Volume 19 Issue 6, June 2018

Volume 19 Issue 6

AhR-driven IL-10 production

McGaha and colleagues show that phagocytosis of apoptotic cells leads to activation of AhR and production of IL-10 in phagocytes, in a manner dependent on DNA recognition.

See Shinde et al.

Image: Rahul Shinde and Battista Clavier. Cover Design: Erin Dewalt.

Obituary

Research Highlights

News & Views

  • News & Views |

    The metabolic master regulator mTORC1 is shown to promote alternative macrophage activation via Semaphorin 6D reverse signaling and reprogramming of lipid metabolism.

    • Jayne Louise Wilson
    •  & Thomas Weichhart
  • News & Views |

    Human affinity-matured antibodies to Klebsiella pneumoniae lipopolysaccharide O-antigen have different patterns of glycan fine specificity without being polyreactive. These antibodies might constitute an important mechanism for homeostatic control of the intestinal microbiome.

    • Jiwon Lee
    •  & George Georgiou
  • News & Views |

    Naive T cells migrate rapidly through the lymph node. A high-resolution look at the chemokine receptor CCR7 and integrin LFA-1 reveals that T cells remain highly responsive to their microenvironment via instantaneous tuning of chemokine-regulated actin flow and integrin-regulated adhesion.

    • Patrick W. Oakes
    •  & Deborah J. Fowell
  • News & Views |

    Analysis of whole-blood transcriptional profiles in adults hospitalized with influenza reveals time- and severity-related gene-expression signatures.

    • David F. Tough

Meeting Reports

  • Meeting Report |

    Tuberculous meningitis is a serious, life-threatening disease affecting vulnerable populations, including HIV-infected individuals and young children. The US National Institutes of Health convened a workshop to identify knowledge gaps in the molecular and immunopathogenic mechanisms of tuberculous meningitis and to develop a roadmap for basic and translational research that could guide clinical studies.

    • Sanjay K. Jain
    • , David M. Tobin
    • , Elizabeth W. Tucker
    • , Vishwanath Venketaraman
    • , Alvaro A. Ordonez
    • , Lakshmi Jayashankar
    • , Omar K. Siddiqi
    • , Dima A. Hammoud
    • , Nemani V. Prasadarao
    • , Matyas Sandor
    • , Richard Hafner
    •  & Zsuzsanna Fabry

Review Articles

Articles

  • Article |

    CARD9 serves as an adaptor for C-type lectin receptor signaling. Xin Lin and colleagues show that CARD9 inhibits RelB-mediated IL-5 expression. The CARD9S12N mutant, prevalent in humans, cannot interact with RelB and promotes enhanced allergic responses to fungal pathogens.

    • Xia Xu
    • , Jin-Fu Xu
    • , Guoxing Zheng
    • , Hai-Wen Lu
    • , Jie-Lin Duan
    • , Wei Rui
    • , Jian-Hong Guan
    • , Li-Qing Cheng
    • , Dan-Dan Yang
    • , Ming-Chao Wang
    • , Quan-Zhen Lv
    • , Jian-Xiong Li
    • , Xueqiang Zhao
    • , Chun-Xia Chen
    • , Peng Shi
    • , Xin-Ming Jia
    •  & Xin Lin
  • Article |

    Semaphorins play well-known roles in axon guidance. Kumanogoh and colleagues demonstrate that Semaphorin 6D cell-intrinsically activates anti-inflammatory macrophage polarization.

    • Sujin Kang
    • , Yoshimitsu Nakanishi
    • , Yoshiyuki Kioi
    • , Daisuke Okuzaki
    • , Tetsuya Kimura
    • , Hyota Takamatsu
    • , Shohei Koyama
    • , Satoshi Nojima
    • , Masayuki Nishide
    • , Yoshitomo Hayama
    • , Yuhei Kinehara
    • , Yasuhiro Kato
    • , Takeshi Nakatani
    • , Tomomi Shimogori
    • , Junichi Takagi
    • , Toshihiko Toyofuku
    •  & Atsushi Kumanogoh
  • Article |

    McGaha and colleagues show that phagocytosis of apoptotic cells leads to activation of the transcription factor AhR and production of the cytokine IL-10 in phagocytes, in a manner dependent on the recognition of DNA.

    • Rahul Shinde
    • , Kebria Hezaveh
    • , Marie Jo Halaby
    • , Andreas Kloetgen
    • , Ankur Chakravarthy
    • , Tiago da Silva Medina
    • , Reema Deol
    • , Kieran P. Manion
    • , Yuriy Baglaenko
    • , Maria Eldh
    • , Sara Lamorte
    • , Drew Wallace
    • , Sathi Babu Chodisetti
    • , Buvana Ravishankar
    • , Haiyun Liu
    • , Kapil Chaudhary
    • , David H. Munn
    • , Aristotelis Tsirigos
    • , Michael Madaio
    • , Susanne Gabrielsson
    • , Zahi Touma
    • , Joan Wither
    • , Daniel D. De Carvalho
    •  & Tracy L. McGaha
  • Article |

    Dyslipidemia and autoimmune disease are often associated. Chung and colleagues demonstrate a mechanistic pathway by which dyslipidemia leads to the induction of pathogenic autoantibodies.

    • Heeju Ryu
    • , Hoyong Lim
    • , Garam Choi
    • , Young-Jun Park
    • , Minkyoung Cho
    • , Hyeongjin Na
    • , Chul Won Ahn
    • , Young Chul Kim
    • , Wan-Uk Kim
    • , Sang-Hak Lee
    •  & Yeonseok Chung
  • Article |

    Sixt, Stein and colleagues show that during T cell migration within lymphatic organs, the chemokine receptor CCR7 quantitatively controls the speed of a continuous actin flow, which is coupled to the environment by the integrin LFA-1.

    • Miroslav Hons
    • , Aglaja Kopf
    • , Robert Hauschild
    • , Alexander Leithner
    • , Florian Gaertner
    • , Jun Abe
    • , Jörg Renkawitz
    • , Jens V. Stein
    •  & Michael Sixt
  • Article |

    Carbohydrate-specific antibodies are typically thought to be of low affinity and produced by T cell–independent pathways. Wardemann and colleagues identify human memory B cells that can produce specific ‘affinity-matured’ antibodies to the O antigen of Klebsiella lipopolysaccharides.

    • Tim Rollenske
    • , Valeria Szijarto
    • , Jolanta Lukasiewicz
    • , Luis M. Guachalla
    • , Katarina Stojkovic
    • , Katharina Hartl
    • , Lukas Stulik
    • , Simone Kocher
    • , Felix Lasitschka
    • , Mohammed Al-Saeedi
    • , Jutta Schröder-Braunstein
    • , Moritz von Frankenberg
    • , Gereon Gaebelein
    • , Peter Hoffmann
    • , Sabrina Klein
    • , Klaus Heeg
    • , Eszter Nagy
    • , Gabor Nagy
    •  & Hedda Wardemann

Resources

  • Resource |

    Influenza can occasionally result in life-threatening sequelae. Openshaw and colleagues describe the functional and transcriptional response to natural infection with influenza virus and find that a transition to an ‘anti-bacterial response’ is associated with more-severe symptoms.

    • Jake Dunning
    • , Simon Blankley
    • , Long T. Hoang
    • , Mike Cox
    • , Christine M. Graham
    • , Philip L. James
    • , Chloe I. Bloom
    • , Damien Chaussabel
    • , Jacques Banchereau
    • , Stephen J. Brett
    • , Maximillian S. Habibi
    • , Sebastian L. Johnston
    • , Trevor T. Hansel
    • , Mike Levin
    • , Ryan S. Thwaites
    • , John O. Warner
    • , William O. Cookson
    • , Brian G. Gazzard
    • , Alan Hay
    • , John McCauley
    • , Paul Aylin
    • , Deborah Ashby
    • , Wendy S. Barclay
    • , Ruth A. Elderfield
    • , Simon Nadel
    • , Jethro A. Herberg
    • , Lydia N. Drumright
    • , Laura Garcia-Alvarez
    • , Alison H. Holmes
    • , Onn M. Kon
    • , Stephen J. Aston
    • , Stephen B. Gordon
    • , Tracy Hussell
    • , Catherine Thompson
    • , Maria C. Zambon
    • , Kenneth J. Baillie
    • , David A. Hume
    • , Peter Simmonds
    • , Andrew Hayward
    • , Rosalind L. Smyth
    • , Paul S. McNamara
    • , Malcolm G. Semple
    • , Jonathan S. Nguyen-Van-Tam
    • , Ling-Pei Ho
    • , Andrew J. McMichael
    • , Paul Kellam
    • , Walt E Adamson
    • , William F Carman
    • , Mark J. Griffiths
    • , Miriam F. Moffatt
    • , Anne O’Garra
    •  & Peter J. M. Openshaw

Technical Reports

  • Technical Report |

    Isolating tissue-resident cells runs the risk of altering their expression profile. Jung and colleagues use a RiboTagging approach to describe the microglial translatome and demonstrate that macrophage extraction from their tissue environment results in significant transcriptional alterations.

    • Zhana Haimon
    • , Alon Volaski
    • , Johannes Orthgiess
    • , Sigalit Boura-Halfon
    • , Diana Varol
    • , Anat Shemer
    • , Simon Yona
    • , Binyamin Zuckerman
    • , Eyal David
    • , Louise Chappell-Maor
    • , Ingo Bechmann
    • , Martin Gericke
    • , Igor Ulitsky
    •  & Steffen Jung

Amendments & Corrections