Volume 9 Issue 4, April 2006
News & Views
Even chromatin gets the blues
Antidepressants take a few weeks to act, and their effects can extend for months after the drugs are discontinued. Tsankova et al. suggest a possible molecular basis for these effects, by showing that stress and the antidepressant imipramine induce modifications of chromatin to produce more or less repressive states for gene expression.
A mint of mutations in TRPM8 leads to cool results
Both menthol and cool temperatures activate the cation channel TRPM8, but whether they do so via distinct domains was unclear. A new paper shows that activation of TRPM8 by these two stimuli can be separated.
Measuring the brain's assumptions
A Bayesian model of visual motion perception describes how the brain combines assumptions with evidence. A new study in this issue tests and expands the model, building connections between perception, the environment and neural responses.
Go with the flow: signaling from the ventricle directs neuroblast migration
Neurons born in the adult subventricular zone migrate a long way to their destination. A new study suggests that signals from the corticospinal fluid, in particular the chemorepellent Slit2, guide adult neuroblast migration.
Traditional learning theory suggests that animals do not understand that actions cause their consequences. A new paper uses sophisticated behavioral experiments to conclude that rats are capable of causal reasoning.