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Twenty-five years after its identification, the transcription factor NF-κB continues to attract intense effort from a large and diverse research community. Ranjan Sen offers a personal account of the discovery of NF-κB.
Jim Gowans opened a new era of immunology by combining physiological in vivo studies with prospective enrichment of small lymphocytes, validating the clonal selection theory, discovering lymphocyte homing and recirculation, and training others to follow.
October 2007 marks the 50th anniversary of the publication of Frank Macfarlane Burnet's clonal selection theory in the Australian Journal of Science. This short article, republished at the end of this commentary, revolutionized the field of immunology.
In honor of the fiftieth anniversary of Frank MacFarlane Burnet's presentation of the clonal selection theory, two of his former staff reminisce about their interactions with this Nobel prize–winning scientist.