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Volume 4 Issue 12, December 2003

Zebrafish are an exciting model organism because of their readily manipulated genetics and transparent nature. Zon and colleagues report on pp. 1238–1246 that immune system development could be amenable to study in zebrafish. This 2-day-old embryo illustrates how one can monitor multilineage hematopoiesis in living zebrafish after transplantation of transgenic donor marrow carrying red (leukocytes; gata1dsRED) and green (erythrocytes; bactineGFP) fluorescent markers. Digital image by D. Travers.

Volume 4 Issue 12

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  • The Toll-like receptor (TLR) family targets pathogen-derived molecules in regions unlikely to change under selection pressures. For TLR5, which recognizes the protein flagellin, the function of the targeting motif is key.

    • Jean-Marc Reichhart
    News & Views

  • Mast cells are not only important in IgE-associated disorders but also contribute to host defense against bacteria. One way they do this is by enhancing T cell recruitment and lymph node enlargement during bacterial infection.

    • Stephen J Galli
    • Susumu Nakae
    News & Views

  • TLR ligands mediate adjuvant effects. Unlike lipopolysaccharide, poly(I:C) is capable of using a TLR-Trif–independent pathway to induce costimulatory molecule upregulation on antigen-presenting cells.

    • Egil Lien
    • Douglas T Golenbock
    News & Views

  • Although natural killer T cells are activated during infection, it is not clear how this process occurs. Closer examination indicates that recognition of endogenous ligands and interleukin 12, rather than bacterial products, may drive the activation process.

    • Masaru Taniguchi
    • Ken-ichiro Seino
    • Toshinori Nakayama
    News & Views
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