Raising the bar for clinical research

Latest Research

  • Letter |

    Antibodies in CSF specific for viral peptides implicate enteroviruses in acute flaccid myelitis.

    • Ryan D. Schubert
    • , Isobel A. Hawes
    • , Prashanth S. Ramachandran
    • , Akshaya Ramesh
    • , Emily D. Crawford
    • , John E. Pak
    • , Wesley Wu
    • , Carly K. Cheung
    • , Brian D. O’Donovan
    • , Cristina M. Tato
    • , Amy Lyden
    • , Michelle Tan
    • , Rene Sit
    • , Gavin A. Sowa
    • , Hannah A. Sample
    • , Kelsey C. Zorn
    • , Debarko Banerji
    • , Lillian M. Khan
    • , Riley Bove
    • , Stephen L. Hauser
    • , Amy A. Gelfand
    • , Bethany L. Johnson-Kerner
    • , Kendall Nash
    • , Kalpathy S. Krishnamoorthy
    • , Tanuja Chitnis
    • , Joy Z. Ding
    • , Hugh J. McMillan
    • , Charles Y. Chiu
    • , Benjamin Briggs
    • , Carol A. Glaser
    • , Cynthia Yen
    • , Victoria Chu
    • , Debra A. Wadford
    • , Samuel R. Dominguez
    • , Terry Fei Fan Ng
    • , Rachel L. Marine
    • , Adriana S. Lopez
    • , W. Allan Nix
    • , Ariane Soldatos
    • , Mark P. Gorman
    • , Leslie Benson
    • , Kevin Messacar
    • , Jennifer L. Konopka-Anstadt
    • , M. Steven Oberste
    • , Joseph L. DeRisi
    •  & Michael R. Wilson
  • Letter |

    Neurological phenotypes of PTEN loss are driven by aberrant mTORC2 signaling, and therapeutic inhibition of the mTORC2 component Rictor by antisense oligonucleotides reverses seizures, social interaction deficits and memory impairments in rodents.

    • Chien-Ju Chen
    • , Martina Sgritta
    • , Jacqunae Mays
    • , Hongyi Zhou
    • , Rocco Lucero
    • , Jin Park
    • , I-Ching Wang
    • , Jun Hyoung Park
    • , Benny Abraham Kaipparettu
    • , Loredana Stoica
    • , Paymaan Jafar-Nejad
    • , Frank Rigo
    • , Jeannie Chin
    • , Jeffrey L. Noebels
    •  & Mauro Costa-Mattioli
  • Letter |

    TRACERx Lung: Intratumoral transcriptional heterogeneity, which often hinders the development of clinically useful RNA-expression-biased biomarkers for cancer, can now be overcome with an approach for the identification of clonal expression biomarkers.

    • Dhruva Biswas
    • , Nicolai J. Birkbak
    • , Rachel Rosenthal
    • , Crispin T. Hiley
    • , Emilia L. Lim
    • , Krisztian Papp
    • , Stefan Boeing
    • , Marcin Krzystanek
    • , Dijana Djureinovic
    • , Linnea La Fleur
    • , Maria Greco
    • , Balázs Döme
    • , János Fillinger
    • , Hans Brunnström
    • , Yin Wu
    • , David A. Moore
    • , Marcin Skrzypski
    • , Christopher Abbosh
    • , Kevin Litchfield
    • , Maise Al Bakir
    • , Thomas B. K. Watkins
    • , Selvaraju Veeriah
    • , Gareth A. Wilson
    • , Mariam Jamal-Hanjani
    • , Judit Moldvay
    • , Johan Botling
    • , Arul M. Chinnaiyan
    • , Patrick Micke
    • , Allan Hackshaw
    • , Jiri Bartek
    • , Istvan Csabai
    • , Zoltan Szallasi
    • , Javier Herrero
    • , Nicholas McGranahan
    •  & Charles Swanton
  • Letter |

    Pulmonary venous tumor cells disseminating before tumor resection are heterogeneous, predict relapse and seed future metastasis of lung cancer

    • Francesca Chemi
    • , Dominic G. Rothwell
    • , Nicholas McGranahan
    • , Sakshi Gulati
    • , Chris Abbosh
    • , Simon P. Pearce
    • , Cong Zhou
    • , Gareth A. Wilson
    • , Mariam Jamal-Hanjani
    • , Nicolai Birkbak
    • , Jackie Pierce
    • , Chang Sik Kim
    • , Saba Ferdous
    • , Deborah J. Burt
    • , Daniel Slane-Tan
    • , Fabio Gomes
    • , David Moore
    • , Rajesh Shah
    • , Maise Al Bakir
    • , Crispin Hiley
    • , Selvaraju Veeriah
    • , Yvonne Summers
    • , Philip Crosbie
    • , Sophia Ward
    • , Barbara Mesquita
    • , Marek Dynowski
    • , Dhruva Biswas
    • , Jonathan Tugwood
    • , Fiona Blackhall
    • , Crispin Miller
    • , Allan Hackshaw
    • , Ged Brady
    • , Charles Swanton
    •  & Caroline Dive
  • Resource |

    Genetic variants in the germ line modulate DNA methylation in tumors and contribute to the aggressiveness of prostate cancer.

    • Kathleen E. Houlahan
    • , Yu-Jia Shiah
    • , Alexander Gusev
    • , Jiapei Yuan
    • , Musaddeque Ahmed
    • , Anamay Shetty
    • , Susmita G. Ramanand
    • , Cindy Q. Yao
    • , Connor Bell
    • , Edward O’Connor
    • , Vincent Huang
    • , Michael Fraser
    • , Lawrence E. Heisler
    • , Julie Livingstone
    • , Takafumi N. Yamaguchi
    • , Alexandre Rouette
    • , Adrien Foucal
    • , Shadrielle Melijah G. Espiritu
    • , Ankit Sinha
    • , Michelle Sam
    • , Lee Timms
    • , Jeremy Johns
    • , Ada Wong
    • , Alex Murison
    • , Michèle Orain
    • , Valérie Picard
    • , Hélène Hovington
    • , Alain Bergeron
    • , Louis Lacombe
    • , Mathieu Lupien
    • , Yves Fradet
    • , Bernard Têtu
    • , John D. McPherson
    • , Bogdan Pasaniuc
    • , Thomas Kislinger
    • , Melvin L. K. Chua
    • , Mark M. Pomerantz
    • , Theodorus van der Kwast
    • , Matthew L. Freedman
    • , Ram S. Mani
    • , Housheng H. He
    • , Robert G. Bristow
    •  & Paul C. Boutros
  • Article |

    A first-in-human, phase 1 dose-escalation trial demonstrates the safety and feasibility of autologous macrophage therapy in adults with liver cirrhosis.

    • Francesca Moroni
    • , Benjamin J. Dwyer
    • , Catriona Graham
    • , Chloe Pass
    • , Laura Bailey
    • , Lisa Ritchie
    • , Donna Mitchell
    • , Alison Glover
    • , Audrey Laurie
    • , Stuart Doig
    • , Emily Hargreaves
    • , Alasdair R. Fraser
    • , Marc L. Turner
    • , John D. M. Campbell
    • , Neil W. A. McGowan
    • , Jacqueline Barry
    • , Joanna K. Moore
    • , Peter C. Hayes
    • , Diana J. Leeming
    • , Mette J. Nielsen
    • , Kishwar Musa
    • , Jonathan A. Fallowfield
    •  & Stuart J. Forbes

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