in patients with ulcerative colitis, including expansion of a chronically activated IL-26-expressing subpopulation with innate-like features.

    • Daniele Corridoni
    • , Agne Antanaviciute
    • , Tarun Gupta
    • , David Fawkner-Corbett
    • , Anna Aulicino
    • , Marta Jagielowicz
    • , Kaushal Parikh
    • , Emmanouela Repapi
    • , Steve Taylor
    • , Dai Ishikawa
    • , Ryo Hatano
    • , Taketo Yamada
    • , Wei Xin
    • , Hubert Slawinski
    • , Rory Bowden
    • , Giorgio Napolitani
    • , Oliver Brain
    • , Chikao Morimoto
    • , Hashem Koohy
    •  & Alison Simmons
  • Letter |

    Clinical sequencing across a large prospective cohort of patients with myelodysplasic syndrome uncovers distinct associations between the mono- and biallelic states of TP53 and clinical presentation

    • Elsa Bernard
    • , Yasuhito Nannya
    • , Robert P. Hasserjian
    • , Sean M. Devlin
    • , Heinz Tuechler
    • , Juan S. Medina-Martinez
    • , Tetsuichi Yoshizato
    • , Yusuke Shiozawa
    • , Ryunosuke Saiki
    • , Luca Malcovati
    • , Max F. Levine
    • , Juan E. Arango
    • , Yangyu Zhou
    • , Francesc Solé
    • , Catherine A. Cargo
    • , Detlef Haase
    • , Maria Creignou
    • , Ulrich Germing
    • , Yanming Zhang
    • , Gunes Gundem
    • , Araxe Sarian
    • , Arjan A. van de Loosdrecht
    • , Martin Jädersten
    • , Magnus Tobiasson
    • , Olivier Kosmider
    • , Matilde Y. Follo
    • , Felicitas Thol
    • , Ronald F. Pinheiro
    • , Valeria Santini
    • , Ioannis Kotsianidis
    • , Jacqueline Boultwood
    • , Fabio P. S. Santos
    • , Julie Schanz
    • , Senji Kasahara
    • , Takayuki Ishikawa
    • , Hisashi Tsurumi
    • , Akifumi Takaori-Kondo
    • , Toru Kiguchi
    • , Chantana Polprasert
    • , John M. Bennett
    • , Virginia M. Klimek
    • , Michael R. Savona
    • , Monika Belickova
    • , Christina Ganster
    • , Laura Palomo
    • , Guillermo Sanz
    • , Lionel Ades
    • , Matteo Giovanni Della Porta
    • , Alexandra G. Smith
    • , Yesenia Werner
    • , Minal Patel
    • , Agnès Viale
    • , Katelynd Vanness
    • , Donna S. Neuberg
    • , Kristen E. Stevenson
    • , Kamal Menghrajani
    • , Kelly L. Bolton
    • , Pierre Fenaux
    • , Andrea Pellagatti
    • , Uwe Platzbecker
    • , Michael Heuser
    • , Peter Valent
    • , Shigeru Chiba
    • , Yasushi Miyazaki
    • , Carlo Finelli
    • , Maria Teresa Voso
    • , Lee-Yung Shih
    • , Michaela Fontenay
    • , Joop H. Jansen
    • , José Cervera
    • , Yoshiko Atsuta
    • , Norbert Gattermann
    • , Benjamin L. Ebert
    • , Rafael Bejar
    • , Peter L. Greenberg
    • , Mario Cazzola
    • , Eva Hellström-Lindberg
    • , Seishi Ogawa
    •  & Elli Papaemmanuil
  • Letter |

    An antisense oligonucleotide induces exon skipping in cell lines derived from patients with CLN3 Batten disease, and reduces lysosomal impairment and ameliorates neurological phenotypes in a mouse model of the disease.

    • Jessica L. Centa
    • , Francine M. Jodelka
    • , Anthony J. Hinrich
    • , Tyler B. Johnson
    • , Joseph Ochaba
    • , Michaela Jackson
    • , Dominik M. Duelli
    • , Jill M. Weimer
    • , Frank Rigo
    •  & Michelle L. Hastings
  • Letter |

    Screening for a set of autosomal-dominant genetic conditions in a large, unselected cohort of individuals uncovers carriers who were missed by routine medical care, demonstrating the utility of broad genetic screening.

    • J. J. Grzymski
    • , G. Elhanan
    • , J. A. Morales Rosado
    • , E. Smith
    • , K. A. Schlauch
    • , R. Read
    • , C. Rowan
    • , N. Slotnick
    • , S. Dabe
    • , W. J. Metcalf
    • , B. Lipp
    • , H. Reed
    • , L. Sharma
    • , E. Levin
    • , J. Kao
    • , M. Rashkin
    • , J. Bowes
    • , K. Dunaway
    • , A. Slonim
    • , N. Washington
    • , M. Ferber
    • , A. Bolze
    •  & J. T. Lu

News & Comment

  • News & Views |

    Metformin can promote the regeneration of neural precursor cell populations and improve cognitive function in a preclinical model of cranial radiation and a pilot clinical study of children after cranial radiation and chemotherapy.

    • Erin M. Gibson
    •  & Michelle Monje
  • News & Views |

    The Healthy Nevada Project shows that otherwise invisible disease risk can be revealed through DNA-based screening. Identifying these monogenic risks could be the first step toward a new population health-screening program.

    • Michael F. Murray
    •  & Monica A. Giovanni
  • News & Views |

    The COVID-19 pandemic has highlighted the crucial importance of antibody surveys in estimating the incidence of SARS-CoV-2 infection at a population level. Studies in Brazil and China address the use of serology to obtain a better estimate of the infection rate.

    • Marion Koopmans
    •  & Bart Haagmans
  • Correspondence |

    • Alexander W. Charney
    • , Nicole W. Simons
    • , Konstantinos Mouskas
    • , Lauren Lepow
    • , Esther Cheng
    • , Jessica Le Berichel
    • , Christie Chang
    • , Robert Marvin
    • , Diane Marie Del Valle
    • , Sharlene Calorossi
    • , Alona Lansky
    • , Laura Walker
    • , Manishkumar Patel
    • , Hui Xie
    • , Nancy Yi
    • , Alex Yu
    • , Gurpawan Kang
    • , Lora E. Liharska
    • , Emily Moya
    • , Matthew Hartnett
    • , Sandra Hatem
    • , Lillian Wilkins
    • , Melody Eaton
    • , Hajra Jamal
    • , Kevin Tuballes
    • , Steven T. Chen
    • , Jonathan Chung
    • , Jocelyn Harris
    • , Craig Batchelor
    • , Jose Lacunza
    • , Mahlet Yishak
    • , Kimberly Argueta
    • , Neha Karekar
    • , Brian Lee
    • , Geoffrey Kelly
    • , Daniel Geanon
    • , Diana Handler
    • , John Leech
    • , Hiyab Stefanos
    • , Travis Dawson
    • , Ieisha Scott
    • , Nancy Francoeur
    • , Jessica S. Johnson
    • , Akhil Vaid
    • , Benjamin S. Glicksberg
    • , Girish N. Nadkarni
    • , Eric E. Schadt
    • , Bruce D. Gelb
    • , Adeeb Rahman
    • , Robert Sebra
    • , Glenn Martin
    • , Charuta Agashe
    • , Priyal Agrawal
    • , Kasey Alesso-Carra
    • , Eziwoma Alibo
    • , Kelvin Alvarez
    • , Angelo Amabile
    • , Steven Ascolillo
    • , Rasheed Bailey
    • , Priya Begani
    • , Paloma Bravo Correra
    • , Stacey-Ann Brown
    • , Mark Buckup
    • , Larissa Burka
    • , Lena Cambron
    • , Gina Carrara
    • , Serena Chang
    • , Jonathan Chien
    • , Mashkura Chowdhury
    • , Cansu Cimen Bozkus
    • , Phillip Comella
    • , Dana Cosgrove
    • , Francesca Cossarini
    • , Liam Cotter
    • , Arpit Dave
    • , Bheesham Dayal
    • , Maxime Dhainaut
    • , Rebecca Dornfeld
    • , Katie Dul
    • , Nissan Eber
    • , Cordelia Elaiho
    • , Frank Fabris
    • , Jeremiah Faith
    • , Dominique Falci
    • , Susie Feng
    • , Brian Fennessy
    • , Marie Fernandes
    • , Sandeep Gangadharan
    • , Joanna Grabowska
    • , Gavin Grimes
    • , Maha Hamdani
    • , Manon Herbinet
    • , Elva Herrera
    • , Arielle Hochman
    • , Gabriel E. Hoffman
    • , Jaime Hook
    • , Laila Horta
    • , Etienne Humblin
    • , Subha Karim
    • , Jessica Kim
    • , Dannielle Lebovitch
    • , Grace Lee
    • , Gyu Ho Lee
    • , Jacky Lee
    • , Mike Leventhal
    • , Katherine Lindblad
    • , Alexandra Livanos
    • , Rosalie Machado
    • , Zafar Mahmood
    • , Kelcey Mar
    • , Shrisha Maskey
    • , Paul Matthews
    • , Katherine Meckel
    • , Saurabh Mehandru
    • , Cynthia Mercedes
    • , Dara Meyer
    • , Gurkan Mollaoglu
    • , Sarah Morris
    • , Kai Nie
    • , Marjorie Nisenholtz
    • , George Ofori-Amanfo
    • , Kenan Onel
    • , Merouane Ounadjela
    • , Vishwendra Patel
    • , Cassandra Pruitt
    • , Shivani Rathi
    • , Jamie Redes
    • , Ivan Reyes-Torres
    • , Alcina Rodrigues
    • , Alfonso Rodriguez
    • , Vladimir Roudko
    • , Evelyn Ruiz
    • , Pearl Scalzo
    • , Pedro Silva
    • , Alessandra Soares Schanoski
    • , Meghan Straw
    • , Sasha Tabachnikova
    • , Collin Teague
    • , Bhaskar Upadhyaya
    • , Verena Van Der Heide
    • , Natalie Vaninov
    • , Daniel Wacker
    • , Hadley Walsh
    • , C. Matthias Wilk
    • , Jessica Wilson
    • , Karen M. Wilson
    • , Li Xue
    • , Naa-akomaah Yeboah
    • , Sabina Young
    • , Nina Zaks
    • , Renyuan Zha
    • , Thomas Marron
    • , Noam Beckmann
    • , Seunghee Kim-Schulze
    • , Sacha Gnjatic
    •  & Miriam Merad
  • World View |

    Every crisis is a strong call to mobilize the entire research community to respond. The COVID-19 pandemic is no exception. Researchers, universities, funders, philanthropies, journals, and journalists have all pivoted, en masse, to COVID-19. Everyone is ‘Covidized’, and it should worry us.

    • Madhukar Pai

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