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    Dysregulation of ribonucleoprotein complex granules, previously implicated in neuromuscular disease, can drive pathogenesis in a genetic form of dilated cardiomyopathy, as shown in gene-edited pigs and patient-derived cardiomyocytes.

    • Jay W. Schneider
    • , Saji Oommen
    • , Muhammad Y. Qureshi
    • , Sean C. Goetsch
    • , David R. Pease
    • , Rhianna S. Sundsbak
    • , Wei Guo
    • , Mingming Sun
    • , Han Sun
    • , Hidehito Kuroyanagi
    • , Dennis A. Webster
    • , Alexander W. Coutts
    • , Kimberly A. Holst
    • , Brooks S. Edwards
    • , Nikolas Newville
    • , Matthew A. Hathcock
    • , Tamene Melkamu
    • , Francesca Briganti
    • , Wu Wei
    • , Maria G. Romanelli
    • , Scott C. Fahrenkrug
    • , Doug E. Frantz
    • , Timothy M. Olson
    • , Lars M. Steinmetz
    • , Daniel F. Carlson
    • , Timothy J. Nelson
    • , Susana Cantero Peral
    • , Sarah Edgerton
    • , Joan Wobig
    • , Boyd Rasmussen
    • , Jodi A. Scholz
    • , Frank Cetta
    • , Scott H. Suddendorf
    • , Joanne M. Pedersen
    • , Steve Krage
    • , Craig S. Frisk
    • , Chelsea L. Reece
    • , Angela R. Miller
    • , Sara E. Martineau
    • , Rebecca K. Johnson
    • , Amanda L. Breuer
    •  & Janell K. Fox
  • Letter |

    Functionally competent memory CD8+ T cells specific for different viral epitopes are induced by SARS-CoV-2 infection and can be detected in the absence of virus-specific antibodies.

    • Isabel Schulien
    • , Janine Kemming
    • , Valerie Oberhardt
    • , Katharina Wild
    • , Lea M. Seidel
    • , Saskia Killmer
    • , Sagar
    • , Franziska Daul
    • , Marilyn Salvat Lago
    • , Annegrit Decker
    • , Hendrik Luxenburger
    • , Benedikt Binder
    • , Dominik Bettinger
    • , Oezlem Sogukpinar
    • , Siegbert Rieg
    • , Marcus Panning
    • , Daniela Huzly
    • , Martin Schwemmle
    • , Georg Kochs
    • , Cornelius F. Waller
    • , Alexandra Nieters
    • , Daniel Duerschmied
    • , Florian Emmerich
    • , Henrik E. Mei
    • , Axel Ronald Schulz
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    • , David A. Price
    • , Tobias Boettler
    • , Bertram Bengsch
    • , Robert Thimme
    • , Maike Hofmann
    •  & Christoph Neumann-Haefelin
  • Article |

    Polygenic risk scores are nearing a level of differentiation required for their clinical utility in risk prediction in populations with high-risk rare pathogenic genetic variants.

    • Robert W. Davies
    • , Ania M. Fiksinski
    • , Elemi J. Breetvelt
    • , Nigel M. Williams
    • , Stephen R. Hooper
    • , Thomas Monfeuga
    • , Anne S. Bassett
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    • , Donna M. McDonald-McGinn
    • , Ann Swillen
    • , Eva W. C. Chow
    • , Marianne van den Bree
    • , Beverly S. Emanuel
    • , Joris R. Vermeesch
    • , Therese van Amelsvoort
    • , Celso Arango
    • , Marco Armando
    • , Linda E. Campbell
    • , Joseph F. Cubells
    • , Stephan Eliez
    • , Sixto Garcia-Minaur
    • , Doron Gothelf
    • , Wendy R. Kates
    • , Kieran C. Murphy
    • , Clodagh M. Murphy
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    • , Nicole Philip
    • , Gabriela M. Repetto
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    • , Damiàn Heine Suñer
    • , Stefano Vicari
    • , Stephen W. Scherer
    • , Michael P. Epstein
    • , Stephen T. Warren
    • , Sinead Morrison
    • , Samuel Chawner
    • , Claudia Vingerhoets
    • , Jeroen Breckpot
    • , Elfi Vergaelen
    • , Annick Vogels
    • , Stephen Monks
    • , Sarah E. Prasad
    • , Corrado Sandini
    • , Maude Schneider
    • , Johanna Maeder
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    • , Rens Evers
    • , Flora Tassone
    • , Jaume Morey-Canyelles
    • , Opal Y. Ousley
    • , Kevin M. Antshel
    • , Wanda Fremont
    • , Rosemarie Fritsch
    • , Claudia Ornstein
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    • , Gregory A. Costain
    • , Erik Boot
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    • , Ehud Mekori-Domachevsky
    • , Elena Michaelovsky
    • , Ronnie Weinberger
    • , Carrie E. Bearden
    •  & Jacob A. S. Vorstman
  • Article |

    A universal method enables high-specificity, unbiased pathogen detection from diverse body fluids using metagenomic sequencing and may accelerate clinical decisions.

    • Wei Gu
    • , Xianding Deng
    • , Marco Lee
    • , Yasemin D. Sucu
    • , Shaun Arevalo
    • , Doug Stryke
    • , Scot Federman
    • , Allan Gopez
    • , Kevin Reyes
    • , Kelsey Zorn
    • , Hannah Sample
    • , Guixia Yu
    • , Gurpreet Ishpuniani
    • , Benjamin Briggs
    • , Eric D. Chow
    • , Amy Berger
    • , Michael R. Wilson
    • , Candace Wang
    • , Elaine Hsu
    • , Steve Miller
    • , Joseph L. DeRisi
    •  & Charles Y. Chiu

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COVID-19 and digital privacy

Marina Spence

COVID-19 and digital privacy

The COVID-19 pandemic has accelerated the development of digital public health and medical applications, and forced governments to use emergency powers to access health data.

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