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Treg cells control effector cells such as TH1 and TFH cells. Chi and colleagues demonstrate that PTEN is cell-intrinsically required for Treg cell lineage stability and regulation of effector T cell responses.
Regulatory T cells normally maintain high expression of the phosphatase PTEN. Turka and colleagues use conditional deletion of PTEN in regulatory T cells to show that it is critical for their function and stability.