Hepatitis B: a new weapon against an old enemy

A first-in-human study of an antisense oligonucleotide targeting hepatitis B virus RNA provides initial insights into this potential therapeutic modality for individuals with chronic HBV infection.


  • Structure of insulin.

    2021 marks the centenary of the discovery of insulin. This Milestone timeline highlights some of the key advances that have occurred in diabetes research over the past 100 years — from the development of synthetic insulin to new drug classes and technologies for the management of diabetes.

  • Preparing for the next pandemic

    Nature Medicine launches a special Focus dedicated to understanding the long-term impact of the COVID-19 pandemic, and to begin to explore the lessons that can be drawn from the mistakes in handling the current health crisis in order to prepare for future ones.

  • Crab, the avatar of cancer.

    The ancient physician Hippocrates described the projection of blood vessels from a collection of cells as ‘karkinos’, the Greek word for crab. Today, we know this malignant growth as cancer. These Milestones celebrate two decades of breakthroughs in basic, translational and clinical research which have revolutionised our understanding and management of cancer.

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  • The COVID-19 pandemic has exacerbated the already substantial burden of depression and anxiety, with tens of millions of additional cases reported globally in 2020.

    • Karen O’Leary
    Research Highlight
  • Under-reporting of fatal police violence is rife within the US government–run database — intervention strategies are urgently needed to quantify and address this public-health issue.

    • Karen O’Leary
    Research Highlight
  • A study shows that monozygotic (‘identical’) twins can be identified by a distinct epigenetic signature, shedding light on a process that has been shrouded in mystery.

    • Karen O’Leary
    Research Highlight
  • During the COVID-19 pandemic, the public have turned to scientists and doctors for vital information. But science communication is a skill in itself, so we asked the experts to share their tips.

    • Meenakshi J.
    News Feature
  • Protein structures predicted using artificial intelligence will aid medical research, but the greatest benefit will come if clinical data can be similarly used to better understand human disease.

    • Janet M. Thornton
    • Roman A. Laskowski
    • Neera Borkakoti

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