Patient-partnered clinical research

Latest Research

  • Letter |

    Preliminary results from the Beat AML umbrella trial demonstrates the feasibility and efficacy of applying prospective genomic profiling for matching newly diagnosed patients with AML with targeted therapies.

    • Amy Burd
    • , Ross L. Levine
    • , Amy S. Ruppert
    • , Alice S. Mims
    • , Uma Borate
    • , Eytan M. Stein
    • , Prapti Patel
    • , Maria R. Baer
    • , Wendy Stock
    • , Michael Deininger
    • , William Blum
    • , Gary Schiller
    • , Rebecca Olin
    • , Mark Litzow
    • , James Foran
    • , Tara L. Lin
    • , Brian Ball
    • , Michael Boyiadzis
    • , Elie Traer
    • , Olatoyosi Odenike
    • , Martha Arellano
    • , Alison Walker
    • , Vu. H. Duong
    • , Tibor Kovacsovics
    • , Robert Collins
    • , Abigail B. Shoben
    • , Nyla A. Heerema
    • , Matthew C. Foster
    • , Jo-Anne Vergilio
    • , Tim Brennan
    • , Christine Vietz
    • , Eric Severson
    • , Molly Miller
    • , Leonard Rosenberg
    • , Sonja Marcus
    • , Ashley Yocum
    • , Timothy Chen
    • , Mona Stefanos
    • , Brian Druker
    •  & John C. Byrd
  • Article |

    Malaria cases are predominant during the rainy seasons in many endemic regions owing to the life cycle of the mosquito vector. How Plasmodium falciparum adapts in humans during the intervening dry season, without causing malaria symptoms or killing the host, offers new insights into its persistence in humans.

    • Carolina M. Andrade
    • , Hannah Fleckenstein
    • , Richard Thomson-Luque
    • , Safiatou Doumbo
    • , Nathalia F. Lima
    • , Carrie Anderson
    • , Julia Hibbert
    • , Christine S. Hopp
    • , Tuan M. Tran
    • , Shanping Li
    • , Moussa Niangaly
    • , Hamidou Cisse
    • , Didier Doumtabe
    • , Jeff Skinner
    • , Dan Sturdevant
    • , Stacy Ricklefs
    • , Kimmo Virtaneva
    • , Muhammad Asghar
    • , Manijeh Vafa Homann
    • , Louise Turner
    • , Joana Martins
    • , Erik L. Allman
    • , Marie-Esther N’Dri
    • , Volker Winkler
    • , Manuel Llinás
    • , Catherine Lavazec
    • , Craig Martens
    • , Anna Färnert
    • , Kassoum Kayentao
    • , Aissata Ongoiba
    • , Thomas Lavstsen
    • , Nuno S. Osório
    • , Thomas D. Otto
    • , Mario Recker
    • , Boubacar Traore
    • , Peter D. Crompton
    •  & Silvia Portugal
  • Article |

    A single-cell map of transcriptomic changes during acute liver failure unveils new insights into pathogenesis and potential therapeutic targets.

    • Aleksandra A. Kolodziejczyk
    • , Sara Federici
    • , Niv Zmora
    • , Gayatree Mohapatra
    • , Mally Dori-Bachash
    • , Shanni Hornstein
    • , Avner Leshem
    • , Debby Reuveni
    • , Ehud Zigmond
    • , Ana Tobar
    • , Tomer Meir Salame
    • , Alon Harmelin
    • , Amir Shlomai
    • , Hagit Shapiro
    • , Ido Amit
    •  & Eran Elinav
  • Article
    | Open Access

    A modeling study using case and mortality data from the first 8 months of the COVID-19 pandemic in the United States explores five potential future scenarios of social distancing mandates and mask use at the state level, with projections of the course of the epidemic through winter 2021.

    • Robert C. Reiner Jr
    • , Ryan M. Barber
    • , James K. Collins
    • , Peng Zheng
    • , Christopher Adolph
    • , James Albright
    • , Catherine M. Antony
    • , Aleksandr Y. Aravkin
    • , Steven D. Bachmeier
    • , Bree Bang-Jensen
    • , Marlena S. Bannick
    • , Sabina Bloom
    • , Austin Carter
    • , Emma Castro
    • , Kate Causey
    • , Suman Chakrabarti
    • , Fiona J. Charlson
    • , Rebecca M. Cogen
    • , Emily Combs
    • , Xiaochen Dai
    • , William James Dangel
    • , Lucas Earl
    • , Samuel B. Ewald
    • , Maha Ezalarab
    • , Alize J. Ferrari
    • , Abraham Flaxman
    • , Joseph Jon Frostad
    • , Nancy Fullman
    • , Emmanuela Gakidou
    • , John Gallagher
    • , Scott D. Glenn
    • , Erik A. Goosmann
    • , Jiawei He
    • , Nathaniel J. Henry
    • , Erin N. Hulland
    • , Benjamin Hurst
    • , Casey Johanns
    • , Parkes J. Kendrick
    • , Apurva Khemani
    • , Samantha Leigh Larson
    • , Alice Lazzar-Atwood
    • , Kate E. LeGrand
    • , Haley Lescinsky
    • , Akiaja Lindstrom
    • , Emily Linebarger
    • , Rafael Lozano
    • , Rui Ma
    • , Johan Månsson
    • , Beatrice Magistro
    • , Ana M. Mantilla Herrera
    • , Laurie B. Marczak
    • , Molly K. Miller-Petrie
    • , Ali H. Mokdad
    • , Julia Deryn Morgan
    • , Paulami Naik
    • , Christopher M. Odell
    • , James K. O’Halloran
    • , Aaron E. Osgood-Zimmerman
    • , Samuel M. Ostroff
    • , Maja Pasovic
    • , Louise Penberthy
    • , Geoffrey Phipps
    • , David M. Pigott
    • , Ian Pollock
    • , Rebecca E. Ramshaw
    • , Sofia Boston Redford
    • , Grace Reinke
    • , Sam Rolfe
    • , Damian Francesco Santomauro
    • , John R. Shackleton
    • , David H. Shaw
    • , Brittney S. Sheena
    • , Aleksei Sholokhov
    • , Reed J. D. Sorensen
    • , Gianna Sparks
    • , Emma Elizabeth Spurlock
    • , Michelle L. Subart
    • , Ruri Syailendrawati
    • , Anna E. Torre
    • , Christopher E. Troeger
    • , Theo Vos
    • , Alexandrea Watson
    • , Stefanie Watson
    • , Kirsten E. Wiens
    • , Lauren Woyczynski
    • , Liming Xu
    • , Jize Zhang
    • , Simon I. Hay
    • , Stephen S. Lim
    •  & Christopher J. L. Murray
  • Brief Communication |

    Survey data from across 19 countries reveal heterogeneity in attitudes toward acceptance of a COVID-19 vaccine and suggest that trust in government is associated with vaccine confidence.

    • Jeffrey V. Lazarus
    • , Scott C. Ratzan
    • , Adam Palayew
    • , Lawrence O. Gostin
    • , Heidi J. Larson
    • , Kenneth Rabin
    • , Spencer Kimball
    •  & Ayman El-Mohandes
  • Article |

    The largest whole-exome sequencing study of sporadic congenital hydrocephalus identities mutations associated with disrupted fetal neuro-gliogenesis as the primary pathophysiological event in a significant number of cases.

    • Sheng Chih Jin
    • , Weilai Dong
    • , Adam J. Kundishora
    • , Shreyas Panchagnula
    • , Andres Moreno-De-Luca
    • , Charuta G. Furey
    • , August A. Allocco
    • , Rebecca L. Walker
    • , Carol Nelson-Williams
    • , Hannah Smith
    • , Ashley Dunbar
    • , Sierra Conine
    • , Qiongshi Lu
    • , Xue Zeng
    • , Michael C. Sierant
    • , James R. Knight
    • , William Sullivan
    • , Phan Q. Duy
    • , Tyrone DeSpenza
    • , Benjamin C. Reeves
    • , Jason K. Karimy
    • , Arnaud Marlier
    • , Christopher Castaldi
    • , Irina R. Tikhonova
    • , Boyang Li
    • , Helena Perez Peña
    • , James R. Broach
    • , Edith M. Kabachelor
    • , Peter Ssenyonga
    • , Christine Hehnly
    • , Li Ge
    • , Boris Keren
    • , Andrew T. Timberlake
    • , June Goto
    • , Francesco T. Mangano
    • , James M. Johnston
    • , William E. Butler
    • , Benjamin C. Warf
    • , Edward R. Smith
    • , Steven J. Schiff
    • , David D. Limbrick Jr
    • , Gregory Heuer
    • , Eric M. Jackson
    • , Bermans J. Iskandar
    • , Shrikant Mane
    • , Shozeb Haider
    • , Bulent Guclu
    • , Yasar Bayri
    • , Yener Sahin
    • , Charles C. Duncan
    • , Michael L. J. Apuzzo
    • , Michael L. DiLuna
    • , Ellen J. Hoffman
    • , Nenad Sestan
    • , Laura R. Ment
    • , Seth L. Alper
    • , Kaya Bilguvar
    • , Daniel H. Geschwind
    • , Murat Günel
    • , Richard P. Lifton
    •  & Kristopher T. Kahle

News & Comment

  • Comment |

    The limitations of using race in biomedicine are important to recognize because race is often afforded more biological value than can be scientifically justified — and less social value than it commands.

    • George Adigbli
  • Turning Points |

    Kizzmekia ‘Kizzy’ Corbett, a viral immunologist and research fellow, is the team lead for coronavirus research within the Viral Pathogenesis Laboratory of the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases, part of the US National Institutes of Health.

    • Kizzmekia Corbett
  • News & Views |

    The Zero Childhood Cancer Program’s multi-platform sequencing approach identified molecular alterations in 94% of a cohort of 247 pediatric patients with high-risk cancers, which has enabled more-precise diagnoses and alternative therapeutic recommendations.

    • Djihad Hadjadj
    • , Shriya Deshmukh
    •  & Nada Jabado

Focus

COVID-19 and digital privacy

Marina Spence

COVID-19 and digital privacy

The COVID-19 pandemic has accelerated the development of digital public health and medical applications, and forced governments to use emergency powers to access health data.

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