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Here, the authors show that a subset of NKT2 cells are programmed during thymic development at early postnatal ages to migrate to the skin, where they support local tissue homeostasis through regulation of iron metabolism.
Trained immunity can manifest as a form of innate immune memory whereby innate immune cell responses are reprogrammed to respond differently to a variety of stimuli. Here, the authors show that lung macrophages can be trained by whole beta-glucan particle to enhance their ability to control tumor metastasis.
Gasdermin E pore formation has been associated with pyroptotic cell death. Here the authors identify gasdermin E pores in a subset of human TH17 cells and show that rather than killing these cells the pores enable the release of IL-1α on NLRP3 inflammasome activation as an antifungal immune response.