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The viability of long-lived plasma cells is enhanced by the expression of inducible nitric oxide synthase, which relieves endoplasmic reticulum stress by triggering a response dependent on cGMP and protein kinase G.
In addition to its canonical role in reverse cholesterol transport, high-density lipoprotein can suppress inflammation in target cells through the induction of Atf3, which encodes a well-known transcriptional repressor.
Gene-expression signatures of the human vaccine response can be complex and noisy. Li et al. develop a new collection of gene-expression modules and use it to compare the response to five different vaccines.