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CAR T cells put the brakes on asthma
CAR T cell technology is being extended beyond the treatment of cancer. New data show that it might also treat allergic asthma, with a single infusion sufficient to prevent pathology for over a year in mice.
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Functions of natural killer cells
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A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice
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Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R–STAT5B-driven neoplasms
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Leveraging dirty mice that have microbial exposure to improve preclinical models of human immune status and disease