News & Views in 2014

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  • The viability of long-lived plasma cells is enhanced by the expression of inducible nitric oxide synthase, which relieves endoplasmic reticulum stress by triggering a response dependent on cGMP and protein kinase G.

    • Modesta N Njau
    • Joshy Jacob
    News & Views
  • In addition to its canonical role in reverse cholesterol transport, high-density lipoprotein can suppress inflammation in target cells through the induction of Atf3, which encodes a well-known transcriptional repressor.

    • Justin I Odegaard
    • Ajay Chawla
    News & Views
  • Acute inhibition of the regulatory kinase Csk reveals additional checkpoints for full activation of thymocytes via the T cell antigen receptor.

    • Michael L Dustin
    • Simon J Davis
    News & Views